Androstane therapy of aplastic anaemia.
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Biomedical subjects
Publications and source records attributed to R López Sandoval.
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A 65 years old, female patient with acquired aplastic anemia secondary to frequent exposure to hair dye. While on treatment with anabolic steroids hormone became jaundiced and developed hepatomegaly eight months later. During laparotomy the liver was enlarged, hard, with multiple whitish nodules on its surgace but was otherwise normal. Liver biopsy showed hepatocellular carcinoma, there were not cirrhosis niether hemochromatosis. A review of the related literature was done and discussed on the experimental and clinical evidences that suggested that androgens may play same role on the etiology of liver cancer.
A 35 years old female with peliosis hepatis is reported. She came to us complaining of muscular aches. The only positive finding at the physical examination was a normal size liver but palpable in a deep breath; it was hard, no tender, with smooth surface. The laboratory work up was negative except for a mild increase in transaminase values. The liver biopsy disclosed the characteristic lacunar spaces fulfilled with blood. This is an unusual case because it was not associated with any other former or present disease. A review of the pertinent literature was made.
In this paper the authors present the clinical case of a nine years old girl with adenopathy, fever and important weight loss. 10 months after she begins with diphenidantoin the differential diagnosis was attempted between lymphoma and drug reaction. The authors reviewed the literature pointed out the development of lymphomas in patients on diphenidantoin therapy. They mention the different hipothesis to explain this drug-lymphoma interrelation concluding that there is necessary more studies and experience in future cases to clarify the certain role of the anticonvulsivants in the production of this abnormalities.