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R LaBrie

Publications and source records attributed to R LaBrie.

4 recordsLinked to original sources
PubMed1999

Measuring interstate variations in drug problems.

This article describes the Drug Problem Index (DPI), a composite index measuring the interstate severity of drug abuse problems. The DPI's components (drug-coded mortality, drug-defined arrest, and drug-treatment client rates) were selected because they were linked closely with drug abuse, data were available for all states, and there was published evidence of their validity. The variables were reliable, and their convergent validity was estimated in a multi-trait, multi-method matrix. We found evidence consistent with the DPI's construct validity in its relations with other consequences of drug abuse. The DPI correlated significantly with the Block Grant drug need index but not with model estimates of drug dependence based on the National Household Survey.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Effect of beta blockade on plasma catecholamine levels during psychological and exercise stress.

The effect of a single oral dose of 50 mg of metoprolol on plasma catecholamine levels was examined in 11 healthy young men. Subjects were studied during baseline at rest, postural challenge, psychological stressors and graded maximal exercise testing. Metoprolol induced significant increases in plasma norepinephrine (NE) levels across most experimental conditions. Metoprolol did not have a consistent effect on plasma epinephrine levels. Because of wide interindividual variation in drug levels, the NE levels in subjects with high drug levels were compared with the NE levels in subjects who had negligible drug levels. NE levels were higher in subjects with higher drug levels.

Adult↗
PubMed1978

Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results.

In order to assess the subjective effects of nefopam, a new non-opiate analgesic, a study was designed using highly educated, young, middle-to-upper class subjects in a naturalistic setting. Results suggest that the design is capable of differentiating variations in subjective drug effects. On a number of measures, 10 mg of d-amphetamine, a modest dosage, could be distinguished from placebo, showing changes in the direction expected for stimulant drugs. Nefopam (90 mg), on the other hand, showed few differences from placebo or caffeine (300 mg). Nefopam appeared mildly dysphoric, rather than stimulant, in subjective effects.

Adult↗