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Biomedical subjects

R Lacroix

Publications and source records attributed to R Lacroix.

At least 19 recordsLinked to original sources
PubMed1992

Pain-elicited responses and their role in predicting future pain duration and severity.

The first objective of this study was to carry out a prospective investigation of the behavioral and affective responses to headache pain over a 72 hr period. A sample of 74 headache sufferers provided self-reported ratings of affective and behavioral responses as measured by a composite of standardized questionnaires. Highly significant and clinically meaningful levels of both types of responses were found on the headache day. Interestingly, significant levels of behavioral and affective disturbances were also reported 24 hr after pain termination, indicating that responses to pain actually outlasted pain perception by at least 1 day. The second goal of this study was to investigate whether affective or behavioral responses were predictors of future pain intensity, duration or severity. A smaller sample of 25 subjects provided ratings on two sequential headaches. A series of time-lag analyses indicated that, unlike behavioral responses, strong affective responses during a given episode were associated with subsequently longer and more severe headaches. These results suggest that affective pain-elicited responses may be a risk factor for suffering a worse headache during the episode that follows.

Adaptation, Psychological↗
PubMed1992

Multiple phantom limbs in a child.

This case report describes multiple phantom feet in a child after amputation of a leg. The subject is a 16-year-old girl who was born with a right leg 10 cm shorter than the left and who at the age of 6 was amputated below the right knee so that she could wear a prosthesis that would give her normal mobility. The girl reports that she subsequently experienced 2 phantom feet and 3 sets of phantom toes which have persisted to the present time. Each phantom has a distinct size, length and position in relation to the others and each is also the site of vivid sensations such as heat, tickle, and fatigue as well as voluntary and involuntary movement. She also describes sensations that resemble sensations experienced before the amputation: one of her phantom feet feels flat and locked into a forward position which corresponds with the actual shape and position of her congenitally deformed amputated foot. The implications of multiple phantoms are discussed with reference to recent concepts of phantom limbs.

Adolescent↗
PubMed1992

[Structural typology assay of principal anticancer agents on the basis of molecular fragmentation].

The developed formula of 58 anticancer agents used in therapeutic or still in clinical essays were treated by molecular connectivity matrix method. This technic allows the search and the automatically count of structural fragments of the different studied molecules. Then it has been possible to build a spanning tree (Prim's arborescent skeleton) which gathers the different molecules and permits to put a priori new structures.

Antineoplastic Agents↗
PubMed1992

[Overall analysis of structural factors responsible for the activity and toxicity of antiparasitic agents used in therapy].

A mini-data bank was constituted from the 73 french antiparasitic patent medicines and was implanted in microcomputer. A maximum of chemical, pharmaceutical, therapeutical and toxicological data were collected and treated by multivariate analysis. Exploitation of these informations processing allows to take out correlations between chemical structure toxicity, and specificity.

Anthelmintics↗
PubMed1991

Labor pain: effect of maternal position on front and back pain.

The purpose of this study was to determine whether women in labor report less pain when they are in a vertical (sitting or standing) position than in a horizontal (side-lying or supine) position. Pain scores were obtained from 60 women in early labor (dilation 2-5 cm) who alternated between the two positions. The results show that about 35% of women feel less front pain and 50% feel less back pain when they are in a vertical position than in a horizontal position. The decrease in continuous back pain (83%) was particularly impressive, but the front and back pains associated with contractions were significantly diminished as well. These results, taken together with those of earlier studies, indicate that many women in early labor have less pain and are generally more comfortable in a vertical than in a horizontal position. Since early labor comprises a substantial proportion of the entire process of labor and delivery, any simple procedure which alleviates pain without danger to mother or child, such as shifting from a horizontal to a vertical position, should be promoted and employed.

Adolescent↗
PubMed1990

The impact of recurrent headaches on behavior lifestyle and health.

The goal of this study was to examine whether behavioral avoidance was pervasive in a sample of headache sufferers as has been suggested by Philips (Behavior Research and Therapy, 25, 273-279, 1987). One hundred and fifty participants provided retrospective evaluations of behavior changes perceived to have resulted from repeated exposure to headache pain. The outcome of these self-assessments underscored marked changes in several domains of behavior and overall lifestyle. This evidence therefore provided support for Philips' position since the changes appeared persistent, even during pain-free states.

Adaptation, Psychological↗
PubMed1989

[Multiparameter analysis approach of antiparasitic structure-activity relationships in function of the parasite taxonomy].

In this paper the authors have studied the structure-parasitic activity relationships through the Chemical Abstracts data base which groups together the works published in this field for the last twenty years. With mathematical methods of multidimensional data reduction using a computer it has been possible to validate the classification of human parasites on the base of their sensitivity to chemical families. The specificity of the pharmacochemical relationships was described through two factorial maps. This work shows that it is possible to find new chemical series with potential parasitic activity.

Animals↗
PubMed1979

Electroretinographic study during acute Aramite intoxication of the white mouse.

Aramite was injected to white mice and the electroretinograms recorded in response to electronic flashes. The following phenomena were remarked: a more and more important flattening of a-waves; a simultaneous collapse of b-waves; a more and more delayed return of a-waves to the isoelectric line; vanishing c-waves. Those actions were explained by an intoxication of the photoreceptors by Aramite and by a resulting difficulty of the photoreceptors to stimulate bipolar cells.

Alkanesulfonates↗
PubMed1978

[Action of carbaryl on the electroretinogram of the white mouse].

Carbaryl intoxication results in important modifications of the Mouse ERG, with an increase of the latency and a decrease of the amplitude, then a suppression of b-wave. This action is supposed to be provoked by the anticholinesterasic properties of carbamates, which result in a section of retinian synapses.

Animals↗
PubMedDate not supplied

[The manipulation of information of developed formulas for the study of structure-activity relationships. Application to antiparasitic agents].

Beside traditional univariate methods of pharmacochemical (pharmacomodulation...), and of molecular pharmacology ("binding"...) most global approach (multivariate) of structure-activity and structure-toxicity relationships may been in action with processing implement. Developed formula may been treated by different algorithmic methods as molecular connectivity matrix which use atoms, bindings, chemical functions, fragments, of any molecule. This technique allows to research and to automatically count structural fragments of molecule, different in their chemical aspect but having the same port of activity. So, with this profile of fragments it is possible to build a spanning tree (PRIM'S arborescent skeleton) and to place a priori on it, new structures with other properties to value their activity level in the designed field. We applied these techniques to 50 most prescribed antiparasitic active principles.

Information Systems↗