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Biomedical subjects

R Lagier

Publications and source records attributed to R Lagier.

153 records · Page 9Linked to original sources
PubMedDate not supplied

Erosive intervertebral osteochondrosis in association with generalized osteoarthritis and chondroc alcinosis; anatomico-radiological study of a case.

This paper concerns a radiological and postmortem study of an 81-year-old woman with diffuse intervertebral osteochondrosis (T12-L1 severe erosion) in association with generalized osteoarthritis and articular chondrocalcinosis. Varying degrees of cartilage plate flaws with cartilaginous Schmorl's nodes and vertebral plateaux erosion are shown to occur without calcium pyrophosphate crystal deposits in situ. Differential diagnosis between intervertebral osteochondrosis and infectious spondylitis may require a combination of tomographic evolution over time, bone scans and biopsy, the latter being not always conclusive.

Aged↗
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[Extraspinal erosions of tendon insertions in ankylosing spondylitis].

A study based on the clinical observation of 9 adults carrying the HLA B27 antigen. Seven of these patients had a typical ankylosing spondylitis with bilateral sacro-iliitis. The other two cases were considered to have a minor form of the disease, without sacro-iliitis. In various zones of tendinous or ligamentous insertion (on the calcaneal and ischial tuberosities, the anterior tibial tuberosity, the patella, the lateral femoral condyle, the metataŕso-phalangeal epiphyses of the index finger, the head of the humerus), the patients complained of pain and presented radiological images of more or less developed bony erosion. These erosion of insertions are not specific to ankylosing spondylitis, but they can be suggestive of the diagnosis. They can be an important element in the diagnosis of pre-spondylitic forms, especially in adolescents. Certain histological findings suggest that these lesions are a form of localized algodystrophy.

Adult↗
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Is a certain degree of osteomalacia involved in femoral neck fractures of the elderly? Histological approach to the problem and practical applications.

A study was made in Geneva of 14 patients with femoral neck fractures (7 subcapital and 7 trochanteric) to determine whether a certain degree of osteomalacia might be involved (group I). No patients with risks factors for osteomalacia were used. For ethical reasons, double tetracycline labelling was not possible and osteomalacia criteria were based on osteoid tissue values determined in a histomorphometric study directly on cancellous bone samples of the femoral head. A comparison was made with femoral head bone tissue taken from 12 patients with hip osteoarthritis at a distance from the remodelled territory (group II) and with iliac crest bone tissue taken from 6 patients with clinically and biochemically determined osteomalacia (group III). The patients were part of a larger group of subjects used for a biochemical blood study in which levels of albumin, calcium and 25 OHD3 as an index of vitamin D content were determined. Based on the data of the literature and the results obtained for group II, slight signs of osteomalacia were diagnosed for only one case (group I), although 25 OHD3 deficiency was found in more than a third of the subjects in that group as well as in some subjects of group II and in some of the aged controls. Skeletal aging must be considered not only in terms of unavoidable physiological factors but also within the context of living conditions. Hence the necessity of controlling calcium and vitamin D intake in the elderly, and of a histological examination for signs of osteomalacia in surgical specimens from patients with femoral neck fractures.

Aged↗
PubMedDate not supplied

Achilles tendinitis associated with chondrocalcinosis.

Achilles tendinitis was observed in 3 patients with idiopathic articular chondrocalcinosis. It was associated with linear radiological calcifications which in this condition are not unusual but generally asymptomatic. Crystals presumed to be calcium pyrophosphate dihydrate (CPPD) were found in the 2 cases that were biopsied. In 2 patients the acute inflammation of the tendon subsided after several days, but in the 3rd it lasted 4 1/2 months, and resulted in a cicatricial thickening of the tendon with a progressive disappearence of the calcifications. Therefore, the development of Achilles tendinitis in an elderly patient may be an inflammatory reaction to CPPD crystal deposits.

Achilles Tendon↗