[Cerebral glioblastoma with cerebellar metastasis. Report of 3 cases].
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Biomedical subjects
Publications and source records attributed to R Lahl.
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A report is given on pathomorphic local findings in the cervical vessels and cerebral complications after direct (percutaneous) carotid angiography (d.c.a.). The studies were based on 1345 d.c.a. in 1199 patients of our establishment carried out in the period from July 1966 to the end of 1981. 112 d.c.a. of 102 decreased and dissected patients were pathomorphically evaluated. Of these, 12 cases showed massive angiographically produced findings in the cervical vessels, five of them with verified cerebral complications. In the cervical vessels, both A. carotis communis and V. jugularis may be affected. Circulatory disturbances of the cerebrum manifest themselves in anaemic and/or haemorrhagic disturbances. The relative importance of complications after d.c.a., their frequency as well as possibilities of a reduction are discussed.
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In post-mortem material with pronounced primary epilepsy-independent pathomorphic findings of Ammon's formation, the correlation with symptomatic epilepsy and the typical psychic disturbance phenomena was studied. While a connection between the lesion and the epileptic disease could be confirmed with a certain probability, this remains problematic with respect to impairments of memory, orientation capacity, working-up of experiences and drive and reaction capacity. Although in all examined subjects clinical deficiency phenomena of one type or the other were present, additional lesions, especially of nuclear regions which are associated with AF and cortical structures will certainly also be responsible.
Despite the still widespread opinion that carotido-basilary anastomosis is exclusively a coincidental finding during angiography or autopsy, reports on the significance of this vascular anomaly in connection with a variety of cerebral symptoms and illnesses have appeared in recent years. These are substantiated by our own observation as an A. primitiva trigemina in connection with brain-organic disturbances in a female patient aged 25 years. In this case it was accompanied by seizures and hemiparesis, the severe neurological deficiencies accompanying the seizures showing a remarkable reversibility.
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The case of an adolescent girl aged 16 with subacute necrotizing encephalomyelopathy (Leigh) is reported. The chronic course of illness lasting for 7.5 years was characterized by visual and gait disorders progressing to blindness, incomplete spastic tetraparesis, and fatal respiratory insufficiency. Neuropathology, in addition to CNS lesions with typical pattern, revealed involvement of Ammon's horn, fornix, corpora mammillaria, tractus mammillothalamicus, and corpus callosum. The massive damage to the total Ammon's horn formation, the distribution of which correlates to none of the established patterns of lesion, is related to the primary disease given, and an additional secondary transneuronal degeneration of associated systems is suggested.
We report on the pathomorphological findings in the optical system, including the ocular muscles, of a girl who died at the age of 15 of subacute necrotizing encephalomyelopathy (Leigh). The first symptom of the disease, which was caused by respiratory insufficiency, was the alteration in visual function seven-and-a-half years previously. In addition, changes in pupillary innervation and disturbances of motility of the eyes were noted during the early stages of the disease and therefore represent an important sign in differential diagnosis. Clinical, pathomorphological and differential diagnosis, aspects of this rare disease are discussed.
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We report on the rare combination of multiple sclerosis (MS) and cerebral glioblastoma in a 50-year-old deceased male. MS was not diagnosed clinically. The particularities of the case in comparison with the known data from the literature are the partly more active MS plaques and extensive necroses of the glioblastoma, especially on the tumourous margins, immediately in the neighbourhood of MS plaques. The possible causes for the unusual coincidence are discussed.
Two cases (a 56-year-old woman and a 57-year-old man) with spinal epidural lipomas are described. In the discussion, the origin, the development and the biological valence of this spinal growth are dealt with. Besides, the age of the manifestation of the neurological symptoms, the localization, the clinical symptoms, diagnosis and differential diagnosis as well as therapy and prognosis of these tumours, which are rarely found in the spinal canal, are discussed. With the exclusion of the lipomatosis combined with lumbosacral malformations of the spinal column, the literature contains reports on about 66 cases of epidural and intradural spinal lipomas described until now.
The paper reports on incidents after direct (percutaneous) carotid angiography. Since the occurrence of the symptoms after the intervention, which was often carried out in patients who were seriously ill, could individual cases only be considered with a certain probability as a consequence of the angiography, our own frequency data are not given. From Juli 1966 to the end of 1978, we carried out a total of 1228 direct carotid angiographies in 1086 patients at our establishment; in 11 persons who died after such an intervention had been carried out, local, sometimes massive pathomorphic findings, in three cases with cerebral complications, were recorded. The necessity of the presence of a correct indication for the performance of this diagnostic method, to which under adequate conditions catheter angiography and--where possible--other diagnostic procedures involving fewer risks should be preferred, is pointed out.
We report on three deceased with pathomorphological findings at the CNS after direct (percutaneous) carotid angiography (d.c.a.). These alterations appeared as complications among 89 decreased with d.c.a. in the time interval from July 1966 to the end of 1978. The diagnostic investigation in the three cases was performed in order to exclude a brain tumour or a vascular disease. In all cases contemporary existed extensive changes at the vessels of the neck due to the angiographic investigation. The autopsy showed signs of a vascular disease in the CNS. For the performance of the carotid angiography an exact indication is necessary. To prevent such serious complications in future, we only can recommend the application of diagnostical methods without any risk.
Report on the neuropathology of 6 fatal cases in 150 stereotactic operations, performed on 135 patients from 1960 to February 1978. The deceased had a hyperkinesis and a severe Parkinson's disease in 3 cases each. Only two of them had died of a complicating intracranial extracerebral haemorrhage immediately after the stereotactic operation. In our own material the longest survival time after operation was about 3 years. Biochemical and biothermical reactions and situations basing on thermocoagulation are dealt with in particular.
The occurrence of unusual peritoneal and subserous deposits of metallic aluminum granules in a 34 years old man after local alugramin treatment of decubital ulcers lasting for about 10 weeks is described. He died of an apallic syndrome approximately 3 months after a head-brain-injury due to an accident and terminal bronchopneumonia. The peritoneal aluminosis was diagnosed at autopsy as a secondary finding. An inflammatory peritoneal reaction was not notified. The lymphatic ganglion system is assumed to be the route of transport.
The author deals with the different and partially divergent aspects of the classification of inflammatory vascular processes with particular reference to cerebrospinal involvement and forms. The limited pathomorphic tissue reaction of vessel wall elements and blood cells to different etiopathogenetic factors and the different cellular tissue structures observed for similar noxae are especially worth mentioning in this context. Also pointed out by the author in his present paper are the limitations of diagnosis. Central-nervous-system involvement usually brings with it special topographic difficulties and problems.
It is reported on 3 observations of isolated granulomatous angiitis of the central nervous system. The case in question was in two 42-year-old men a granulomatous giant cell arteriitis with exclusive affection of the intracranial arteries. In a 33-year-old woman (case 3) there existed a granulomatous angiitis in generalised cerebrospinal granulomatous epitheloid-cellular inflammation (sarcoidosis) of the central nervous system with participation of bifurcal lymph nodes and of the lung. In all the three reports the diagnosis could be made only by autopsy. Clinic, pathomorphology, and diagnostic difficulties are described.
Frequency and appearance of atypical macroglia in the frontal cortex and striatum in 400 human brains of cases with non-hepatogenic diseases were investigated and compared with results in 150 human brains of cases with severe liver diseases. Quantitative and qualitative differences between the non-hepatogenic (I---III) and hepatogenic (IV) groups were statistically significant. Evidence for the so-called Alzheimer-II-cells could only be obtained in metobolic disturbances of hepatogenic origin and in a few cases of cerebral coma.