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Biomedical subjects

R Laky

Publications and source records attributed to R Laky.

18 recordsLinked to original sources

[Septic arthrodesis of the talocrural joint].

Authors report on 20 arthrodeses of the talocrural joint performed in infected surrounding. The accident anamnesis was the following: Talar fracture (3 cases), malleolar fracture (10 cases), "pylon tibial" fracture (7 cases). The operative method was a simple transversal resection and fixation with fixateur externe. The average time of bony fusion was 9.9 months. The patients were controlled in average 3.8 years after the operation. 17 patients could be controlled, all of them could walk. 6 have their original jobs, 4 have an easier work, 7 are invalids. 12 patients have no pains, 5 have major or minor complaints. All patients judge their state as being better than before the operation.

Accidents↗

[Management of dislocated subcapital fractures of the humerus by intramedullary wiring].

Author treated 24 subcapital dislocated humeral fractures with wire fixation of the medullary cavity. The fractures were classified according to Neer. The operation was begun in general anaesthesia with closed reduction; the fixation was made with K-wires through the bone window prepared on the dorsal side of the humerus, above the fossa olecrani. Gymnastics were begun on the 2-3 week. The results were assessed using the point system of Neer. Functional restitution followed in 2-4 months in every patient.

Anesthesia, General↗

[Results of treatment of infected osteosynthesis cases].

At the author's Department 70 infected osteosyntheses were treated. The preliminaries of infection were in 48 cases open, and in 22 cases closed fractures. The original stabilisation was performed in 48 injuried with plates, in 12 cases with intramedullary nails and in 10 other patients with various methods. In 12 cases healing of the infection was reached in a short time. In 58 cases the infection became chronic. In 34 cases the fractures healed in spite of persistant infection, in 24 cases infected pseudarthrosis developed. To reach healing or the definite state frequently more operations were needed. Finally it succeeded to heal both the infection and the fracture in 62 patients. Fistula, resistant to treatment remained in 7 patients.

Adult↗

Aimed application of antibiotics in treating hand infections.

Surgical exploration is of prime importance in treating hand infections. In addition, it is essential to apply up-to-date and adequate antibiotic treatment. Authors employed antibiotics during the treatment of hand infections of 65 various aetiologies and types by considering the antibiotic sensitivity spectrum of the most frequent pathogens as also the effective concentration of the antibiotic acting in the inflammatory focus. For assessing effective antibiotic concentrations, samples were collected during exploration from the inflammatory tissues, and based on their assessments, it was pointed out that an adequate inhibitory antibiotic concentration cannot be reached by each antibiotic by applying it in the usual dose and way. The use of certain antibiotics is recommended in view of the most frequent pathogens of hand infections, of the spectrum of the antibiotic selected by the authors as well as in that of the measured tissue antibiotic concentrations in the dosage used by them. The effective application as well as dosage are also published. Regarding that, in practice, antibiotic treatment should be started according to the nature of the disease without knowing the spectrum of resistance and the pathogen, it is considered important for them to select initially, beside the surgical treatment, an antibiotic which is probably effective and is capable of entering in a sufficient amount the focus of inflammation.

Anti-Bacterial Agents↗

[Model studies of the antibiotic release of gentamycin, tobramycin and cephalothin polymethylmethacrylate beads in vivo].

Gentamycin-, tobramycin-, and cephalothin-polymethylmethacrylat beads were implanted into a bone cavity of the rabbit tibia. The antibiotic release of the implants was observed by measure of the antibiotic concentration of the secretion respectively of the neighbouring bone tissue in the surroundings of the beads produced by punction. An antibiotic concentration about 1 microgram/ml could be measured with gentamycin and tobramycin for 120 to 150 days and with cephalothin for 30 to 50 days in the surroundings of the beads.

Animals↗

[Intra-arterial antibiotic therapy in the management of chronic post-traumatic osteomyelitis of the extremities (experimental and clinical studies].

Authors examined the changes of antibiotic concentration in the inflammatory focus after administering Gentamycin and Cephalothin intravenously or intraarterially in case of experimentally induced osteomyelitis in the tibia of rabbit. Administering Gentamycin i. v. no therapeutic level could be measured, while Cephalothin showed a therapeutic level of antibiotic concentration just for a short period. When the same doses of these antibiotics were administered in the femoral artery, effective local antibiotic concentration could be detected for 3 hours. Authors' clinical studies also support these experimental results. Performing 43 i. a. treatments in 38 patients with osteomyelitis 39 was rated as effective.

Animals↗