Biomedical subjects
Publications and source records attributed to R Lathrop.
A short review of the threading approach to protein structure prediction, including presentation of some open statistical problems. Also discussed is one of the likely sources of the current limited success, that being the form of the pairwise potentials used in most threading approaches.
This paper presents a computational methodology for integrating techniques from protein image interpretation and protein sequence threading, applied to the problem of structure determination from experimental X-ray crystallographic electron density maps. In the proposed architecture, image interpretation of an electron density map produces candidate structural segments; threading is applied to evaluate these hypothesized segments and thus to constrain the set of possible image interpretations. We present the results of experiments designed to test ability of the threading module to discriminate between correct and incorrect alignments of protein sequences onto structural models derived from protein image interpretation. The long-term goal of this research is to improve our ability to determine protein structures from crystallographic data, and to further our understanding of the underlying relationship between sequence and structure.
Populations living close to high-voltage transmission lines often have residential magnetic field exposures in excess of 1 microT, and sometimes over 2 microT. Yet, populations studied in most epidemiologic investigations of the association between residential magnetic field exposure and cancer typically have exposures below 1 microT and frequently below 0.5 microT. To improve statistical power and precision, it would be useful to compare high exposure populations with low exposure populations rather than only studying small differences within low exposure populations. Toward this end, we have developed an automated method for identifying populations living near high-voltage transmission lines. These populations likely have more highly exposed individuals than the population at large. The method uses a geographic information system (GIS) to superimpose digitized transmission line locations on U.S. Census block location data and then extract relevant demographic data. Analysis of data from a pilot study of the populations residing within 100 m of a 29-km segment of one 230-kV line in New Jersey shows that when compared to populations in the surrounding census blocks farther than 100 m from this line, those populations close to the line have similar demographics but differ in terms of perceived housing value variables. We believe that the approach we have developed will enable investigators to rapidly identify and characterize populations living near high-voltage transmission lines on a statewide basis for considering the impact of exposures and for public policy and that these populations also can be used for epidemiologic study.
The contributions to this article show that the perioperative nurse has become a knowledgeable highly skilled practitioner. Nurses with different backgrounds, nationalities, educational preparation, and professional experience show that the outcome--excellent patient care--is more important than the process. Since the individual perioperative practitioner has implemented the nursing process, perioperative nursing care of patients has improved. The primary lesson that the UCIMC administrators learned was that there are many ways to accomplish goals. Administrators commended the perioperative nurses for their knowledge, risk taking, input and assessments related to problems and decisions, and for accepting challenges with enthusiasm and vigor. The administrators also learned that they need to be facilitating supporters more than supervisors in the OR. This creates an appropriate environment for effective practice. In this manner, the perioperative nurse can achieve both personal and professional satisfaction.
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Explore the source record for details and available documents.