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Biomedical subjects

R Laue

Publications and source records attributed to R Laue.

At least 19 recordsLinked to original sources
PubMed1990

[Use of the stable nitrogen isotope 15N in assessing liver metabolism in hormonal contraception].

In 37 women with long-term use of oral contraceptives (average use 13.4 years) and 12 women who had not taken oral contraceptives for at least 5 years we determined the serum enzymes ALAT, ASAT, Gamma-GT and conducted the 15N-ammonium test as a marker of partial metabolic performance of the liver. In addition we studied total protein, protein fractions in the serum and haematologic parameter. 18 out of 37 women showed a morbid result in the 15N-ammonium test. In 4 of these 18 women morphological changes representing hepatic damage caused by contraceptives could be detected. On the average ALAT, Gamma-GT and 15N-ammonium test in both groups are clearly different. Because the enzymic levels are being in the normal range, only the 15N ammonium test enables to give a hepatotoxic evidence. It is possible to conclude that long-term use of oral contraceptives influences the liver metabolism.

Adult↗
PubMed1988

[Resorbate kinetics in the pre- and posthepatic blood compartment in the immediate postoperative phase in swine].

Catheters were implanted in the portal vein by the superior mesenteric vein in pigs for valuation of the absorbant kinetics of enterically applied substances in the mesenteric veins. The blood level kinetics after applying 10 g D-xylose into the jejunum was measured continuously simultaneously in the pre- and posthepatic blood compartment 6, 24, 36, 48, and 72 hours after the operative procedure. An enteric resorption of the pentose is provable already 6 hours after the operation, with their utter normalization in the next 36 hours. The differences between the pre- and the posthepatic concentration-time-graphs admits conclusions on the metabolism of the absorbant in the liver.

Animals↗
PubMed1986

[Enteral resorption kinetics in the aging process].

With growing age functional and morphological changes in the alimentary tract appear. The age dependence of the intestinal absorption was investigated with the help of the modified D-xylose absorption test. By means of a graphic-mathematical evaluation of the blood level kinetics of D-xylose after oral and intravenous application the absorption rapidity (constant k12), the temporary position of the relative maximum of the D-xylose concentrations in the blood serum after oral application (time tm) and the size of the relative absorption of the small intestine were established depending on the time RR (t). Within the age range of 3 to 96 years it has been proven that a slowing down of the enteral absorption occurred with growing age. By prolonging the period during which the food components are absorbed in the small intestine (shift of tm towards later times) the old organism is just as capable of complete absorption as is the young one, even though the absorption processes take place at a slower rate. Absorption disorders in old age are due to morbidity and not, sui generis, to involution.

Adolescent↗
PubMed1986

[Alcohol induced damage to the pancreas in patients with increased blood alcohol levels detected in road traffic].

50 patients, driving motor-cars, having increased blood alcohol levels, were registrated and prosecuted. They voluntary underwent catamnestic researches for early diagnosis of alcohol induced lesions of the pancreas. In relation to the habitual drinking systems the study concluded 28 (56 per cent) healthy persons, 13 (26 per cent) alcohol endangered cases, 9 (18 per cent) alcoholics. Various biochemical parameters were changed, liver histomorphology resulted in about 50 per cent of cases a fatty degeneration of the liver and hepatitis. Special diagnostic methods (CCK-test, ERCP, ultrasound echography, computer-tomography) submitted in 24 per cent of cases suspect of alcohol induced pancreatitis. Results, which promote alcoholic pancreatic damage, are being discussed.

Adolescent↗
PubMed1979

[Enteral resorption and tumor cachexia].

The rapid loss of the body weight of oncological patients in the advanced stage of the carcinomatous disease is caused by numerous pathophysiological mechanisms. With the help of the modified D-xylose absorption test was investigated which value have disturbances of the enteral absorption in the complex of causes for the development of a tumour cachexia. For the patients in the stage of generalisation of the carcinomatous disease clear disturbances in the enteral food intake could be proved in contrast to patients with carcinoma without general tumour symptomatology and healthy persons. The influence of chemo- and radio-therapy on the enteral absorption of patients with carcinoma was discussed. The forced alimentation of oncological patients with unspezific tumour symptoms must be regarded as a firm constituent in the treatment of patients with carcinoma.

Cachexia↗
PubMed1979

Effect of temperature on the transcription by bacteriophage T3-induced RNA polymerase.

Bacteriophage T3-induced RNA polymerase is rapidly inactivated at 42 degrees C. Addition of T3 DNA delays this process for 30 s and reduces the rate with which the enzyme activity is lost indicating that a labile binary complex between T3 DNA and polymerase must have been formed. The ternary complex between T3-specific RNA polymerase, T3 DNA, and nascent RNA chains obtained when the enzyme is incubated with T3 DNA, GTP, ATP, and UTP is stable to heat (42 degrees C) and only slowly inactivated by polyvinyl sulfate. The optimal temperature for the formation of polyanionresistant ternary complexes is 30 degrees C while the elongation of T3 RNA chains proceeds fastest at 38 degrees C.

Cell-Free System↗
PubMed1979

[Postoperative small intestinal absorption after cholecystectomy].

The postoperative resorption in the small intestine after cholecystectomie was found out by means of the modified D-xylose resorption test on the 2-th, 4-th, 6-th an 8-th postoperative day for 14 patients. The velocity and the dimension of the enteral resorption of D-xylose was lower in the immediate postoperative phase. The dimension of the D-xylose resorption was normalized on 4. p. o. day and obtained the preoperative starting-value on the 8-th postoperative day. The myoelectrical activity of the small intestine normalized in a shorter time after cholecystectomy than the enteral resorption. A formal parallelism consists between the normalisation of the motoric activity of the stomach and the xylose-resorption in the immidiate postoperative phase. For the small intestine resorption in the postoperative phase completely clarified and required further investigations. The influences of electrolyte displacement and disturbances of the microcirculation in the postoperative period in the small intestine resorption were discussed.

Adult↗
PubMed1979

[Postoperative intestinal absorption in old age (author's transl)].

The function of intestinal absorption was analysed in elderly patients before and after cholecystectomy by the help of the modified D-xylose-absorption test. A characteristic dependence upon the age for the process of intestinal absorption was demonstrated in the elderly not only preoperatively but also postoperatively. The effective intestinal absorption of D-xylose normalized postoperative by in freshly operated older patients more slowly than in younger ones.

Aged↗
PubMed1978

[Digestion and absorption in elderly man (author's transl)].

Morphologically first indications of an age-related alteration of pancreatic microscopic structures can be proved an age of fourty. In healthy elderly man functional capacity of exocrine pancreas is lowered. It can be proved by means of pancreatic function tests. Normally the digestive capacity will be sufficient provided a reasonable nourishment. Usually the intestinal absorptive capacity tends to decrease in the elderly. But following delayed intestinal transit of nutritients absorption to a certain degree can occur sufficiently. Considering the nutrition of elderly people recommendations are given.

Age Factors↗
PubMed1978

[Initial results of investigations into the proliferation kinetics of enterocytes (author's transl)].

The changes of absorption appearing in man and caused by aging are probably due to disturbances of the proliferation and exfoliation kinetics of the enterocytes of the small intestine mucosa. The relevant experimental examinations available are insufficient because the results were obtained from a few animals only. Our own systematic autoradiographic examinations of rats are designed to contribute to a clarification of this problem which is important for practice.

Adolescent↗
PubMed1978

[Intestinal absorption in the elderly (author's transl)].

The extent of intestinal absorption and malabsorption may be exactly stated by means of the method "generalized absorption". According to first-hand examinations an alteration of absorbing kinetics of D-xylose dependent on age could have been demonstrated. The velocity of absorption decreases in the elderly and the general absorbing process are prolonged. The extent of absorption restriction in the elderly are under physiological circumstances without clinical value. The health elder man disposes of the same power for a complete absorption of an offered substrate like the younger one. An increasing of cases with a malabsorption in the age may be explained by a increased multmorbidity in the elderly.

Adolescent↗
PubMed1976

[Aging and resorption].

The enteral absorption in dependence of age has been tested by D-xylose. From the additional investigation of the D-xylose reaction in the blood plasma one can detect statistically ascertained age relation in comparison between young and old healthy test persons. Though in old age the absorption process is retarded a sufficient absorption at a longer time at diminished speed of passage of the ingesta in old age.

Adolescent↗
PubMedDate not supplied

[Aspects of healthy and pathologically changed laryngeal epithelium in a model. 2].

Atrophy of laryngeal epithel at aged men can in model according to the literature lead back on prolongation of mitosis cycles. An increasing tendency of cornification and decreasing formation of pegs in range of basilar membrane are also demonstrable. Formation and development of a tumor instance a pathological evolution of tissue in model.

Aging↗
PubMedDate not supplied

[Relations between disordered exocrine pancreas function, alcohol consumption and age in alcoholics].

During clinical withdrawal treatment, a disturbed exocrine pancreas function was found in 28 per cent of 72 alcohol addicts, which occurred in connection with an alcohol-induced pancreatitis. The clinical course was mainly quiescent. Altered bicarbonate concentrations and enzyme dissociations were found as a result of the secretin pancreozymin test. In alcohol addicts, the maximum activity of the amylase output was reached as early as 20 minutes and that of bicarbonate, trypsin and chemotrypsin not until 40 minutes post stimulationem. The sums of the logarithmically transformed 40-minute output of bicarbonate, amylase and trypsin displayed significant differences between the alcohol-addict and control groups. The degree of severity of the disturbed exocrine pancreas function was essentially a function of the daily amount of alcohol taken by the addict and of the age of the patient. The dysfunction was most evident in the 30-to-50-year-old patients. Chronic consumption of alcohol is assumed to give rise to a selective effect on the hydro-kinetic and ecbolic pancreas function.

Adolescent↗