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Biomedical subjects

R Lenkei

Publications and source records attributed to R Lenkei.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Diversity of the anti-HBc response and its correlations with other immunological parameters in asymptomatic HBsAg carriers.

The anti-HBc response was investigated by immunofluorescence in the sera of 109 asymptomatic HBsAg carriers. The results suggest the presence of at least two antigenic HBcAg determinants, possibly correlated with the replication phase. The subjects with intensive anti-HBc response showed immunological alterations consistent with the presence of active liver lesions and of hepatocellular membrane injury.

Antibodies, Viral↗
PubMedDate not supplied

[Splenectomy in chronic hepatitis with an autoimmune component].

The authors present a synthesis of studies performed on the role of the spleen in chronic active-digestive hepatitis with auto-immune participation. The study was based on a group of 48 patients out of which a lot of 20 patients was selected, with histological diagnosis of chronic active and aggressive hepatitis, in whom the presence of AgAu was ascertained, as well as of antiliver antibodies. From the immunological viewpoint, the effect of splenectomy was manifested, by a rapid and significant decrease of anti-liver antibodies mainly produced by the spleen, immediately following the intervention. In most of the patients the IgM antibodies disappeared somewhat later. At the same time the chronic hepatitis lesions were stabilized, the biological signs were improved and the clinical evolution of the patients was good. The authors consider that splenectomy in this category of hepatopathies is an immuno-suppressive therapy that may arrest the evolution towards cirrhosis.

Adult↗
PubMedDate not supplied

A new antigen/antibody system--the polymerized albumin and antialbumin antibodies.

Two new antigenic determinants have been identified on serum albumin molecules originating from hepatic patients. The same antigenic determinants may be induced on serum albumins of different species by in vitro aging or glutaraldehyde treatment. In patients with liver cell dysfunction the new antigenic sites of the albumin molecules induce the synthesis of specific antipolymerized albumin antibodies (AAA) identified by precipitation and hemagglutination methods. The anti-polymerized albumin precipitins (AA-P) reveal with high specificity and sensitivity the presence and severity of liver cell dysfunction. In patients with active liver diseases (acute viral hepatitis and chronic aggressive hepatitis), both precipitins and agglutinins show high titers, while in patients with severe liver diseases and long evolution or in old-agers AA-P positivity is seldom associated with anti-polymerized albumin agglutinins.

Adult↗
PubMedDate not supplied

Apparently healthy HBsAg carriers: sex-dependent difference in ABO blood group distribution, subtype ratio and antigen titer.

The results obtained by subtyping and titration of 872 HBsAg from apparently healthy carriers were grouped according to blood group and sex. The incidence of blood group AB is higher among healthy HBsAg carriers than in the unselected population. There are large variations as regards the ay : ad ratio (overall mean value : 4.74) : minimal ay : ad values occur in the AB blood group, both in men (4.00) and in women (1.33), as compared with the mean values of 5.07 and 2.95 recorded in men and women, respectively. Titer analysis shows a cluster of higher titers in women. The involvement of immunogenetic mechanisms in asymptomatic HBsAg carriage is suggested.

ABO Blood-Group System↗
PubMedDate not supplied

HBs antigen and blood glucose concentration.

HBsAg presence was studied by counterelectrophoresis (CEP) in 76 patients with liver cirrhosis and in 431 patients with diabetes mellitus. A striking correlation was found between high blood glucose values and HBsAg absence. Thus, HBsAg-negative cirrhotics (53%) had significantly higher levels of glycemia than the HBsAg-positive patients of the same age group, i.e. 95.75 +/- 6.36 ng/100 ml compared to 78.30 +/- 10.2/100 ml. This absence of HBsAg was also observed in all diabetics but one. As the incidence of HBsAg (CEP) was found to be of 3.63% in 253,460 subjects from different areas of Romania and 6.84% in 14,690 subjects with various non-hepatic diseases included, the chance of finding the 0.2% HBsAg incidence observed in the diabetics would be less than 0.0002 and 0.0001, respectively. The serum HBsAg absence in cirrhotics with high glycemia and in diabetics strongly incriminates the constant high concentrations of blood glucose as the main factor responsible for this negativity. The effect may be direct on virus replication, or indirect, by metabolically-induced hepatic dysfunction interfering with HBsAg secretion or excretion. The presence of high concentrations of glucose in cell culture media might explain the repeated failure of hepatitis B virus serial passage in tissue or organ culture.

Adolescent↗
PubMedDate not supplied

Beta2-microglobulin excretion and autoimmune phenomena in endemic Balkan nephropathy.

Quantitative determinations of beta2-microglobulins were carried out in 335 urinary samples collected from 335 subjects living in villages with a high rate of morbidity and mortality from endemic Balkan nephropathy. Three months after the first determination of beta2-microglobulin excretion, blood and urine samples were obtained from 19 patients with high values and from 19 with normal values of beta2-microglobulins. The results of the biochemical and immunological investigations performed on these samples suggest that the tubular alteration is the first lesion. The autoimmune phenomena elicited by the tubular alteration may contribute, by an antigen-antibody complex disease mechanism, to the appearance of glomerular secondary lesions.

Antigen-Antibody Complex↗