The surgical treatment of aortic aneurysms.
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Aorta, Abdominal↗
Biomedical subjects
R Lev
Publications and source records attributed to R Lev.
The mucin histochemistry of normal and neoplastic gastric mucosa.
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Epithelium↗
Fetal absorption of 3H-leucine injected into the amniotic sacs of pregnants rats.
When injected into the amniotic sacs of fetal rats in late pregnancy, 3H-leucine is rapidly absorbed and incorporated into fetal proteins as determined by liquid scintillation spectrometry. Peak values in the fetal liver and pancreas occur around four hours after injection. Approximately 21% of the radioisotope is retained in the injected fetus at 24 hours. The remainder escapes into the maternal circulation and accounts for a gradual increase in levels in noninjected fetuses from the same litter and for persistently high counts found in maternal serum as late as 24 hours after the injection. Specific activity of the radioisotope in fetal tissues is considerably higher (100- to 200-fold) when 3H-leucine is injected inth the amniotic sac rather than intravenously into the mother. The possible treatment of various fetal disorders by means of intra-amniotic injections is discussed.
Absorption↗
Neuroleptic malignant syndrome presenting without fever: case report and review of the literature.
The case of a patient with neuroleptic malignant syndrome (NMS) and delayed fever is presented. The patient was on lithium and trilafon before presentation to the emergency department with altered sensorium, rigidity, drooling, and tachycardia. The patient remained afebrile for 9 hours in the emergency department. He responded to treatment involving discontinuation of neuroleptics and bromocriptine. Typically NMS presents with a tetrad of fever, rigidity, altered sensorium, and autonomic dysfunction. This case is an example of NMS with delayed fever. A review of the literature on neuroleptic malignant syndrome is also presented.
Adult↗
Prophylactic lidocaine use preintubation: a review.
This article is a review of the use of prophylactic lidocaine as a preintubation medication. Intubation is associated with a cardiovascular response of elevated blood pressure and pulse, cough reflexes, occasional dysrhythmias, increased intracranial pressure, and increased intraocular pressure. In patients with atherosclerotic heart disease, potential intracranial lesions, and potential penetrating eye injuries, these responses to intubation are of greater risk. Various studies have reviewed the effect of lidocaine to blunt these responses. It is agreed that lidocaine blunts cough reflexes and dysrhythmias. Some studies note a response of lidocaine in blunting rises in pulse, blood pressure, intracranial and intraocular pressure. No studies document any harmful effects of prophylactic lidocaine given preintubation. A dose of prophylactic lidocaine of 1.5 mg/kg given intravenously 3 minutes before intubation is optimal. For suctioning of intubated patients, lidocaine can be given endotracheally in a 5-6 mg/kg dose diluted in 6 cc via simple administration at the entrance to the endotracheal tube.
Hemodynamics↗
Visine overdose: case report of an adult with hemodynamic compromise.
Imidazole decongestants are present in a variety of over-the-counter medications, including eye drops and nasal sprays. Their primary mechanism of action is vasoconstriction, accomplished by direct stimulation of alpha receptors on blood vessels. Accidental and intentional poisonings involving these substances are increasing, and can cause mental status and respiratory depression, as well as other effects related to alpha receptor stimulation. We present a case of tetrahydrozoline ingestion in an adult who presented with chest pain, bradycardia, mental status depression, miosis, and other signs and symptoms of imidazole compound poisoning. It is important for physicians to be familiar with the adverse effects of these ingestions and to be aware of the potential therapies for management.
Administration, Oral↗
Eosinophilic gastroenteritis with malabsorption, extensive villous atrophy, recurrent hemorrhage and chronic pulmonary fibrosis.
A patient with diffuse eosinophilic gastroenteritis, associated with progressive chronic interstitial pulmonary fibrosis, was followed for 29 years. His major symptoms were recurrent gastrointestinal bleeding, anemia, diarrhea, malabsorption, and increasing respiratory insufficiency. Multiple jejunal biopsies revealed eosinophilic infiltration and extensive villous atrophy. Results of a lung biopsy and pulmonary function tests were consistent with chronic interstitial pulmonary fibrosis. His gastrointestinal symptoms responded to steroid therapy, but he died of progressive respiratory insufficiency. At autopsy, villous atrophy was noted to extend throughout the whole extent of the small intestine in association with multiple "pseudopolypoidal" inflammatory lesions.
Aged↗
Histochemical and morphological analysis of colonic epithelium from children with Gardner's syndrome and adults bearing adenomatous polyps.
Normal and adenomatous colonic tissues from children with Gardner's syndrome were compared to analogous tissues from adults bearing adenomatous polyps using mucin histochemical and lectin-binding techniques. Adenomatous tissue from children exhibited general morphological similarity to its adult homologue, but showed less dysplasia. Its goblet cells stained weaker for mucins and the lectins Dolichos biflorus agglutinin (DBA) and peanut agglutinin (PNA). This suggested underglycosylation of side chains of mucins in these childhood adenomas. The weak DBA and relatively intense sulfomucin staining in these adenomas suggested that they arose from deep crypt cells. Adult adenomas shared certain histochemical properties with carcinomas, namely, increased affinity for periodic acid-Schiff (PAS) and focally for PNA. There is evidence based on the effects of saponification and sialidase treatments that the weak initial PAS reaction in normal and adenomatous colonic goblet cells from both age groups results from substituents on sialic acid and, in the case of normal colon from children, on other monosaccharides as well. Finally, there was a frequent lack of parellelism between PAS and lectin staining suggesting that different groups within the sugars are responsible for reactivity with those compounds.
Acetylgalactosamine↗