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Biomedical subjects

R Lew

Publications and source records attributed to R Lew.

At least 109 records · Page 6Linked to original sources
PubMed1978

Major loci for lipoprotein concentrations.

In more than 500 families of Japanese ancestry, selected in part through fathers with hyperlipemia or coronary heart disease, a major locus for hyper-beta-cholesterolemia (hyperlipoproteinemia type IIa) is highly significant (chi22 = 24.02), with an allele frequency .002 in the general population. This gene is revealed with about the same power by fasting levels of LDL (low density lipoprotein) cholesterol and total cholesterol. However, VLDL (very low density lipoprotein) cholesterol, HDL (high density lipoprotein) cholesterol, and triglyceride give no convincing evidence for a major locus in this population, nor was a gene for combined hyperlipoproteinemia detected.

Female↗
PubMed1977

Colchester revisited: a genetic study of mental defect.

This reanalysis of a classic survey leads to inferences about design of genetic studies, resolution of heterogeneity, and the role of autosomal and sex-linked genes in mental retardation, which is no longer refractory to segregation analysis. By discriminating between sociofamilial and biological types we estimate that at least 351 autosomal loci can produce mental retardation, with an inbred load of 0.83 detrimental equivalents and a mutation rate of 0.008 per gamete, or less than 2.4 X 10(-5) per locus. The distribution of probands was estimated as: 7 per cent medical, 60 per cent sociofamilial, and 33 per cent biological. Simple genetic mechanisms account for virtually all the biological category. Within the sociofamilial group cultural inheritance and polygenes could not be resolved.

Consanguinity↗
PubMed1977

Commingling in distributions of lipids and related variables.

In a sample of nearly 8,000 Japanese males, the distributions of casual cholesterol and triglyceride, hematocrit, glucose, uric acid, diastolic blood pressure, and weight (covariance adjusted) could not be normalized by a power transform and were significantly better fitted by a mixture of distributions. The evidence for admixture was nonsignificant for systolic blood pressure, significant but unimpressive for height and weight, and strong for the remaining variables. The minor component corresponded to high values, in low frequency except for triglyceride and glucose. These results favor an interpretation of elevated levels in terms of distinct entities, genetic or environmental or both, rather than cumulative small effects only. These entities appear to be megaphenic (i.e., with effects exceeding one phenotypic standard deviation). Consequences of this hypothesis are discussed.

Aged↗
PubMed1975

Analysis of family resemblance. IV. Operational characteristics of segregation analysis.

In simulated data, segregation analysis of quantitative traits was found to be powerful for resolving a major locus from polygenic and cultural inheritance. It is reasonably robust against a variety of deviations from the model if and only if a major locus, polygenic heritability, and environment common to sibs are simultaneously included in the model, and heterogeneity tests among mating types are performed. Most of the information in quantitative data about a major locus is lost when reduced to affection status.

Environment↗
PubMedDate not supplied

Mammography and clinical breast examination among Korean American women in two California counties.

BACKGROUND: Mammography and clinical breast examination (CBE) are underutilized, especially by women from some racial/ethnic minorities. Few published studies of screening practices or correlates for these subgroups exist. METHODS: A population-based telephone survey of 1,090 Korean Americans living in two California counties was conducted. To produce population estimates of mammography and CBE testing, we adjusted frequencies to account for different selection probabilities. Multivariable logistic regression was performed to determine independent correlates of testing. RESULTS: Only 34% [95% confidence intervals (CI) 30%, 39%] of Korean American women age 50 and older were estimated to have had a mammogram in the past 2 years. Only 32% (95% CI 28%, 37%) had had a CBE in the past 2 years. The strongest independent correlate of testing was having a regular medical checkup [odds ratio (OR) for mammogram = 9.21, 95% CI 3.98, 21.35; OR for CBE = 11.58, 95% CI 4.71, 28.46]. CONCLUSIONS: These estimates are lower than the Healthy People 2000 objectives as well as published estimates for other populations in the United States. Planning and implementing tailored programs to improve screening are best done using a community-sensitive approach, which, because racial/ethnic subgroups are growing, will assume increasing public health importance.

Aged↗
PubMedDate not supplied

Correlates of cigarette smoking among Korean American adults in Alameda County, California.

OBJECTIVE: To estimate the prevalence of cigarette smoking and to determine the sociodemographic correlates of smoking among Korean American adults in Alameda County, California, 1994-1995. METHOD: Korean surname-based telephone survey; contingency table and multinomial logistic regression analyses. FINDINGS: Almost 39% of Korean American men and 6% of Korean American women were current smokers. Among Korean American men those who attended religious activities less than monthly had nearly three times the odds of being current smokers, and those who did not speak English well had 2 1/2 times the odds of being current smokers as compared to never smokers. Those 18 to 24 years of age had more than 8 1/2 times the odds, and those who attended religious activities less than monthly had more than 3 1/2 times the odds of being current smokers as compared to former smokers. Among Korean American women those who were not married had more than 3 times the odds of being current smokers, and those who attended religious activities less than monthly had 22 times the odds of being current smokers as compared to never smokers. Those who attended religious activities less than monthly had almost 8 times the odds of being current smokers as compared to former smokers. CONCLUSIONS: This study increases our understanding about the prevalence and correlates of cigarette smoking among Korean Americans and can contribute to the development of effective smoking cessation and prevention strategies in this understudied population.

Adult↗
PubMedDate not supplied

Using a stages of readiness model to address community capacity on tobacco control in the Asian American and Pacific Islander community.

OBJECTIVES: This paper describes the Asian Pacific Partners for Empowerment and Leadership (APPEAL) Stages of Community Readiness Model, a framework for assessing and evaluating tobacco control in the diverse Asian American and PaCific Islander (AAPI) communities. METHODS: This model extends the work of existing community capacity models by applying a "stage of readiness" continuum of the five stages of pre-contemplation, contemplation, preparation, action and maintenance in terms of developing, launching and sustaining AAPI tobacco control efforts. FINDINGS: The APPEAL Model allows communities to diagnose, then address their unique needs through appropriate technical assistance, training and resources. The APPEAL Model benefits both communities and funders through its ability to better understand their readiness to conduct tobacco control and have realistic expectations on the outcomes of those efforts. CONCLUSIONS: This paper describes the elements of the Readiness model for AAPIS, particularly those addressing research and data issues, current applications of the model in specific AAPI ethnic communities, and the lessons learned thus far regarding the model's applicability to, and support of, the development of AAPI tobacco control efforts nationally.

Asian↗