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R Licastro

Publications and source records attributed to R Licastro.

5 recordsLinked to original sources
PubMed1988

[Ulcerative colitis in children. Levels of salicylazosulfapyridine and sulfapyridine during treatment].

Salicylazosulfapyridine (SASP) is a drug used in the treatment of ulcerative colitis (UC) owing to the therapeutic action of the 5-aminosalicylic acid produced by the splitting of the molecule in the cecum, which also yields the absorbable compound Sulphapyridine (SP). The aim of our work was to assess the levels of the drug in blood (SASP and SP), to correlate them with undesirable effects in any, to verify their fluctuations in the dosing interval and to investigate the extent of the excretion of the drug in the children who were studied. 10 children (6 to 16 years) with UC, who were treated with SASP (dOsage schedule 0.5-2.0 g/day in a 12 hours interval), were studied. Blood levels of SASP and SP were assessed at 6 and 12 hours after doses, and total fecal excretion of SASP was determines in 24 hs specimens. All the determinations were performed according to Hansson and Sandberg. SP plasma levels were 17.7 +/- 9.0 ug/ml (range 6.8-36.3 ug/ml) at 6 hours after doses. and 14.1 +/- 7.2 ug/ml (range 5.7-25.0 ug/ml) at 12 hours after doses. SASP plasma levels were 15.5 +/- 15.4 ug/ml (range 2.1-53.4 ug/ml) at 6 hours after doses, and 14.0 +/- 20.4 ug/ml (range 3.9-70.7 ug/ml) at 12 hours after doses. The 24 hours fecal excretion was 17.4 to 236 mg. These values were correlated with the given doses (r = 0.88) calculated as SASP g/m2 body surface 24 hs. There was no statistical correlation between doses and SP or SASP levels in this group, and the respective levels of SASP and SP at 6 and 12 hours after doses showed no significative differences.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

[Determination of amylase creatinine clearance in children and adolescents].

UNLABELLED: 24 children whose ages ranged from 10 days to 14 years (x 5.5. ys.), 16 males and 8 females, hospitalized in our Service on account of extra-digestive were studied. Creatinine and amylase determination were performed on serum and 24 hs. urine specimens; lipase activity was measured only in serum. Amylase-creatinine clearance ratio varied between 1.3 and 5.8% (x 3.1 +/- 1.3). Serum amylase ranged from 36 to 460 U/l (x 123 U/l). Five patients had hyperamylasemia. 2 were urlian parotiditis, 2 were under clinical surveillance after surgery and the last one was a septic meningitis. All of them showed amylase-creatinine ratio values up to 2.5%. Serum lipase ranged from 6 to 197 U/l (x 79 U/l), falling into the normal interval. No abnormal clearance was found. CONCLUSIONS: hyperamylasemia is not specific for pancreatic disturbances in children; the serum lipase and the amylase-creatinine clearance ratio seem to be useful tools to rule out pancreatic involvement in hyperamylasemic patients.

Adolescent↗
PubMed1979

[Rectal tonometry in the differential diagnosis of constipation in pediatrics].

Based on the difficulties regarding the clinical, radiological, and histological diagnosis of colonic aganglionosis, we resorted the motility studies. Sixty-two children (15 days-10 years of age) were studied by means of rectal motility without knowing the results of the other auxilary methods. We obtained a clear difference between aganglionic and other group formed by constipated functional or psicogenic. We conclude that rectal motility studies have the advantage of being rapid and non-aggressive, besides avoiding rectal biopsy.

Child↗
PubMed1978

[Radiologic diagnosis of Meckel's diverticulum].

This paper describes our experience with pre-surgical diagnosis of Meckel's diverticulum. We used a naso-jejunal-ileal tube, through which, we injected small amounts of radio-opaque fluid and air, thus utilizing double contrast. In seven children diverticulum was shown to be present by radioscopic and radiographic techniques; this was later confirmed during laparotomy. X-ray findings were compared with Tc99 scanning results.

Child↗