PubMed Health⌕ Search

Biomedical subjects

R Lind

Publications and source records attributed to R Lind.

10 recordsLinked to original sources
PubMed2003

Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila.

Insecticide resistance in laboratory selected Drosophila strains has been associated with upregulation of a range of different cytochrome P450s, however in recent field isolates of D. melanogaster resistance to DDT and other compounds is conferred by one P450 gene, Cyp6g1. Using microarray analysis of all Drosophila P450 genes, here we show that different P450 genes such as Cyp12d1 and Cyp6a8 can also be selected using DDT in the laboratory. We also show, however, that a homolog of Cyp6g1 is over-expressed in a field resistant strain of D. simulans. In order to determine why Cyp6g1 is so widely selected in the field we examine the pattern of cross-resistance of both resistant strains and transgenic flies over-expressing Cyp6g1 alone. We show that all three DDT selected P450s can confer resistance to the neonicotinoid imidacloprid but that Cyp6a8 confers no cross-resistance to malathion. Transgenic flies over-expressing Cyp6g1 also show cross-resistance to other neonicotinoids such as acetamiprid and nitenpyram. We suggest that the broad level of cross-resistance shown by Cyp6g1 may have facilitated its selection as a resistance gene in natural Drosophila populations.

Animals↗
PubMed1996

Evidence of myocardial injury during prolonged strenuous exercise.

These preliminary data suggest that extremely prolonged intense exercise may induce subclinical myocardial injury. Although questions of assay interference exist, the importance of this finding has prompted planning of a larger study using a methodologically more specific assay.

Biomarkers↗
PubMed1986

Comparison of the pattern of early revascularization of conventional versus vascularized nerve grafts in the canine.

Blood flow to both conventional and vascularized canine saphenous nerve grafts was quantitated at two, 24, and 72 hours postoperatively, using radionuclide-labeled microspheres. For all time periods vascularized nerve grafts demonstrated adequate blood flow equal to or exceeding normal nerve controls. In contrast, conventional nerve grafts exhibited no significant fascicular revascularization in the first 24 hours, and only one of three dogs demonstrated adequate blood flow by three days postoperative.

Animals↗
PubMed1985

Ticarcillin plus clavulanic acid (Timentin) therapy for osteomyelitis.

Timentin is an exciting new antibiotic agent that is a combination of ticarcillin and clavulanic acid. Forty-seven patients with osteomyelitis received 3.1 g of Timentin intravenously every six hours. The mean duration of therapy was 32 days. The diagnosis was made by bone biopsy; bone biopsy was repeated at the completion of therapy. The bacterial etiology was predominately gram-positive organisms. Of the organisms isolated, Staphylococcus aureus was the most common isolate and represented 39 percent of the total isolates. Streptococcus species were isolated in 13 percent, Group D Enterococcus in 15 percent, Pseudomonas aeruginosa in 10 percent; 23 percent of the isolates were other gram-negative organisms. All but one organism were initially sensitive to Timentin. Three resistant organisms were isolated during therapy. Twenty-seven patients were classified as having a cure, based on no growth on repeat bone biopsy cultures and clinical signs of bone healing. Twenty-two patients returned for follow-up (one to nine months after therapy) and had no evidence of infection; however, because of the short follow-up period, these patients were classified as showing improvement. Six patients had adverse reactions to Timentin: two had mild allergic phenomena and two had prolonged bleeding times. In all four, therapy was discontinued. Two patients had a transient, mild elevation in the level of serum glutamic-pyruvic transaminase (less than twice normal levels). This new agent looks exciting for therapy of both gram-positive and gram-negative bacterial osteomyelitis.

Adolescent↗
PubMed1985

A phase II study of high-dose estrogens (diethylstilbestrol diphosphate) in prostate cancer.

Twenty-five patients with metastatic prostate cancer resistant to primary hormone therapy, received high-dose intravenous diethylstilbestrol diphosphate (Stilphostrol [Miles Pharm], DES-P) in a Phase II study using established response criteria. Objective response rate was 17%, while 22% of the patients were subjectively improved. Moderate gastrointestinal toxicity was reported in 10 patients (40%). Thromboembolic complications were seen in 2 (8%). The role of high-dose Stilphostrol in the treatment of hormone-resistant prostate cancer is limited.

Acid Phosphatase↗
PubMed1984

Interpretation of Doppler segmental pressures in peripheral vascular occlusive disease.

Measurement of Doppler segmental arterial pressures in the lower extremity using narrow pneumatic cuffs has become a standard noninvasive diagnostic technique. Correlation between arteriographic and noninvasive studies was available for 345 aortoiliac segments and 326 femoropopliteal segments. If stenoses of 50% or greater and occlusions were considered hemodynamically significant, the sensitivity to aortoiliac disease was 97%, but only 67% to femoropopliteal disease. The specificity for hemodynamically insignificant disease was 50% and 68%, respectively. Accuracy was influenced by the presence of associated aortoiliac or femoropopliteal disease. The sensitivity to hemodynamically significant femoropopliteal disease was 55% if there was associated aortoiliac disease, and 89% in its absence. In the presence of significant femoropopliteal disease, specificity for the absence of aortoiliac disease decreased from 70% to 41%.

Angiography↗
PubMed1984

Decreased serum phosphate levels after high-dose estrogens in metastatic prostate cancer. Possible implications.

Hypophosphatemia and osteomalacia have been described in patients with metastatic prostate cancer. The mechanism of hypophosphatemia in prostate cancer is not known. A decrease in serum phosphate levels was observed in 16 of 18 patients with metastatic prostate cancer treated with high-dose diethylstilbestrol diphosphate. To determine if the fall in serum phosphate was indeed due to diethylstilbestrol diphosphate, the data from several similar groups of patients treated with chemotherapy and combined chemohormonal therapy that included diethylstilbestrol diphosphate were re-examined. Fifty-eight patients were treated with doxorubicin, doxorubicin plus cis-platinum, doxorubicin plus diethylstilbestrol diphosphate, or diethylstilbestrol diphosphate alone. A significant decrease in serum phosphate levels was seen only in patients treated with diethylstilbestrol diphosphate. Hypophosphatemia and possibly osteomalacia in metastatic prostate cancer may be related to estrogen therapy.

Aged↗
PubMed1984

Primary choriocarcinoma of the urinary bladder in association with undifferentiated carcinoma.

A carcinoma of the urinary bladder with a distinct choriocarcinomatous component that developed in a postmenopausal woman was associated with high titers of circulating chorionic gonadotropin. The diagnosis was supported by histochemical demonstration of human chorionic gonadotropin in syncytial tumor giant cells and electron microscopic features consistent with syncytiotrophoblastic cell differentiation.

Carcinoma↗