Sex hormone response to alcohol.
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Biomedical subjects
Publications and source records attributed to R Lindman.
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Tne anatomy of the human trapezius muscle is complex, with an extensive origin and fibers running in different directions. The muscle is commonly divided into three different muscle portions according to the fiber direction: the descending, transverse, and ascending portions. In a previous study in males, the structure of the muscle differed between different portions with respect to the enzyme-histochemical fiber-type profile. The lower regions of the descending portion and the transverse and the ascending portions had a predominance of type I fibers. The type II fibers were more frequent in the upper regions of the descending portion, and the cross-sectional fiber area in this region of the muscle was smaller. In this study, we have investigated the trapezius muscle in females and compared the results with those from males. The different portions of the female muscle had a relatively even fiber-type composition. However, there tended to be fewer type I fibers and more type IIB fibers in the descending portion of the muscle, and the fibers of the lower regions of the descending portion were somewhat larger. The fiber-type distribution pattern was similar to that of the male trapezius muscle, but the mean cross-sectional area of the fibers in the female muscle was considerably smaller. Thus, our conclusion is that the trapezius muscle of females has a similar activity pattern as that of males. The significantly smaller cross-sectional fiber area, however, may indicate a lower functional capacity which may be of importance in the development of neck and shoulder dysfunction in females.
Muscle biopsies of the descending portion of the trapezius muscle from female patients with chronic trapezius myalgia and from healthy women were analyzed with enzyme histochemical and immunohistochemical methods. Frequency, area, and capillarization of the muscle fiber types were determined. A biochemical analysis determined the lactate concentration of mixed muscle samples and the adenosine triphosphate (ATP) and phosphocreatine levels in single muscle fibers. The patients had larger type I fibers and a lower capillary:fiber area ratio for type I and type IIA fibers. The patients also exhibited lower levels of ATP and phosphocreatine in both type I and type II fibers. It is suggested that there might have been an imbalance between the capillary supply and the cross-sectional fiber area of type I and type IIA fibers in the patients. This imbalance might be of significance in the development of muscular fatigue and pain.
The human trapezius muscle has an origin that is more extensive than that of any other body muscle; it has a complex macroscopic structure with fibers running in different directions. Histochemical analysis of multiple samples, obtained from different parts of the trapezius muscle from five males, showed marked differences in the distribution and the cross-sectional fiber area of the fiber types among different parts of the muscle as well as among individuals. As revealed by the mATPase activity, after different levels of alkaline and acidic preincubations, the lower third of the descending portion, the transverse, and the ascending portions of the muscle had a predominance of type I fibers (low mATPase activity at pH 9.4), whereas the most superior parts of pars descendens had a higher frequency of type II fibers (high mATPase activity at pH 9.4). The fibers of the most superior parts of the muscle were considerably smaller compared with those in all the other parts. In sections stained for NADH-TR, moth-eaten fibers were observed within parts of the descending portion. Their location and their larger fiber area, compared with that of ordinary type I fibers, may be related to frequent and/or continuous use of these fibers. In conclusion, the differences in fiber type composition between the different parts of the muscle probably reflect different functional demands on the trapezius muscle in various head, neck, and shoulder movements. We suggest that the interindividual differences in muscle fiber composition are due, at least in part, to genetic factors.
Primary fibromyalgia syndrome (PFS) is a form of nonarticular rheumatism characterized by muscular pain and stiffness, commonly located in the neck-, shoulder-, back-, and pelvic regions. The most common finding in patients with mandibular dysfunction (MD) is pain or tenderness of the masticatory muscles, but tender and painful neck and shoulder muscles are also often found in relation to jaw muscle affection. Complaints presented by patients suffering from musculoskeletal conditions may overlap one another. Indeed, there may be some common causative factors for these complaints. To test the hypothesis that some complaints by PFS patients could be explained by mandibular dysfunction, we have investigated the subjective symptoms and the clinical state of the stomatognathic system in eight patients suffering from PFS. According to the Helkimo anamnestic dysfunction index, six patients were classified as having severe signs of MD. The Helkimo clinical dysfunction index revealed severe or moderate dysfunction in all patients. Recurrent headaches was reported by half of the patients. In conclusion, the present study shows that PFS patients also may suffer from mandibular dysfunction. Thus, an examination of the function of the stomatognathic system would be an important part in the investigation to elucidate possible etiological factors behind the reported complaints by PFS patients. PFS may also be of etiological importance for mandibular dysfunction.
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An experiment was conducted in which 66 male subjects were given access to alcohol (20% vol.) and fruit juice to be mixed and tasted ad lib. A factorial design included social vs. solitary drinking conditions, laboratory vs. informal setting, and variable exposure to music. The amount of ethanol consumed (g/kg body weight) was used as an unobtrusive measure of preferred intake. The reciprocal relationship between mood and consumption was analyzed by LISREL. While euphoria has usually been perceived as a consequence of drinking, the only plausible fit to a LISREL model was obtained by assuming that the disposition to drink would be increased by positive mood changes occurring during the drinking session. An analogy between social drinking and adjunctive behaviour was supported, as alcohol consumption was directly affected by time-dependent environmental factors such as company and music. Since the presence of company also stimulated positive mood and alleviated boredom, consumption was precipitated by company indirectly as well as directly. These results emphasize the importance of direct as well as indirect environmental influences on spontaneous alcohol intake during social drinking.
In man, there are large differences in histochemical fibre-type composition, distribution and size between jaw and trunk muscles, probably related to the special functions of the human stomatognathic system. In the hedgehog, the influence of alkaline and acid pre-incubations on the reaction for myofibrillar ATPase was different from that in man, suggesting a different myosin structure; the fibre composition was different also. The masseter, the superficial portion of the temporal and the lateral pterygoid muscles all showed a homogeneous fibre type profile with almost 100 per cent alkali-stable fibres. In two animals, the deep temporal muscles showed an apparent heterogeneous fibre pattern with 81 per cent alkali-stable fibres, 4 per cent alkali-labile fibres and 15 per cent ATPase-intermediate fibres; in one animal 87 per cent alkali-stable fibres and 13 per cent ATPase-intermediate fibres. There was no difference in cross-sectional area between the three fibre types within each muscle, but the fibres of the lateral pterygoid were smaller than the alkali-stable and the alkali-labile fibres of the masseter and temporal muscles. The limb and trunk muscles showed reactions for myofibrillar ATPase similar to the jaw muscles, but had a heterogeneous fibre-type profile. There was no significant difference in cross-sectional fibre area between the jaw and the limb muscles. Thus the jaw and limb muscles of the hedgehog have similar fibre types and about equal fibre size.
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