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Biomedical subjects

R Lohse

Publications and source records attributed to R Lohse.

At least 19 recordsLinked to original sources

Evaluation and outcome of patients after polytrauma--can patients be recruited for long-term follow-up?

INTRODUCTION: There is limited information available about the long-term follow-up of polytrauma patients. In this study, the social and medical sequelae of trauma were reinvestigated at 10 years after the injury. METHODS: Patients were selected out of a population of polytraumatised patients treated at Hannover Medical School between 1973 and 1990. INCLUSION CRITERIA: multiple injuries treated at one institution, age between 3 and 60 years of age at the time of injury. Patients were recruited by gathering their residences from the charts. If patients had moved, up to three different registration offices were contacted by mail. The patient was contacted by mail (maximum three times) and by telephone. A patient was documented as lost to follow-up if none of these attempts was successful, or if he did not fulfil three subsequent appointments. All patients were examined by a physician, using a patient questionnaire and a standardized physical exam. RESULTS: Six hundred thirty-seven patients (67.8% of the potential enrollees) were evaluated on an outpatient basis by a trauma surgeon using a self-administered patient questionnaire and a standardized physical exam. In these, the average follow-up was 17.5 (range 10-28) years; the average Injury Severity Score (ISS) was 20.7 (range 4-54). Head injuries were the third most frequent injuries, but represented the most frequent cause of permanent disability (40%). The overall rehabilitation status graded by the patients was very good in 14.1%, good in 33.0%, satisfactory in 29.3%, sufficient in 16.0% and poor or insufficient in 7.5%. CONCLUSIONS: This study suggests that a high percentage of patients can be recruited for follow-up even after 10 years post trauma with the use of a meticulous reinvitation strategy. Head injuries accounted for the most frequent cause of disability, suggesting that more research should be provided to minimise the degree of injury and improve the outcome for head injured patients. Subjective grading of the outcome was better than expected in patients who had regained complete social rehabilitation.

Adolescent↗

The impact of injuries below the knee joint on the long-term functional outcome following polytrauma.

Previous studies have suggested that the lower-extremities are among the most frequently injured body regions in polytrauma patients and have a major impact on the functional recovery following polytrauma. In particular, injuries to the distal part of the lower-extremity appear to be associated with a poor functional outcome. Therefore, the goal of this study was to evaluate the impact of injuries below the knee joint on the long-term functional outcome following polytrauma. Three hundred eighty-nine polytrauma patients with associated lower-extremity fractures and a minimum follow-up of 10 years were included in this study. All patients were examined by a doctor, using a patient questionnaire and a standardised physical examination. Significantly, inferior outcomes were seen in patients with fractures below the knee joint as measured by the modified Karlström-Olerud score, Lysholm score, range of motion, weight bearing status, Hannover score for polytrauma outcome (HASPOC), SF-12, Tegner activity score, and inability to work (P < 0.05). Fractures below the knee joint have a significant impact on the functional recovery following polytrauma. We suggest that delayed treatment, thin soft tissue envelope below the knee joint, high-energy trauma, unfavorable blood supply, and complex fracture patterns contribute to these unfavorable outcomes.

Adult↗

[Incidence of metabolic disorders in patients with recurrent urinary calculi].

Of 117 formers of relapsing calcium oxalate calculi 75.2% showed a hyperuricaemia, 64.1% a hyperlipoproteinaemia, 19.7% a diabetes mellitus, 44.4% a hypertension, 11% a hyperuricuria (greater than 1.0 g/a day) and 7.5% a hypercalciuria. In 30 formers of relapsing uric acid calculi we could establish a hyperuricaemia in 93.3%, a hyperlipoproteinaemia in 76.7%, a diabetes mellitus in 36.7%, a hypertension in 80%, a hyperuricuria in 11% and a hypercalciuria in 3.8%. In comparison to formers of calcium oxalate calculi patients with uric acid calculi had a significantly higher body-weight. The results of our examinations make clear that in relapsing formation of urinary calculi frequently a complex disturbance of the metabolism is present which in every case must be established and treated.

Adult↗

[A case of malacoplakia of the prostate (author's transl)].

A case of malacoplakia of the prostate gland in a 75-year-old man is reported. This special type of granulomatous prostatitis was diagnosed by histological examination of biopsyn material. There were typical Michaelis-Gutmann corpusculates within the inflammation area. The structure of these inclusion bodies was investigated by electron microscopy. Characteristic concentric ring-shaped structures were seen as well as corpusculates which are composed of irregular cristalloid material. Some Michaelis-Gutmann bodies were found to contain short cell membrane-like structures. By histochemical investigation, both the cells possessing inclusion bodies as well as the Michaelis-Gutmann corpusculates themselves gave positive acid phosphatase reactions. The case is described because of the rarity of the malacoplakia of the prostate gland and with respect to the differential diagnosis of malignant prostate gland disease.

Aged↗

[Production of pullulan].

Optimum conditions for the production of pullulan by Pullularia pullulans were elaborated by examinating growth and production with different carbohydrates and mixtures of carbohydrates. With starch hydrolysates or mixtures of starch and simple sugars, p.e. glucose or saccharose, better results were achieved than with simple sugars alone or with starch. Condtions for optimum pullulan production are fast undisturbed growth, mediated by fast utilizable simple sugars like glucose followed by a substantial decreased growth rate in which production occurs, mediated by a sufficient supply of nutrite substances and a slow utilizable carbohydrate like starch.

Culture Media↗

[Medical check-up concerning cancer of the prostate. 1st report of experiences, results and documentation of findings].

It is reported on 1,790 medical check-ups concerning cancer of the prostate gland. We found 8 carcinomata = 4.47%. Apart from this 16 adenomata to be operated with adequate disturbances of the micturition were established. The documentation of the findings of medical check-ups by means of a reference on the basis of perforated cards is described and it is referred to the necessity of a systematic documentation of findings.

Adult↗