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Biomedical subjects

R Loredo

Publications and source records attributed to R Loredo.

11 recordsLinked to original sources

Imaging of osteochondral injuries.

Acute injuries can produce fragments consisting of cartilage alone or cartilage and underlying bone. A purely cartilaginous fragment creates no direct radiographic abnormalities, whereas one containing calcified cartilage and bone appears as a radiodensity. The advent and refinement of MR imaging have led to the detection of occult injuries of subchondral bone and cartilage that can escape identification on routine radiographic analysis. The available data appear to indicate a substantial role for MR imaging in the analysis of lesion stability in cases of osteochondritis dissecans; however, further studies are required to determine its advantages over other methods, in particular, arthroscopy. Indirect evidence of cartilage abnormality on MR images relates to the identification of fluid at the interface between the fragment and the parent bone. The MR imaging technique influences dramatically whether such fluid is identified. MR arthrography employing the intra-articular injection of gadolinium compounds can be advantageous in the delineation of the chondral surface and in the detection of intraarticular bodies. Optimally, MR imaging would allow direct analysis of the cartilage surface, and specific imaging sequences that are most suited to this analysis are still evolving.

Arthrography↗

Posteromedial corner of the knee: MR imaging with gross anatomic correlation.

OBJECTIVE: The objective of this study was to illustrate the magnetic resonance (MR) image appearance of the structures of the posteromedial "corner" of the knee with particular emphasis on the anatomy and differentiation between the medial collateral ligament and the posterior oblique ligament. DESIGN: Six cadaveric knee specimens underwent MR imaging, before and following instillation of intra-articular contrast material. The knees were sectioned in the axial, coronal, and coronal oblique planes and the gross morphology of the posteromedial corner and surrounding structures was studied and correlated with the MR images. PATIENTS: The human cadaveric specimens were from two female and four male patients (age at death, 72-86 years; average, 78 years). RESULTS AND CONCLUSIONS: The contrast-enhanced sequences and the coronal oblique images allowed for improved visualization of the structures.

Aged↗

Radiographic manifestations of rheumatic diseases affecting the foot and ankle.

Radiologic evaluation of the foot and ankle affected by rheumatic disease involves objective assessment of the radiologic changes that may be associated with a specific arthritis. Assessment of the severity of involvement and evaluation of progression or regression of the disease are important in the treatment regimen and ultimate clinical outcome of every patient.

Ankle Joint↗

Total hip arthroplasty in an adult with proximal femoral focal deficiency.

A 40-year-old woman with isolated unilateral proximal femoral focal deficiency presented with 2 years of gradually increasing left hip pain that interfered with her activities of daily living. A total hip arthroplasty was performed through a posterior approach. At 12 months, she had minimal discomfort about the hip, a markedly increased level of activity, and improved gait, and she required no ambulatory aids. This procedure is cautiously recommended for use in selected patients with proximal femoral focal deficiency.

Adult↗

Imaging experimental osteomyelitis using radiolabeled liposomes.

UNLABELLED: We evaluated radiolabeled liposomes (liposomes labeled both with 99mTc and 111In) for the early detection of osteomyelitis in an experimental model. METHODS: Liposomes, containing 5% polyethylene glycol-distearoyl phosphatidylethanolamine with encapsulated glutathione and deferoxamine, were prepared and labeled with 99mTc and 111In by a previously described method. Acute osteomyelitis was induced in male New Zealand rabbits by intramedullary injection of sodium-morrhuate and Staphylococcus aureus in the tibial bone marrow. Serial imaging studies, consisting of radiolabeled liposome imaging (2-4 mCi 99mTc and 75-125 microCi 111In), 99mTc-methylene diphosphonate (MDP) (3-5 mCi) and 67Ga-citrate (500 microCi), were performed starting at the third day after injection. Each radionuclide study was separated by at least 2 days. The animals also underwent radiography of the lower extremities. The animals were then killed and the infected tibia was excised for histopathology. RESULTS: For interpreting relative efficacy of individual radiopharmaceuticals, only animals showing positive histopathological findings (n = 9) were considered. Radiographs (Days 12, 13) were conclusive for osteomyelitis in only 3 rabbits. Radiolabeled liposome imaging (Days 4-6) showed positivity in 8 cases and was equivocal in 1. Though the lesion could be delineated as early as 8 hr postinjection in the 99MTc window, the best target-to-nontarget ratio (T/NT) of 1.86 +/- 0.19 was obtained at 48 hr in the 111In window. Three-phase 99mTc-MDP scan (Day 7) was positive in only 5 rabbits with 3 hr T/NT of 1.6 +/- 0.23. Galium-67-citrate images (Days 9-11) were positive in 8 cases and equivocal in 1, the mean 48 hr T/NT being 1.74 +/- 0.24. These results show liposomes are better than 99mTc-MDP for imaging bone infection. Given the early localization and better quality of the images, radiolabeled liposomes also exhibited advantages over 67Ga-citrate for detection of acute osteomyelitis.

Acute Disease↗

Glenoid labrum: MR imaging with histologic correlation.

PURPOSE: To document the histopathologic basis of altered intralabral and sublabral signal intensity on magnetic resonance (MR) images. MATERIALS AND METHODS: Ten fresh cadaveric shoulder specimens underwent transaxial MR imaging with T1-weighted, proton-density-weighted, and T2-weighted spin-echo; multiplanar gradient-recalled echo (MPGR); three-dimensional Fourier transform gradient-recalled echo (GRE); spoiled gradient-recalled echo (SPGR); and T1-weighted, fat-suppressed sequences before and after intraarticular injection of gadolinium. Shoulders were then frozen and transversely sectioned, and histologic analysis of the labrum was performed. RESULTS: Altered intralabral signal intensity correlated with fibrovascular tissue, mucoid or eosinophilic degeneration, calcification, ossification, synovial tissue, or combinations of these findings. A sublabral transitional band of intermediate signal intensity correlated with a transitional zone of fibrocartilage. CONCLUSION: There are several causes of altered intralabral signal intensity. A transitional fibrocartilaginous zone correlates with sublabral increased signal intensity. Intraarticular administration of gadolinium improves evaluation of the glenoid labrum.

Aged↗

Prospective evaluation of adrenal insufficiency in patients with adrenal metastasis.

Fifteen consecutive patients with metastatic carcinoma who demonstrated bilateral adrenal metastasis on abdominal computed tomography (CT) were evaluated by the cosyntropin challenge test. Primary sites of tumors included lung, ten; colon, two; gastric, one; ovarian, one; and unknown primary, one. Bilateral adrenal enlargement was defined as greater than 1 cm on CT scan. Adrenal insufficiency was defined as a failure to increase serum cortisol by at least 5 micrograms/100 ml to a minimum of 15 micrograms/100 ml at either 30 or 60 minutes postcosyntropin. No patient had previously been on corticosteroids. All patients were questioned and examined for symptoms/signs of adrenal insufficiency. Five patients (33%) were found to have adrenal insufficiency based on the cosyntropin test. Of the clinical parameters evaluated, all five patients had nausea, anorexia, and orthostatic hypotension. The clinical onset of adrenal insufficiency was insidious; no patient experienced acute adrenal crisis. We conclude that adrenal insufficiency is not a rare occurrence in patients with metastatic cancer and bilateral adrenal involvement on CT scan.

Adrenal Gland Neoplasms↗

Magnetic resonance imaging in pachydermoperiostosis.

Pachydermoperiostosis is a rare inherited disorder that is manifest clinically by digital clubbing, extremity enlargement, painful and swollen joints, hypertrophic skin changes, and periosteal bone formation. This report illustrates the skeletal findings that may be seen with long-standing disease as evaluated with conventional radiography and with magnetic resonance (MR) imaging, with emphasis on the MR appearance of periosteal reaction in this disorder. There are features that suggest pachydermoperiostosis may represent a generalized enthesopathy.

Adult↗

Pictorial essay. MRI of the glenoid labrum with gross anatomic correlation.

The objective of this pictorial essay is to illustrate the magnetic resonance image (MRI) appearance of the glenoid labrum and the perilabral structures with and without instillation of intraarticular contrast material. Ten cadaveric shoulder specimens underwent axial MRI using various MR pulse sequences. The shoulders then were transversely sectioned, and the gross morphology of the labrum and perilabral structures was evaluated and correlated with the MR images. The contrast-enhanced sequences allowed for improved anatomic visualization of the structures evaluated.

Aged↗

MRI of the common peroneal nerve: normal anatomy and evaluation of masses associated with nerve entrapment.

The objective of this pictorial essay is to illustrate the MR appearance of the common peroneal nerve and the appearance of masses that have been associated with peroneal nerve entrapment. Four human cadaveric knees underwent axial MRI utilizing a T1-weighted SE sequence. One knee was dissected by an orthopedic surgeon and three knees were transversely sectioned, and the gross morphology of the common peroneal nerve and the perineural structures was evaluated and correlated with the MR images.

Adolescent↗