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Biomedical subjects

R Ludewig

Publications and source records attributed to R Ludewig.

At least 19 recordsLinked to original sources
PubMed1992

[Possibilities and limits of medical graphology. Determination of current status and perspectives (I)].

As is generally known, the writing movement reacts in a sensitive manner to numerous diseases, medications, stimulants and environmental poisons, as well as to psychic and physical influences. This reaction can occur quite early in the process. Therefore, laboratory data and the physical examination can be supplemented by the handwriting. The graphological analysis is particularly helpful in the following ways: early diagnosis, documenting the course of the disease, evaluating treatment, psychological relationships as well as the problems of old age. This review, presented in three parts, intends to demonstrate to the physician simple and time-saving possibilities, as well as analytical methods, that are most likely to promise success. This needs to be done by a competent graphologist.-Prejudices against graphological methods and exaggerated expectations will be reduced if proper information is presented.

Diagnosis, Differential↗
PubMed1991

[The controversy regarding the cause of death of Wolfgang Amadeus Mozart (28 January 1756-5 May 1791)].

All since two hundred years closely contested hypotheses about the causes of Wolfgang Amadeus Mozart's death are to be verified and to be made credible by the same "original sources" in spite of considerable contrasts. In the present study it is tried to indicate the reasons for the multifariousness of the opinions and to represent Mozart's death as the consequence of a multifactorial process.

Austria↗
PubMed1990

[Possibilities and limitations of rapid radiologic detection of selected chemicals in acute poisoning of unknown origin].

Knowledge of the radiopacity of bromine-containing hypnotics and of halogenated hydrocarbons has led to numerous recommendations and speculations. Supported by own investigations the sensible application of a rapid radiological determination in the practice of clinical toxicology is discussed. This should always be carried out, if solvent residues, gastric contents or gastric lavage fluid are available, a ingestion is suspected, and the result of chemical analysis is not promptly obtainable. However, a hint at the group of halogenated hydrocarbons is only possible, if additional information about miscibility with water is accessible. Revealing the presence of radiopaque material in tablet or liquid form by radiologic studies of the abdomen may be very helpful for the rapid evaluation of symptomatology and first therapeutic consequences, but it does not allow any chemical identification of the poison.

Gastric Lavage↗
PubMed1989

[Etiologic and pathogenetic aspects of the demyelinating process in multiple sclerosis].

In our opinion there is no specific germ for multiple sclerosis. The pathogenic process is developed after a clinically "silent" period and results in a demyelinization process. Partially genetical aspects have to take into account for certain disease processes. Up to now both, the theory of infection as well as the neuroallergetic theory are of importance.

Adult↗
PubMed1987

Research approaches on the diagnosis of multiple sclerosis by CSF examination.

The diagnostic value of CSF oligoclonal IgG bands, intrathecal IgG synthesis, cytology and markers of myelin breakdown in the cerebro-spinal fluid were evaluated in multiple sclerosis. None of the various immunological alterations were unique to MS. The diagnosis depends therefore mainly on course and clinical symptoms, but can be supported by CSF analysis.

Cerebrospinal Fluid↗
PubMed1987

[Progress of research in the diagnosis of multiple sclerosis by study of the cerebrospinal fluid].

There are neither specific cell investigations nor immunological tests for the diagnosis of MS. Various immunological alterations occur in the course of the disease, but none is unique to MS. Accurate diagnosis remains confined to the clinical field. The diagnosis can be supported by CSF analysis. Laboratory examinations can help to determine the particular stage of the disease and provide clues to the etiology and pathogenesis. The appearance of abnormal CSF levels increases the certainty of the diagnosis.

Blood-Brain Barrier↗
PubMed1987

Non-steroidal anti-inflammatory drugs: how do they work?

Current dogma holds that non-steroidal anti-inflammatory drugs (NSAIDs) act by inhibition of the synthesis and release of prostaglandins. However, NSAIDs also inhibit the activation of neutrophils, which provoke inflammation by releasing products other than prostaglandins. We now report that NSAIDs (for example, indomethacin, piroxicam) inhibit activation of neutrophils by inflammatory stimuli such as C5-derived peptides and leukotriene B4 even when cyclooxygenase products generated in suspensions of stimulated neutrophils (prostaglandin E and thromboxanes) are present. Sodium salicylate (3mM) greatly inhibited aggregation of neutrophils but had no effect on aggregation of platelets or production of thromboxane induced by arachidonate. Sodium salicylate and other NSAIDs also inhibit calcium movements (45Ca uptake, changes in fluorescence of chlortetracycline and Quin-2). Aspirin, sodium salicylate, indomethacin, and piroxicam also enhanced the post-stimulation rise in intracellular cyclic AMP. NSAIDs therefore inhibit early steps in neutrophil enhance intracellular levels of cyclic AMP.

Adult↗
PubMed1987

[Clinical and pathophysiologic aspects of viral infections of the CNS].

The available defensive mechanisms are generally sufficient to protect the central nervous system (CNS) against the penetration of infectious particles. The blood-brain-barrier plays a decisive role in this process. The present paper represents the most important circumstances realizing that: 1. The macrophage-lymphocyte-system, 2. the "oligoclonal-CSF-IgG-reaction", and 3. the influence of psychological and physiological burdens on clinical-chemical or immunological parameters. It seems to be important to overcome the instability of the immunosystem and to reestablish the base-line.

Encephalitis↗