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Biomedical subjects

R Luque Mialdea

Publications and source records attributed to R Luque Mialdea.

At least 19 recordsLinked to original sources
PubMed2005

[Use of oral anticholinergic therapy in children under 1 years of age with high risk bladder].

THE AIM: To assess the effectiveness and safety of the treatment with oral anticholinergic agents (Oxybutin clorure) in patients under 1 year old, and who aree carriers of high risk bladder secondary to neurological illness as well as no neurological one. MATERIAL AND METHODS: Since 1989, we have indicated treatment with anticholinergic agents to 16 patients: 9 patients had neurogenic bladder secondary to: myelomeningocele (n=7) and sacrocoxigeal teratoma (n=2). Others 7 patients had non neurogenic bladder secondary to: posterior urethral valvulas (n=1), valvula-like syndrome (n=4), post-surgery of neonatal giant bladder diverticulum (n=1) and Prune-Belly syndrome (n=1). The urodinamic study was performed during the first six months of life, being "high risk bladder" defined according to the parameters of compliance vesical and pressure of leak at point (PER). Five of the patients showed neonatal cronic renal failure (CRF), who were treated by cutaneus temporary derivation. All patients at treatment with anticholinergic agents at a 0.2 mg/kg/day dose was established; other early adjunctive treatment prior to the closure of the urinary derivation in children with CRF(n=5); or as a part of the conservative treatment (n=3), alone or associate to intermittent bladder catheterization (IBC) (n=8). During the treatment with anticholinergic agents, the cardiac frequency was controlled by EKG registration in 6 patients, being the rest of the children clinicaly controled (skin colour, mouth dryness, cardiac frequency and intestinal function). RESULTS: In all the cases, the minimum duration of the treatment was one year, until the functional stabilization of the urinary tract. It is to underline the absence of secondary complications which would have caused the suspension or the reduction of the treatment at long term. Conventional studies of urologicals image and urodinamic studies, showed the stabilization of the urinary tract and also the preservation of kidney function and not only was demonstrated in those patients with oral anticholinergic agent as their unique treatment, but also in those patients who had previously been derivated. The previous vesical stabilization allowed the optimum result of subsequent corrective surgeries in five patients (ureteroneocystostomy and vesiscotomy clousure. In cases with previous derivation, the treatment with oral anticholinergic agents made easier vesicostomic clousure in the forth quarter of the first year old wih the maintenance of the vesical stability. CONCLUSIONS: The use of oral anticholinergic agents at a dose of 0.2 mg/kg/day, has resulted to be safe as well as effective in the treatment of high risk bladder in infancy those with less than one year of life. In those patients with serious dysplasia by reflux, it contributes to the preservation of kidney function, it makes easier the early desderivation and it also stabilizes in a functional way the bladder as a previous step to subsequent reconstructive surgeries.

Child↗
PubMed2005

[Retroperitoneoscopic nephrectomy: our experience in short-term hospital stay].

OBJECTIVE: To prove that the nephrectomy, in spite of being a major surgery, requires less than 48 hours stay hospital if it is performed by retro peritoneal approach. Consequently this procedure can be carry out in a short hospital stay. MATERIAL AND METHODS: From 1995, we have treat 40 patients by retroperitoneoscopic nephrectomy, 46 nephrectomies in total, being bilateral in 6 patients because of terminal renal failure (TRF), who do not take part in that study. The average age was 4.8 years range old (with a rank between 6 months and 13 years old), in relation with sex, male (n=16) and female (n=18). As for the side of the nephrectomy, it was the right in 20 cases and left in 14. Those pathologies, which indicated the nephrectomy because of kidney's functional annulations, were: obstructive hydronephrosis (n=2); obstructive megaureter (n=1); kidney destroyed by reflux (n=8); multicystic displasia (n=11); involution multicystic diyplasia (n=12). RESULTS: In all the cases, the nephrectomy was pure retroperitoneal approach. The average time of surgical duration was of 92 minutes (with a range between 60-240 minutes). It was reconversion in 1 case (4.5%) by peritoneal micro perforation (n=1). We underline absence of inherent complications to retroperitoneoscopy, intraoperative and postoperative procedures. As secondary complications to the access surgical procedure were 2 wall relaxations because of incisional injury and one serum collection of the first port site. The bleeding during the operative act was imperceptible, less than 20 cc. Drainages were not left in the operative bed. The average stay has been reduced to 27 hours, without being counted the 6 cases of TRF. In the last 18 cases the hospitality discharge was made in the first 24 h postoperative. The analgesic established by protocol was analgesic of infiltration of ports site with 1% bupivacaine and one dose of paracetamol/ibuprofen, given 12h after the intervention and repeated after hospitality discharge. Essumpcion of their day home-life and school- was earlier in 100% of cases. We underline the absence of secondary complications to pain (breathing) neither to immobilization. CONCLUSIONS: The retroperitoneoscopic nephectomy is a clearly established indication and of required fulfilment in paediatric age. It is the suitable surgical boarding to perform a nephrectomy because of its reliability, reproductibile and safety. Media hospital stayis lesser when the nephrectomy was performed by retro peritoneal approach than conventional surgery. Consequently this procedure can be carry out in a short hospital stay.

Adolescent↗
PubMed2003

[Non-coordinated micturition syndrome mimicking posterior urethral valves in a male neonate].

UNLABELLED: High-grade of vesicoureteral reflux (VUR) has been reported in association with prenatal diagnosis of abnormal bladder function in a male neonate with postpatally no anatomical urethral obstruction and bladder dysfunction. This study was designed to describe clinical presentation of this entity in male neonates, the urodynamic pattern, prognosis in terms of renal function and therapeutic management since birth, in our experience with four cases. MATERIALS AND METHODS: We reviewed the records of 4 male neonates diagnosed at birth of bilateral high-grade VUR (grade > or = 4) with prenatally diagnosed hydronephrosis; thus 8 refluxing renal units (RRU) were studied. All cases had renal failure at birth. In all cases dimercaptosuccinic acid (DMSA) renography was performed. All RRU had reflux nephropathy; 5 RRU had moderate impairment of renal function (20-40%). In 3 RUU was demonstrated by a severe decrease in renal function (10-20% in 2 RUU, and less than 10% in 1 RUU). Micturating cystouretrography (MCUG) excluded the presence of posterior urethral valves; however, in all cases a tightened bladder neck ("bladder neck impression") was present. Endoscopy was performed in one baby excluding posterior urethral valves. Follow up ranged from 2 to 5 years (mean 3.5). RESULTS: In all 4 cases underwent transient urinary diversion during their first month of life. Urodynamic study revealed a high-risk bladder with low compliance, a reduced functional bladder capacity and a high residual urine volume in all cases. All the patients was placed on antibiotic prophylaxis and oral oxybutinin chloride. Three patients underwent bilateral Cohen ureteral reimplantation. The other boy underwent left nephrectomy, right Politano ureteral reimplantation and ureterocystoplasty. In the 7 RRU postoperative MCUG revealed cessation of reflux. Currently therapy includes antibiotic prophylaxis in 4, oral oxybutinin in 4 and intermittent catheterisation in 2 patients. 3 patients have normal renal function. The other boy underwent re-diversion because of renal failure. CONCLUSIONS: Fetal severe bilateral reflux nephropathy is a clinical entity almost exclusively in male neonate mimicking hyper-pressure syndrome due to urethral obstruction, in terms of evolution (to chronification and renal failure) and treatment (that requires primordial management of bladder dysfunction). Absence of anatomical urethral obstruction and urodynamic pattern suggest functional obstruction of bladder neck-periurethral sphincter complex in fetal life as a cause for this syndrome. For this reason we consider it as a clinical presentation of fetal non-coordinated voiding in male or "posterior urethral valves like syndrome".

Diagnosis, Differential↗
PubMed2001

[Predictive value of stress leak bladder pressure in urinary incontinence in children].

UNLABELLED: The stress leak point pressure is the lowest bladder pressure at which leakage occurs during increases in intra-abdominal pressure. Our goal was the study of the stress leak point pressure in children to determine if it is a useful method of evaluation of incontinence and how it can be applied to pediatric clinical practice. We prospectively studied 68 consecutive incontinent children: Group 1 included 50 children neurologically normal. Group 2 included 18 children with myelodysplasia. RESULTS: 1) No correlation was found between stress leak point pressure and leak point pressure values. 2) The difference between the volumes at which the stress and rest leak were obtained was not statistically significant. 3) Study of stress leak point pressure: Group 1; Leakage during stress only occurs in 16%. Stress leak point pressure was greater than 100 cm of H2O in these children. Group 2; Leakage during stress occurs in all children (positive test in 100%). Stress leak point pressure was less than 100 cm of H2O, indicating intrinsic sphincter deficiency. These results suggest the stress leak point pressure is a diagnostic test that provide information about the function of proximal urethra and bladder neck in pediatric population, and an useful tool to despite of intrinsic sphincter deficiency.

Adolescent↗
PubMed2000

First Spanish Trauma Registry: analysis of 1500 cases.

OBJECTIVES: To develop the first Spanish Pediatric Trauma Registry to collect and evaluate infomation concerning aspects of injuries in our pediatric population. METHODS: From January 1995 to August 1998, 35,946 children younger than 16 years were treated in our hospital for acute injury: 1500 were admitted and included in our database. Our file registry consists of 108 data points including: patient identification, type, place and mechanism of injury, pre-hospital care, transport, assessment on admission, severity scores, diagnostic studies, injuries, treatment morbidity and mortality. RESULTS: Accidents were more frequent in males (68%) than in females. The predominant age group was 12-15 years of age (34%). Accidents were more frequent in the street (35.1%) than at home (18.9%) or school (13%). Falls and traffic-related accidents were the leading cause of injury (39% and 21.2%, respectively). Two hundred and thirty-five (15.7%) had a Pediatric Trauma Score < or = 8. Fifty of these sustained multiple trauma (33%) (Injury Severity Score > or = 15). Musculoskeletal and head trauma were the most frequent injuries (48.5% and 42.0%, respectively). Surgical or orthopedic procedures were performed in 906 patients (56.5%). The average length of stay was 4.5 days (range 1-93 days). Functional impairment in children older than 4 years of age was found in 413 children (33.3%). We encountered 7 deaths in the 1500 patients, or an overall mortality of 0.5%. These 7 deaths were only seen in the I.S.S. > or = 15 group (50 patients) with 14% mortality. CONCLUSIONS: The goals of this Registry are to establish the epidemiology of our injured pediatric population, to review patient care, to develop prevention programs and to compare results with other centers so that potential deficiencies can be corrected.

Adolescent↗
PubMed1999

[Indications from the laparoscopic approach in pediatric urological surgery: our experience in 49 patients].

OBJECTIVES: To analyse the diagnostic and therapeutic potential of video-assisted laparoscopy in the urology paediatric pathology. We had analysed its indications and results, to measure in disminution of morbidity and hospital stay. PATIENTS AND METHODS: We are treated in our section of Paediatric Urology 49 patients during the period of June 1995 and December 1998, performing 51 laparoscopics procedures. The mean age was 8 years (2-16 years ago). The laparoscopic indications were diagnostic in 33 patients: intra-abdominal testes (n = 16), renal biopsy (n = 17), and terapeuthics in 16 patients (17 laparoscopics procedures): varicoceltomy (n = 7), orchiectomy (n = 1), closure peritoneal-vaginal duct (n = 2), retroperitoneal nephrectomy (n = 6), marsupilazation and omentoplastic in giant lymphocel renal post-transplantation (n = 2). RESULTS: The laparoscopic approach were effective in 100% of diagnostic procedures and 93.4% of therapeuticm procedures. Conversion in 2 cases were necessary to make renal biopsy (n = 1). We hadn't have postoperatives complications and the indices of intraoperative morbidity was of 2.4%. The mean hospital stay was 1.4 days. CONCLUSIONS: We believe that exist indications clinically stabilised of laparoscopic approach--diagnostic and therapeutic--in paediatric urology. There are others indications that its are consider anecdotal in the present but in immediately future these indications will be valid.

Adolescent↗
PubMed1999

[Bladder with non-coordinated voiding: urodynamics and clinical correlations].

25 children (female) with urodynamically proven non-coordinated voiding were followed prospectively. The objective was to study the changes of urodynamic pattern and its clinical correlation after voiding reeducation and pharmacological treatment. All patients presented with urinary tract infections and voiding disfunction symptoms. 5 children had vesicoureteral reflux on voiding cystography and 10 patients had established scars on DMSA scan at initial presentation. Urodynamic study showed constriction of the urinary sphincter during voiding and increase of post-voiding residual urine volume in all children, with bladder instability 20 (80%). Treatment consisted of voiding reeducation, anticholinergics, antibiotic prophylaxis and muscle relaxants. The mean of follow-up was 22 months. Clinical remission occurred prior to urodynamic remission in all girls. Clinical recurrence was observed in 2 girls after cessation of treatment prior to normalization of urodynamic pattern. Non-coordinated voiding should be diagnosed and treated at pediatric age to avoid its possible progression to renal failure in other period of life.

Adolescent↗
PubMed1998

[Pediatric trauma registry: analysis of 1200 cases].

OBJECTIVES: We developed the first Spanish Pediatric Trauma Registry in order to collect and evaluate information concerning aspects of injuries in our pediatric population. METHODS: From January'95 to September'97, 28,713 children younger than 16 years were treated in our Hospital for acute injury: 1,200 were admitted and included in our database. Our file-registry consists of 108 data points including: patient identification, type, place and mechanism of injury, pre-hospital care, transport, assessment on admission, severity scores, diagnostic studies, injuries, treatments and morbidity-mortality. RESULTS: Accidents were more frequent in males (69%) than in females. The age-group predominantly was 12-15 years old (34%). Accidents were more frequent in the street (35.3%) than at home (18.7%) or school (14%). Falls and traffic-related accidents were the leading cause of injury (38 and 21.1%, respectively). The 16.7% of cases had Pediatric Trauma Score < or = 8 (n = 201). The 3.6% of this sustained multiple trauma (43 cases with Injury Severity Score > or = 15). Musculoskeletal and head trauma was the most frequent (62 and 42.3%, respectively). Surgical or orthopedic procedures were performed in 678 patients (56.5%). Average length of stay were 4.8 days (range 1-93 days), and functional impairments at discharge were found in 33.9% of patients older than 3 years (n = 338). Mortality rate in our series was 0.5% (n = 6), and 13.9% in children with ISS > or = 15. CONCLUSIONS: The utility of this Registry is to know the epidemiology of our injured pediatric population, to review patient care, to develop prevention programs and to compare results with other centers so potential deficiencies can be identified and corrected.

Adolescent↗
PubMed1997

[Retroperitoneal laparoscopic nephrectomy in children].

We present two cases of obstructive uropathy nefrectomy through a retroperitoneal approach was performed. Renal differential function by means of a 2,3 dimercapto-succinic acid renal scan showed less than 10% on the ipsilateral kidney to the diagnosis pathology. The size of the kidneys meant no hindrance during its nefrectomy. Morcellation within the organ bag was required for its removal without needing to broaden the 10 mm port opening. The patients were discharged home 48 hours after surgery and they returned to school within the first postoperative week.

Adolescent↗
PubMed1997

[Results of the conservative treatment of severe renal trauma in childhood].

Surgical treatment of severe renal trauma usually ends in loss of high percentage of kidneys. In consequence of this, in the last decade several authors prefer a conservative management of kidneys severely injured. There include stabilization in Intensive Care Unit, with the goal of preservation the most possible functioning renal tissue. The purpose of this paper is to present the results of conservative management of severe renal trauma in our Center in the last five years. We conclude that this type of management is accurate and effective.

Adolescent↗
PubMed1997

[Epidemiologic study of injuries in childhood: the first pediatric trauma registry].

OBJECTIVE: In order to collect and evaluate information concerning aspects of injuries in our pediatric population, we developed the first Spanish Pediatric Trauma Registry. PATIENTS AND METHODS: During 1995, 11,307 patients were seen at our hospital for acute injuries: 521 were admitted to the hospital and are included in our database. Each patient's protocol consists of 103 data points including: patient identification, type, place and mechanism of injury, prehospital care, transport, assessment on admission, severity scores, diagnostic studies, injuries, treatment and morbidity-mortality. RESULTS: We found that accidents were more frequent in males (69) than in females. The predominant age group was 12-15 years (36%). Falls were the leading cause of injury (37%). A pediatric trauma score of 8 or less was seen in 13.4% of the cases. Twenty-nine patients were hospitalized in the Intensive Care Unit and 214 needed some surgical treatment. CONCLUSIONS: The utility of this registry is: 1) The knowledge of the epidemiology of our pediatric population. 2) To know and correct prehospital care deficiencies. 3) To improve hospital assistance and to recognize early prognosis factors.

Adolescent↗
PubMed1996

[Multicystic renal dysplasia: changes in the contralateral urinary tract].

We have treated seven children with multicystic dysplastic kidney during the last 15 years. Three of then presented contralateral upper urinary tract anomalies. Four cases were diagnosed during prenatal period and three during the first term of life. We did analytic kidney function evaluation, ultrasound examination, voiding cystourethrography, radionuclide scan, gammagraphy, excretory urography and urinary cultures in all cases. We have found a vesicoureteral reflux with a bifid pelvis associated in the same child and two other cases with nonobstructive hydronephrosis. The child with vesicoureteral reflux presented also ipsilateral anomalies like a bladder diverticulum and an incomplete urethral duplication. One child with hydronephrosis opposite to the multicystic dysplastic kidney, also presented a bowel malrotation and a congenital cardiopathy, as extra-urologic associated anomalies.

Female↗
PubMed1996

[Therapeutic attitude in patients with multicystic dysplastic kidneys].

We presented seven multicystic dysplastic kidney cases treated in our Hospital during the last 15 years. Four children were diagnosed prenatally and three during the first term of life. Five were girls and two boys. We found three contralateral upper urinary tract anomalies. We did five nephrectomies. In two cases because compressive abdominal mass during the neonatal period, in two cases during the first year of life because symptomatic urinary tract infections and one case at the age of 13 months with persistent multicystic dysplastic kidney followed by ultrasound. Two cases were not operated. In one patient with partial regression of the multicystic kidney the family refused operation. We have lost follow-up in the last patient.

Cysts↗
PubMed1995

Cocket syndrome: thrombotic-septic disease post-appendicectomy complication.

The incidence of complications following treatment of acute appendicitis in childhood is lower than 5%, while thromboembolic disease at that age is exceptional. The case of a 13-year-old male who was operated on in our pediatric surgery department for acute gangrenous appendicitis is presented. His condition improved until the sixth day after the operation when he suffered thrombosis in both the left iliac vein and the inferior cava. Ultrasonography, plethysmography and computer tomography (CT) studies were carried out and a diagnosis of venous thrombosis was made with an underlying congenital vascular malformation where the iliac vein was compressed by the overlying iliac artery; known as the Cocket syndrome. The etiology diagnosis and treatment of this rare disease in childhood is reviewed.

Adolescent↗
PubMed1995

Microsurgical treatment of varicocele in adolescents.

Between March 1990 and November 1992, 22 adolescents with varicocele, 13 unilateral left and 4 bilateral, are presented. They were all treated with microsurgical techniques by shunting the venous drainage by means of a spermatic inferior epigastric end-to-side anastomosis. The results achieved have been optimum with the clinical disappearance of varicose veins in 100% of the cases and the elimination of the spontaneous reflux of the interna spermatic vein in 100% of the patients shown by echodoppler. This technique enables the establishment of an immediate and physiological testicular venous drainage fundamental for testicular growth and development.

Adolescent↗
PubMed1995

[Indications for urodynamic studies in childhood: our experience with 214 surgical patients].

Between 1983 and 1994, 515 pediatric patients with medical and/or surgical problems underwent urodynamic evaluation. We present the urodynamic findings of 214 children with surgical pathology: 73 cases with vesicoureteral reflux, 26 with urethral stricture, 11 with posterior urethral valves and 104 cases with lipo- and myelomeningocele. We found a high incidence of urodynamic abnormalities associated to these pathologies: 46.5 in patients with vesicoureteral reflux, 88.4% in urethral strictures, 54.4% in posterior urethral valves and 100% in patients with spina bifida. In our opinion, the urodynamic assessment has a contributory role in the indication for corrective surgery; because the knowledge of the vesicourethral complex state will help to stabilize it through a correct individualized medical treatment before surgical treatment, delaying or even avoiding surgery in some cases.

Age Factors↗