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Biomedical subjects

R M Bikbulatov

Publications and source records attributed to R M Bikbulatov.

At least 19 recordsLinked to original sources
PubMed1980

[Immunoglobulins A, M, G, and E in children with acute viral respiratory diseases and the croup syndrome].

Children with croup appearing in the presence of acute viral respiratory diseases (AVRD) show an increase in the IgM content in their blood sera during the first days of the disease followed by a decrease, and an increase in the IgG and IgE levels during the convalescence period. No essential shifts in the content of IgA have been observed. The total content of the immunoglobulins in children with croup, was lowered as compared to that in AVPD patients having no croup which is, probably, of a certain pathogenic importance. The increased content of IgE revealed in the blood sera of children with croup indicates the presence of an allergic component in this disease.

Acute Disease↗
PubMedDate not supplied

[Rapid diagnosis of ophthalmic herpes].

The developed method for rapid diagnosis of ophthalmic herpes is based on quantitative estimation of the results of immunofluorescent studies of the cells in scrapings off the eye conjunctiva. A total of 213 patients were examined with the use of this method; herpes simplex virus antigen was detected in 56.5%, but only in 23.5% of the examinees the antigen levels surpassed 10 and 100-fold the levels of basal virus carriership. Parallel clinical laboratory diagnostic investigations have shown that the second and third stages of the virus antigen accumulation in the conjunctival cells correlated with the severity of the clinical symptoms.

Antigens, Viral↗
PubMedDate not supplied

[The use of the ultrasonic spraying of interferon and larifan solutions for treating acute herpetic stomatitis in children].

Ultrasonic spraying of drug solutions was used in the treatment of 100 children suffering from acute herpetic stomatitis and its efficacy compared to that of common spraying of drugs in 100 children of the reference group. The results evidence that ultrasonic spraying accelerates cure by 2-3 days and is drug-saving. Interferon was found to be the most effective drug for acute herpetic stomatitis; larifan, used for the first time in the treatment of this condition, was inferior to it, though still effective enough.

Acute Disease↗
PubMedDate not supplied

[Antiviral activity of experimental combination of 5-iodo-2-deoxyuridine with 6-azauridine and its effectiveness in the treatment of herpetic infection with lesions of the skin and mucous membranes].

The use of the combination of 5-iodo-2-dioxyuridine (IUDR) and 6-azauridine drugs differing in their mechanisms of action in an experimental herpetic infection demonstrated its definite antiviral activity, not only not inferior to the effect of each of the drugs alone, but also remaining sufficiently high when the concentration of IUDR was decreased 2-fold. In clinical trials in relapsing genital herpes all the drugs under study showed statistically significant therapeutic activity. The combined use of the drugs exerted a certain synergistic effect.

Adult↗
PubMedDate not supplied

[The treatment of herpetic stomatitis in children with ointments containing alpha- and gamma-interferons].

Clinical efficacies of ointments containing alpha- and gamma-interferon and characterized by antiviral activity (2.0 x 10(4) IU) were studied. Antiviral effect of these ointments used in the treatment of 168 children suffering from herpetic stomatitis was assessed from the clinical and immunologic viewpoints. Measurements of secretory IgG carried out over the course of therapy evidenced positive changes in local immunity.

Acute Disease↗
PubMedDate not supplied

[Herpes simplex in acute viral respiratory diseases].

Herpes in main viral acute respiratory diseases (ARD) in adults (influenza, parainfluenza, adenovirus and mixed infections) was studied by different laboratory methods of diagnosis. It was found that in 44.5% viral ARD were accompanied by herpes in the clinically overt or latent form. Herpes was detected with varying frequencies depending on the nosological forms of ARD as well as on the nature of the infection: more frequently in monoinfections than in mixed infections.

Acute Disease↗