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Biomedical subjects

R M Cayton

Publications and source records attributed to R M Cayton.

44 records · Page 3Linked to original sources
PubMed1979

Triamcinolone in corticosteroid-resistant asthma.

In an uncontrolled study 38 patients with chronic asthma were treated for up to 4.5 years (mean 2.9) with depot injections of triamcinolone acetonide. About half had proved difficult to control on large doses of corticosteroid tablets. Three-quarters were helped and the incidence of hospital admission amongst them was reduced. Side effects were tolerable and adrenal function was only moderately depressed. Spirometry showed continuing improvement up to three years after starting triamcinolone. Whether similar improvement could have been achieved by a different dosage regimen of corticosteroid tablets or whether it might have ocurred spontaneously was not tested. A controlled trial seems warranted.

Adult↗
PubMed1978

A comparison of salbutamol given by pressure-packed aerosol or nebulization via IPPB in acute asthma.

Salbutamol was given by pressure-packed aerosol or nebulizer via IPPB to patients with acute asthma to compare the effectiveness of these methods of inhalation. The results show that both methods produce significant bronchodilatation even in patients admitted with moderately severe asthma (FEV1 about 38% predicted) but a slightly greater improvement may be achieved by IPPB nebulization. Our findings indicate that supervised inhalation of a pressure-packed aerosol of salbutamol may be useful for the initial treatment of asthmatic attacks but confirm the marginal advantage of IPPB nebulization, which should be reserved for patients unable to inhale from a pressure-packed aerosol or failing to respond to its treatment.

Acute Disease↗
PubMed1977

Lignocaine aerosol and persistent cough.

Four patients with intractable cough improved for periods of between one and six weeks after treatment with 400 mg of lignocaine by aerosol spray. Suprisingly the lignocaine increased airways resistance in some of them. It is suggested that the excessive cough is due to excessive sensitivity of tracheal cough or irritant receptors, secondary to mucosal damage. The dangers of lignocaine inhalation are referred to.

Adult↗