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Biomedical subjects

R M FRIEDMAN

Publications and source records attributed to R M FRIEDMAN.

At least 19 recordsLinked to original sources
PubMed1964

POSSIBLE ROLE OF INTERFERON IN DETERMINING THE ONCOGENIC EFFECT OF POLYOMA VIRUS VARIANTS.

1. Infection of newborn C(3)Hf/Bi mice with both the highly oncogenic S variant and the poorly oncogenic M variant of polyoma virus caused significantly fewer tumors than infection with the S variant alone 2. Infection of newborn C(3)Hf/Bi mice at birth with either M or S variant caused resistance to infection with a heterologous agent, encephalomyocarditis virus, but the M variant caused a somewhat greater degree of resistance. 3. Extracts of tissues of animals infected at birth with the M variant had measurable levels of interferon, reaching a peak on the 5th day after infection with the virus. Extracts of animals infected with the S variant showed no such activity. 4. The growth curves of the two variants in newborn C(3)Hf/Bi mice showed that the S variant grew to a 1000-fold greater titer than did the M variant at 5 days after infection. Samples tested at 10 days showed a 10-fold difference. 5. These findings suggested that the difference between the variants in oncogenic potential might have been due to the greater interferon production induced by infection with the M variant than by infection with the S variant.

Animals↗
PubMed1962

The role of antibody, delayed hypersensitivity, and interferon production in recovery of guinea pigs from primary infection with vaccinia virus.

In guinea pigs, methotrexate and x-radiation have been employed to block the development of delayed hypersensitivity and of antibody to vaccinia virus during experimental infection. Animals whose specific responses were blocked by x-radiation and methotrexate recovered from vaccinia virus infection as rapidly as non-treated control animals suggesting that these responses were not essential in recovery of the infected animals. A virus-inhibiting substance with the properties of interferon was present in skin of untreated and methotrexate- and x-radiation-treated animals infected with vaccinia virus.

Animals↗