Interaction of a series of beta-adrenergic blocking drugs with rat hepatic microsomal monooxygenase.
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Adrenergic beta-Antagonists↗
Biomedical subjects
R M Facino
Publications and source records attributed to R M Facino.
Iopronic acid interaction with hepatic microsomal cytochrome P-450: relationship between chemical structure and binding.
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Animals↗
In vitro binding and metabolism of iopronic acid by rat liver microsomes.
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Aerobiosis↗
Radiopaque contrast media. XXXIX - Metabolism of iopronic acid by rat liver microsomes: characterization and identification of the metabolites.
The metabolism of iopronic acid, 2(2[(3-acetamido-2,4,6-triiodophenoxy)ethoxy]methyl)butyric acid, was studied in vitro using rat liver microsomes as enzyme source. By means of solvent extraction, T.L.C., H.P.L.C. and mass spectrometry, the hydroxyethyl (3-acetamido-2,4,6-triiodophenyl) ether and the 3-acetamido-2,4,6-triiodophenoxyacetic acid have been identified as the metabolities of the parent drug. No deiodinated metabolites were found. The probable mechanism of the in vitro formation of the metabolites is discussed.
Animals↗
Analysis of flavonoids by MECC with ultraviolet diode array detection.
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Chromatography, High Pressure Liquid↗