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Biomedical subjects

R M Fawdry

Publications and source records attributed to R M Fawdry.

6 recordsLinked to original sources
PubMed1989

Can quantitative renography predict the outcome of treatment of atherosclerotic renal artery stenosis?

The accuracy of quantitative gamma camera renography in predicting outcome of treatment was assessed in 31 patients with atherosclerotic renal artery stenosis. Glomerular filtration rate, renal perfusion, relative renal function, and mean parenchymal transit time were calculated before and after treatment (renal artery angioplasty or vascular surgery). Patients were also assessed during the follow-up period of up to 6 years. On the pre-treatment study, nine patients did not have prolongation of parenchymal transit time in the kidney on the side of the renal artery stenosis. Despite technically successful angioplasties, none of these patients showed a significant reduction in blood pressure or improvement in renal function. Twenty-two patients had prolongation of parenchymal transit time in the affected kidney. Three suffered complications of treatment, and the remaining 19 showed improvement in blood pressure control, reduction in parenchymal transit time, and improvement in relative renal function. Quantitative renography accurately predicted those patients who improved following intervention for atherosclerotic renal artery stenosis. On progress evaluation, patients with recurrent stenoses were easily identified.

Adult↗
PubMed1987

Three-hour volume of distribution method: an accurate simplified method of glomerular filtration rate measurement.

Eight hundred studies of glomerular filtration rate (GFR) measurements were performed by the standard slope-intercept method using [99mTc]DTPA and results were compared with a simultaneous measurement of the 3-hr tracer volume of distribution. A wide range of human renal function was studied and a nonlinear relationship between GFR and the volume of distribution resulted with an excellent correlation (r = 0.989). Agreement between the two measured parameters was not constant for all levels of renal function with the greatest accuracy being found for GFR = 60 to 100 ml/min.

Blood Volume↗
PubMed1985

Comparative assessment of techniques for estimation of glomerular filtration rate with 99mTc-DTPA.

The relative accuracy of five simplified methods of measuring glomerular filtration rate was prospectively assessed using 99mTc-DTPA. The slope of the biological clearance curve, the 3-h volume of dilution and three renal tracer uptake methods (Piepsz, Gates and Nielsen) were concurrently compared with a multiple blood sampling reference method. The volume of dilution method from a single blood sample was markedly superior to the other four simplified methods which all had a similar degree of accuracy.

Glomerular Filtration Rate↗
PubMed1985

Kidney depth measurement and its influence on quantitation of function from gamma camera renography.

Both total and relative renal function assessed from gamma camera renography are influenced by the depths of the kidneys in the body. Despite the ease with which renal depths may be measured (by ultrasound or nuclear medicine lateral scans), when calculating the total uptake function it is common practice to estimate the renal depth from the patient's weight-to-height ratio. Furthermore, it is often assumed that there is no significant effect on relative function measurements due to different depths of right and left kidneys. Our data, from 150 consecutive patients, does not support this assumption or the use of calculated depth estimates and highlights the need for accurate kidney depth measurement.

Adolescent↗