Biomedical subjects

R M Guinn

Publications and source records attributed to R M Guinn.

3 recordsLinked to original sources

PubMed1997

The outpatient hospital: a hospital without beds.

A radical reordering of the hospital building looms on the horizon. By the advent of the new millennium just a few years away, the outpatient hospital--a hospital without beds--will be the new healthcare model. The outpatient premise is that a wellness system is fundamentally different from a medical care system. The patient is no longer forced to distinguish between his ongoing health maintenance needs and his intermittent medical intervention needs. The barrier between the public health system and the acute care system disintegrates, and the two merge into one entity. Thus, hospitals evolve into outpatient wellness centers where the building's physical structure is a single entity in terms of service points.

Architectural Accessibility↗

PubMed1995

Synthesis and characterization of polyamides containing unnatural amino acids.

We describe the synthesis of several polyamides that retain the secondary structure of proteins and contain derivatizable side chains. The derivatizable side chain allows for further reaction of the polymer chain (e.g., chain cross-linking or addition of pendant groups). Polymers of alpha-amino acids containing a terminal unsaturated bond on the side chain have been synthesized. Poly-L-pentenyl glycine, poly-L-propargyl glycine, and poly-L-allyl glycine were synthesized chemically via Leuchs' anhydrides and enzymatically using subtilisin Carlsberg. Poly-L-propargyl glycine and poly-D,L-allyl glycine folded into the beta-sheet configuration whereas poly-L-pentenyl glycine assumed a helical conformation. The secondary structure of poly-L-allyl glycine and poly-D,L-pentenylglycine could not be determined conclusively. Comparison of properties between the polymers obtained chemically and enzymatically is provided.

Amino Acids↗

PubMed1993

Operational restructuring for patient focused care: the facility implications.

In the typical hospital, customer service lags behind clinical care. In spite of the promised efficiencies of quality control/quality assurance, costs have continued to soar, whilst the concept of patient focused care has been overlooked. More than 50% of costs are accounted for at 'operational level', due to historical trends towards centralization of ancillary services. Operational restructuring to emphasize 'patient focused' delivery of care implies a number of facility changes which are described below.

Architecture↗