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Biomedical subjects

R M Linggood

Publications and source records attributed to R M Linggood.

42 records · Page 3Linked to original sources
PubMed1980

The management of pineal area tumors: a recent reappraisal.

This study concerns our experience with 22 pineal area tumors from 1972 through 1977. Eleven identified tumors included: three gliomas, three pineoblastomas, two endodermal sinus tumors, one germinoma, one epidermoid, and one metastasis. Three others were presumptively germinomas. Twelve cases were treated by means of radiation and shunting if necessary. Eight patients had pineoblastomas and 2, endodermal sinus tumors. Death occurred in spite of radiologic evidence of radiation response. Cerebrospinal fluid (CSF) cytology was positive in 2 of 7 cases involving potentially disseminating tumors and negative in 2 cases involving spinal metastases. We conclude that radiation response and CSF cytology are insufficient to determine optimum treatment. Direct operations, which were not associated with mortality or serious morbidity were most useful for providing a tissue diagnosis.

Adolescent↗
PubMed1980

Management of glioma of the optic nerve and/or chiasm: an analysis of 20 cases.

The records of 20 patients with biopsy-proven glioma of the optic nerve and chiasm are reviewed. Symptoms and physical findings on admission are reported. Patients were classified, according to the operative findings, into disease limited to the optic nerve and a more extensive disease group. Surgical procedures, operative complications, irradiation technique, and outcome are analyzed. Patients with disease limited to the optic nerve may be adequately managed by resection alone. In the more extensive lesions, high morbidity is associated with resection; therefore, biopsy and irradiation offer the best alternatives for this group of patients.

Adolescent↗
PubMed1980

Management of intramedullary spinal cord tumors.

From January 1962 to May 1979, 23 patients with biopsy-proved intramedullary spinal cord tumors were treated initially with total resection, subtotal resection, irradiation, or subtotal resection and irradiation. Local control was achieved in 1/2 patients after total resection, 1/3 after subtotal resection, 8/9 after subtotal resection and radiation therapy, and 5/8 after radiation therapy alone. The patients with ependymomas exhibited a radiation dose-response relationship; of eight patients followed five or more years postirradiation, local control was achieved in 2/3 with time dose fraction (TDF) less than 55, 2/3 with TDF 55-65, and 2/2 with TDF greater than 65. The actuarial 5- and 10-year survival rates were 58% and 23% for astrocytoma, and 100% and 73% for patients with ependymoma, respectively. Neurological deficits improved or became totally normal after initial irradiation. Patterns of failure, management of recurrences, and radiotherapeutic techniques and dose recommendations are discussed.

Adolescent↗
PubMed1980

Clinical experience with proton beam radiation therapy.

Our experience with modulated energy proton beams in the definitive treatment of cancer patients indicates that, for the patients accepted, treatment volumes have been smaller and total doses higher than would have obtained for photon techniques alone used in our institution. The reactions of normal tissue have, with very few exceptions, been readily acceptable. The higher radiation doses employed should yield higher tumor control frequencies. Clearly, we cannot assess the efficacy of this modality because of the small number of patients followed for short periods. However, the results are judged by use to warrant intensive evaluation of this modality.

Child↗
PubMed1976

Radiation therapy and Corynebacterium parvum in the treatment of murine tumors.

The relative effectiveness of local irradiation alone or combined with Corynebacterium parvum (C parvum) treatment has been investigated employing four tumors: a mammary carcinoma (MCa) (nonimmunogenic), a fibrosarcoma (moderately strongly immunogenic), and two squamous cell carcinomas (SCC-2 being weakly and SCC-4 being very weakly or nonimmunogenic). C parvum treatment was started when the isotransplanted tumor growing in the mouse leg was 5 mm in diameter and the local irradiation was administered to 8-mm diameter tumor. Effect of the combined treatment was barely evident with the MCa but strongly present in FSa; up to 60% of mice were cured of FSa by C parvum alone and the response to low radiation dose, e.g., 200 rads, was highly increased. For SCC-2 the TCD50 was approximately 7000 rads and 3000 rads in control and test mice, respectively. Comparable values for SCC-4 were 7700 and approximately 5500 rads. Importantly, for SCC-4 there was a large and highly significant reduction in the proportion of mice that died of metastases to lung but were free of evident tumor at the primary site.

Animals↗