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Biomedical subjects

R M Maskell

Publications and source records attributed to R M Maskell.

8 recordsLinked to original sources
PubMed1990

Bacteriological state of the urine in symptom-free adult males.

Mid-stream urine specimens from 120 symptom-free males aged between 15 and 60 years were examined for cells and bacteria. Only 3 specimens showed pyuria, all of which yielded fastidious organisms. No specimen yielded a pure growth of an aerobe. Fastidious organisms in pure or mixed growth were isolated from 26% of the specimens, none in a count greater than 10(8)/l and the majority in counts less than 10(7)/l. It was concluded that pure growths of aerobes in any count in patients with symptoms are indicative of infection. Fastidious organisms should be sought in the urine of patients with symptoms or pyuria before more intensive and expensive investigations are pursued.

Adolescent↗
PubMed1989

Interstitial cystitis and the urethral syndrome: a possible answer.

A study was made of 20 patients fulfilling the criteria customarily used for the diagnosis of interstitial cystitis. A possible infective aetiology was sought by culture of bladder tissue, catheter and midstream specimens of urine, and urethral swabs by methods capable of detecting fastidious bacteria as well as aerobic pathogens. All bladder biopsies showed the histological appearances usually associated with interstitial cystitis, and bacteria were isolated from the catheter specimens and/or bladder biopsies of 12 patients. Eight of these isolates were fastidious bacteria, Gardnerella vaginalis (6) and Lactobacillus sp. (2). Fastidious bacteria were isolated from the midstream specimen of urine (MSU) and/or urethral swab of 6 other patients. The correlation of the histological and bacteriological findings supports the hypothesis of an infective aetiology and suggests that the so-called urethral syndrome and interstitial cystitis may be the earlier and later stages of the same disease process. The importance of early diagnosis of infection in these patients is emphasised.

Adolescent↗
PubMed1988

Microbiological look at urodynamic studies.

Urine samples were cultured for aerobic, fastidious, and anaerobic bacteria in 88 patients (66 F, 22 M) before and after standard urodynamic investigations. 37 of 42 women with detrusor instability, and 14 of 17 women with stress incontinence, had evidence of bacteriuria with aerobic or fastidious bacteria before investigation, as did 6 of 13 men with bladder outflow obstruction. 8 men (36%) acquired bacteriuria with aerobic bacteria after investigation, compared with 10 women (15%). Recalcitrant, irritative urinary symptoms in women may be caused by an underlying infection, the urodynamic changes being secondary. In men who have urodynamic studies, antibiotic prophylaxis should be considered.

Bacteriological Techniques↗
PubMed1987

A geographical focus of duplex ureter.

Following the observation of an unusually high number of patients presenting with duplex ureter in Dorchester, a prospective study of 1930 autopsies was carried out in nine centres throughout the Wessex region. The prevalence of duplex ureter in Dorchester was 2.5% (5 of 200 autopsies) but did not exceed 0.6% elsewhere. The finding was confirmed by study of intravenous urograms in south-west Dorset carried out between 1982 and 1983, which showed a 6.0% prevalence of urinary tract duplication in radiographs from Dorchester.

Adult↗
PubMed1976

Urinary infection in children in general practice: a laboratory view.

Children with urinary infection present at first to their general practitioners; paediatricians to whom they may be referred must assess the validity of the bacteriological diagnosis made at that time. With this in mind an analysis has been made of the laboratory findings in 2204 mid-stream urine specimens from 1586 children between the ages of two and 12 years examined at the request of their general practitioners during the course of one year. The contamination rate was shown to be low; 8% of the specimens from boys and 19% of those from girls showed definite infection, and the ratio of infections in boys to girls was 1:4. There was a considerable difference in the infecting organisms in the sexes. Analysis of the reasons for sending the specimens revealed that a high percentage of children who complained of urinary symptoms did not have infection. Of the children complaining of enuresis only there was a significantly greater incidence of infection in girls than in boys. In the absence of any large studies of urinary infection in domiciliary practice, data from a laboratory which serves many practitioners can contribute to knowledge of the disease.

Bacterial Infections↗