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Biomedical subjects

R M Parache

Publications and source records attributed to R M Parache.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Mixed mullerian tumours of the endometrium. Retrospective study, with prognostic aims, comparing their evolution to that of adenocarcinomas of the endometrium].

Mixed Mullerian Tumours (MMT) of the endometrium have a bad reputation as far as prognosis is concerned. We have studied 34 cases of MMT treated between 1976 and 1988 and have compared their outcome with a matched series of 68 cases of adenocarcinoma (ADC). These were taken out of 880 cases of ADC treated during this period of time after matching them for the stage, the type of treatment, the year of treatment and the age of the patient. The curves of survival and the totals of survival were determined using Kaplan-Meier's method and also compared using Logrank's test. The 5-years overall survival was 18% for MMT as against 55% for ADC (p less than 0.001). The difference was equally significant statistically in terms of specific survival without recurrences. The 16 patients in stages I and II who were treated with the same protocol as used for ADC were matched against 32 cases of ADC taken out of the 680 cases ADC in stages I and II and treated by the same protocol (84%). After five years MMT had a higher number of survivors (35% overall, 45% with specific survival and 35% without recurrences), but the difference with survival of ADC was as significant (respectively 75, 85, 85%). Recurrences of MMT were frequent (62%), with metastases in 9 out of 10 and early (50%), in every respect opposed with recurrences of ADC (16%) which were in three out of five cases localized and late (after 10 months). These figures make one have to think of modifying the way MMT is treated. External pelvic radiotherapy should be carried out before any other treatment. The place for other methods of therapy is to be discussed.

Adenocarcinoma↗
PubMed1991

[Muscle metastases of cancers].

In a retrospective study of cancer patients seen between 1980 and 1990, 7 cases of metastases to skeletal muscles were found: 2 primary bronchial carcinomas, 1 spindle cell sarcoma, 1 malignant melanoma, 1 ovarian adenocarcinoma, 1 squamous cell laryngeal carcinoma and 1 malignant neuroendocrine tumor from an unknown primary site. Despite their rich blood supply, skeletal muscles are rarely secondary metastatic sites (less than 1% of all malignant metastases of hematogenous origin); only 242 cases have previously been reported in 82 publications. Primary cancers of the lung, blood, gastrointestinal tract and genitourinary tract were the most frequently involved. Although skeletal muscle metastatic sites were rarely observed, the possibility of such a colonization should be known to physicians, as their detection requires specific tests. Furthermore, the localization of such sites clearly illustrates the recent progress made in the biology of metastases, especially the organ--or tissue--specificity of the site.

Adult↗
PubMed1991

[Immunohistochemical localization of transforming growth factor-beta (TGF-beta) in smooth muscle tissue].

Anti-TGF-beta antibodies were raised in rabbits against a C-terminal synthetic peptide whose amino acid sequence was chosen after human TGF-beta 1 primary sequence antigenic study by continuous epitope prediction. Immunopurified antibodies were used for an immunohistochemical localization in normal and pathological human tissues. Smooth muscular type tissue seems to be an elective target.

Animals↗
PubMed1990

The angiotensin I converting enzyme inhibitors, captopril and Wy-44,655 attenuate the consequences of cerebral ischemia in renovascular hypertensive rats.

Global cerebral ischemia (four vessel model) was induced in renovascular hypertensive rats (two kidney, one clip model) chronically treated with intraperitoneal administration of angiotensin I converting enzyme inhibitors, either captopril (100 mg/kg per day) or Wy-44,655 (10 mg/kg per day). Mortality following cerebral ischemia was higher in renovascular hypertensive rats than in normotensive controls. Reduction of blood pressure with captopril or Wy-44,655, lowered mortality. In surviving renovascular hypertensive and normotensive rats cerebral ischemia induced hyperactivity and lesions of the CA1 area of the hippocampus. Prolonged treatment with captopril--but not with Wy-44,655--reduced hyperactivity and the extent of the CA1 lesions. In conclusion, hypertension increases mortality following cerebral ischemia but does not affect the extent of brain injury in survivors. Prior treatment with converting enzyme inhibitors lowers mortality. Treatment with captopril attenuates brain injury in survivors.

Analysis of Variance↗
PubMed1984

Adenolipoma of the liver. A unique case with ultrasound and CT patterns.

Lipomas rarely occur in the liver. However, because of the widespread use of ultrasound and CT in the diagnosis of liver disease, one should be familiar with their appearance, as confirmed diagnosis may spare the patient major investigations. The value of CT is emphasized in association with percutaneous biopsy when the appearance of the tumour is not classical. Ultrasound patterns are discussed.

Adenoma↗
PubMed1983

[Histopathologic study of chronic sinusitis].

The conventional histopathology of the sinus is a criterium for the therapeutic indication, since it is possible to distinguish between granulomatous chronic sinusitis, chronic sinusitis with oedema and nasal polyposis. Each one of these clinical pictures has his own etiology and requires a specific therapeutic approach.

Chronic Disease↗
PubMed1981

[Epidermoïd carcinoma of uterine cervix with bone metastases in lower limbs (author's transl)].

Bone lesions are infrequent in the evolution of epidermoïd carcinoma of the uterine cervix. Direct bone invasion from the primary tumor, extension from lymph node metastases and distant metastases can be seen. The frequency of these lesions is about 3 to 4%. Hematogen bone metastases are very uncommon. They are often located in the lower limb. We report a case of a patient with a cervical carcinoma who developed isolated bone metastases in all the bones of a lower limb.

Bone Neoplasms↗