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Biomedical subjects

R M Raja

Publications and source records attributed to R M Raja.

At least 37 records · Page 2Linked to original sources
PubMed1985

Sodium-losing nephropathy and nephrocalcinosis after transplantation.

Severe, prolonged sodium-wasting (up to 38% FENa) occurred in a man after he received a cadaveric-donor kidney. Posttransplantation supplementation with large amounts of saline and/or salt tablets was mandatory. Fludrocortisone had no clinically apparent effect. Plasma renin activity and plasma aldosterone concentration were markedly increased. As chronic rejection progressed, the syndrome ameliorated. Renal biopsy showed cellular rejection and nephrocalcinosis.

Adult↗
PubMed1984

Lidocaine removal during resin hemoperfusion for phenobarbital intoxication.

A deeply comatose patient with severe phenobarbital intoxication was hemoperfused with an Amerlite XAD-4 column. She was receiving lidocaine for ventricular ectopy. The rate of lidocaine infusion had to be increased to control ventricular arrhythmias during hemoperfusion. Plasma clearance for lidocaine by the column was 122 ml/min at initiation and 75 ml/min at 2 h. These findings suggest that an increment in lidocaine infusion may be needed during resin hemoperfusion in patients receiving this drug because of its removal by the column.

Female↗
PubMed1983

Comparison of subclavian vein with femoral vein catheterization for hemodialysis.

Subclavian vein catheterization (SVC) is not widely accepted for vascular access because it is considered more invasive than femoral vein catheterization (FVC). The use of FVC and SVC for acute vascular access was compared for 9 mo each. Complications were minimal with both, but access related hospitalizations were lower and the number of out-patient dialyses performed were higher with SVC than FVC. Complications with SVC might have been minimized by using an 18-gauge metallic needle for insertion, avoiding interdialytic infusions and using SVC for less than 4 wk.

Catheterization↗
PubMed1983

Increment in dialysate sodium with sodium chloride or bicarbonate addition.

Hemodialysis was performed in 12 patients for 2 weeks each utilizing acetate dialysate containing 134 mEq/L sodium and dialysate containing 143 mEq/L sodium, achieved by the addition of sodium chloride or sodium bicarbonate to the acetate dialysate. Intradialytic morbidity was lower, dialysis hypoxemia less marked, and predialysis blood pH higher with the bicarbonate-than with the chloride-added dialysate. The long-term use of sodium bicarbonate-added dialysate in three patients was safe. Dialysate pH adjustment was not required. These findings suggest that the addition of sodium bicarbonate (50-75 g) to acetate dialysate may be preferred to sodium chloride for increasing dialysate sodium in selected patients.

Aged↗
PubMed1979

Amberlite hemoperfusion in the treatment of acute drug intoxication.

Hemoperfusion is more effective than hemodialysis in clearing drugs from the blood of patients with acute overdose. In addition, the clinical improvement in the depth of coma is dramatic during hemoperfusion. There is normalization of the respiratory and circulatory systems usually within one hour, and response to verbal command within a few hours of initiating treatment. Amberlite XAD-4 is an unchanged polystyrene resin with a particular adsorptive attraction for lipid-soluble drugs. It is a more effective adsorbent than some of the coated or uncoated carbons in clearing blood of most of the drugs commonly involved in life-threatening acute overdose.

Animals↗
PubMed1978

Long-term short hemodialysis-implications to dialysis index.

From this data, we conclude: 1) that dialysis therapy should be individualized to achieve optimal patient well-being; 2) that long-term hemodialysis for 8--12 hr/wk with 1.0--1.5 M2 coil dialyzers and 1.3--2.5 M2 Dow Cordis hollow fiber kidney is feasible and safe; 3) that most patients do well on hemodialysis, when DI is maintained at 0.9 to 1.1 with coil dialyzers and 0.75 to 0.85 with Dow Cordis hollow fiber; 4) that patients with creatinine clearance greater than or equal to 1.0 ml/min or with excessive interdialytic weight gain (greater than 3.0 kg) may acquire maintenance of a DI greater than 1.2 when utilizing coil dialyzers.

Adult↗
PubMed1978

High density lipoproteins--correlation with cardiovascular disease in hemodialysis patients.

1) HDL levels are low in hemodialysis patients. 2) Lipid abnormalities do not correlate with the presence of CVD in hemodialysis patients. 3) Smoking may not effect blood lipid levels in hemodialysis patients. 4) Nandrolone decanoate may not play a role in CVD in hemodialysis patients. 5) Longer time on hemodialysis does not result in a decrease in triglyceride or increase in HDL levels.

Adult↗