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Biomedical subjects

R M Rhatigan

Publications and source records attributed to R M Rhatigan.

12 recordsLinked to original sources
PubMed1992

Endocervical gland atypia secondary to Arias-Stella change.

Arias-Stella change of the endocervix is relatively common if a systematic search can be made. However, the change has rarely been described in cervical/endocervical biopsy material. Five additional biopsy cases of the Arias-Stella change of the endocervix are documented, briefly discussed, and compared with other endocervical gland abnormalities. The Arias-Stella change of the endocervix is important to recognize because of its atypical appearance that, in this location, can be mistaken for premalignant, malignant, or other glandular abnormalities, especially if the pathologist is not aware of the patient's pregnancy.

Adult↗
PubMed1991

Comparing the case materials available from a teaching hospital's autopsies in 1968 and 20 years later.

The Accreditation Committee on Graduate Medical Education requires both sufficient volume and variety of necropsy material for training in anatomic pathology. Since the number of autopsies has declined markedly in the last 20 years, the author sought to determine whether the variety of case material available from the autopsies performed at his teaching hospital had changed during that time span. Major diagnoses were abstracted from the reports of 200 autopsies of adults performed in 1968 and from a period 20 years later (1987, 1988, and part of 1989). Comparison between the two eras' diagnoses revealed very few changes in the incidences of various diseases. This was true even though the racial mix of patients had changed markedly. While declining autopsy rates are of concern, this study suggests that medical educators may not need to be concerned over the variety of autopsy case material. The author makes several suggestions for maximizing the teaching impact of each autopsy.

Adult↗
PubMed1991

Human papillomavirus in prostatic cancer: no evidence found by in situ DNA hybridization.

Human papillomavirus has been associated with benign squamous tumors, intraepithelial neoplasia, and invasive squamous cancer. The role of human papillomavirus as the most likely precursor of cervical dysplasia is well studied. We know of no available information as to the possible role of human papillomavirus in prostatic hyperplasia and cancer. We studied formalin-fixed paraffin-embedded tissues of 20 cases of glandular hyperplasia and 20 cases of prostatic cancer by in situ DNA hybridization for human papillomavirus using commercially available biotinylated DNA probes detected by an avidin-biotin peroxidase technique. We found no evidence of DNA hybridization to human papillomavirus-6, -11, -16, -18, -31, -33, or -35 in prostate tissue. Our results show no association between prostatic cancer or hyperplasia and the human papillomavirus genomes that were studied.

DNA, Viral↗
PubMed1979

Pneumococcal endocarditis in infants.

A case of pneumococcal endocarditis in an infant is reported together with a review of seven cases previously described in the literature. The prominent presenting symptoms of this usually fatal disease consisted of tachycardia, tachypnea, and cardiomegaly. A new murmur was heard in six of the eight patients. Fever was infrequent. Blood cultures were positive when done. The mitral valve was the site of infection in seven of the patients. In contrast to adult patients, pneumonia and meningitis are rarely encountered in children with pneumococcal endocarditis. The disease was fatal in all four patients before the penicillin era and in three of four patients who received penicillin.

Cardiomegaly↗
PubMed1979

Mucosal hyperplasia in clonic diverticula.

Benign, nonpolypoid mucosal hyperplasia has been consistently observed adjacent to colonic carcinomas. In order to determine the specificity of this association we looked for this type of mucosa in diverticulosis with or without diverticulitis, a disease thought not to be causally related to carcinoma. Nonpolypoid mucosal hyperplasis was frequently found within diverticula suggesting that this mucosal abnormality is, in some instances, unrelated specifically to malignancy.

Aged↗
PubMed1977

Mucoepidermoid carcinoma of the thyroid gland.

A 20-year-old euthyroid white woman presented with two palpable thyroid nodules. The scintiscan showed an area of increased uptake in the isthmus corresponding with one of the palpable nodules. The uptake in the rest of the gland was diminished including the area of the second palpable nodule which was in the superior portion of the left lobe. Microscopic examination revealed diffuse lymphocytic thyroiditis, follicular adenoma and the isthmus and mucoepidermoid carcinoma of the upper left lobe. No primary site for the muceopidermoid carcinoma outside the thyroid has been identified. Mucoepidermoid carcinoma of the thyroid gland has not previously been reported; the literature is briefly reviewed and etiologic considerations are discussed.

Adenoma↗
PubMed1977

Benign (nonpolypoid) mucosal changes adjacent to carcinomas of the colon. A light microscopic study of 20 cases.

Numerous reports deal with the presence or absence of remnants of benign polyps adjacent to colonic carcinomas. Little attention has been paid to light microscopic mucosal alterations of a nonpolypoid nature found adjacent to these neoplasms. The general assumption has been that this mucosa is normal or not significantly altered. In this presentation we describe nonpolypoid mucosal changes found adjacent to 20 randomly selected carcinomas of the colon. We found these changes to be variably but consistently present. Their possible significance is briefly discussed.

Adenocarcinoma↗
PubMed1977

Unilateral salpingitis due to Enterobius vermicularis.

A case of perforated unilateral salpingitis in which Enterobius vermicularis ova were identified in the inflammatory process is reported. Arguments for considering the parasite to be of etiologic significance in the production of the pathologic changes and clinical symptoms are presented. The infrequent occurrence of symptoms associated with ectopic localization of Enterobius vermicularis is emphasized by a review of the literature.

Adult↗
PubMed1977

Condyloma acuminatum and squamous carcinoma of the vulva.

Reported is the association of condyloma acuminatum and squamous carcinoma of the vulva in three cases and condyloma followed by squamous dysplasia in a fourth case. This association has previously been reported in both male and female genitalia and in the perianal area. In our four cases, cancer or squamous dysplasia followed long-standing or extensive condyloma, but there was no evidence of transformation from condyloma to carcinoma. In one of the cases, areas of squamous dysplasia occurred in multiple foci within a large condyloma. It is not known whether condyloma acuminatum is a precancerous skin lesions, but long-standing or extensive condylomas should alert one to the possibility of carcinoma.

Adult↗