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Biomedical subjects

R M Robbins

Publications and source records attributed to R M Robbins.

4 recordsLinked to original sources
PubMed1975

A model for steroid effects in herpes keratitis.

Dextran-Blue 2000 was used as a marker to determine the effect of steroids on large molecule transfer through the cornea. In superficially scarified corneas topically applied steroids greatly enhanced the transfer of this chromophore through the cornea in the in vivo state, but had little effect in vitro. This implies that the steroid effect is an active process. Since herpes simplex virus is approximately the same molecular weight and configuration as the chromophore used, this study explains one aspect of how steroids may be detrimental when used in the presence of this virus.

Animals↗
PubMed1975

Surgical landmarks in trabecular surgery.

Clinical and histologic studies in 40 eyes of 35 patients with chronic open-angle glaucoma or chronic angle-closure glaucoma operated by various types of "trabeculectomies" were assessed to evaluate whether success was correlated with the surgical approach or with the presence of trabecular tissue in the pathologic specimen. It was clearly demonstrated that it is not necessary to localize or enter Schlemm's canal in order to perform successful trabeculectomies; it is not necessary to operate posterior to the scleral spur; and it is not necessary to excise either Schlemm's canal or trabecular tissue to achieve success. In essence, trabeculectomies primarily function as fistulizing operations carried out under scleral flaps substituting a scleral-conjunctival barrier to aqueous flow rather than the conjunctival barrier alone provided by standard glaucoma operations. This greater obstruction explains the absence of shallow chambers, the reduced incidence of polycystic bleb formation and, perhaps, an avoidance of long-term complications that often result from these two factors.

Glaucoma↗