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Biomedical subjects

R M Ross

Publications and source records attributed to R M Ross.

29 records · Page 2Linked to original sources
PubMed1985

The use of growth hormone-releasing hormone in the diagnosis and treatment of short stature.

We have assessed the role of growth hormone-releasing hormone (GHRH) as a diagnostic test in 40 children and young adults with growth hormone deficiency (GHD), principally using the GHRH(1-29)NH2 analogue. Following 200 micrograms GHRH as an acute intravenous bolus, serum GH rose to normal or just subnormal levels in 13 out of 17 children with structural lesions, and in 8 of 14 patients with idiopathic GHD or panhypopituitarism. Of 9 children (mean age 12 years) with GHD following treatment with cranial irradiation for nonendocrine tumours, all responded acutely to GHRH. 12- and 24-hour infusions with GHRH(1-29)NH2, and 1- and 2-week treatments with twice-daily subcutaneous GHRH(1-29)NH2, showed persistent stimulation of GH release. It is concluded that many children with GHD of diverse aetiology will respond both acutely and chronically to treatment with GHRH.

Adolescent↗
PubMed1983

Measurement of plasma prostaglandin E2 using capillary gas chromatography negative ion chemical ionization mass spectrometry.

A stable isotope dilution assay for the measurement of plasma prostaglandin E2 (PGE2) employing capillary column gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS) is described. PGE2 was extracted from plasma using C18 and silica SEP-PAKS. Further purification and separation was accomplished by thin layer chromatography. The prostaglandin was analyzed as its pentafluorobenzyl ester-methoxime-trimethyl-silyl ether, using fragment ions at m/e 524 (protium) and m/e 528 (deuterium) for quantitation. The mean plasma concentration of PGE2 determined in 8 healthy volunteers was 2.8 +/- 2.0 pg/ml.

Adult↗
PubMed1981

Anhidrotic ectodermal dysplasia with transient hypogammaglobulinemia.

An 8-month-old white boy with anhidrotic ectodermal dysplasia (AED) who was referred to the North Carolina Baptist Hospital because of recurrent respiratory infections and hypogammaglobulinemia is presented. His mother had partial expression of AED suggesting x-linked recessive inheritance in this family. She was incidentally given oral glucocorticoids during pregnancy for the treatment of chronic urticaria. The patient's serum immunoglobulins G, A and M were low at 8 months but normal by 15 months of age, and immunologic evaluation failed to show a defect in antibody production or cell-mediated immunity. Although rare, the diagnosis of AED must be considered in infant boys with recurrent fever and respiratory infections. The diagnostic features of the disease may be subtle in young child prior to the eruption of the characteristic peg-shaped teeth.

Agammaglobulinemia↗
PubMed1981

Hepatic dysfunction secondary to heart failure.

The case reports of five patients who manifested severe hepatocellular injury secondary to heart failure are presented. All had evidence of severe left ventricular dysfunction and low cardiac output state. The clinical findings of right heart failure were variable and not always present. Liver histology, when obtained, revealed evidence of centrilobular necrosis (CLN). Rapid normalization of the biochemical abnormalities occurred in all patients, irrespective of clinical improvement of their cardiac status.

Aged↗
PubMedDate not supplied

Measurement of plasma prostaglandin F2 alpha using capillary gas chromatography negative ion chemical ionization mass spectrometry.

A stable isotope dilution gas chromatography/mass spectrometry method for the measurement of prostaglandin F2 alpha (PGF2 alpha) in plasma has been developed. The linearity of the method was 0 to 250 pg per ml, day-to-day precision of five percent at a level of 80 pg per ml, and a limit of detection of one pg per ml. Evaluation of the absolute recovery of PGF2 alpha through the sample clean-up steps using tritium labelled PGF2 alpha gave recoveries of 68 +/- 5 percent. A preliminary reference range estimated a mean plasma PGF2 alpha level of 83 +/- 13 pg per ml (n = 7) with a range of 62 to 103 pg per ml in healthy adults. The major application of this method will be in research protocols studying changes of PGF2 alpha in toxemia of pregnancy.

Adult↗