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Biomedical subjects

R M Zaslavskaia

Publications and source records attributed to R M Zaslavskaia.

At least 19 recordsLinked to original sources
PubMed2005

[Effectiveness of metabolic preparations in complex treatment of elderly patients with postinfarction cardiosclerosis and circulatory insufficiency].

The paper presents the results of an examination of 129 elderly patients with CHD who had had a myocardial infarction and suffered from II-III functional class heart failure. The patients were divided into four groups. The patients in the first group were administered complex therapy (CT) only; the second group received CT plus a composition of replaceable amino acids (CRAA) sublingually and orally, the third group received CT plus a placebo and the fourth--CT plus melatonin in doses of 3 and 6 mg. The efficiency of the treatment was assessed by the dynamics of clinical manifestations and by means of echoCG and Holter ECG-monitoring; parameters of lipid peroxidation and antioxidative protectability in erythrocytes were measured. The comparison of the results suggests that addition of CRAA and melatonin in a dose of 6 mg to CT is more effective than CT only. This was proved by the more pronounced positive dynamics of clinical symptoms, the improval of the myocardial contractility and normolizing influence on the balance in the oxidant/antioxidant system.

Administration, Oral↗
PubMed2005

[Efficacy of conventional mono mac therapy and mono mac chronotherapy of painless myocardial ischemia in patients with insulin-independent diabetes].

60 patients, suffering from coronary heart disease with painless myocardial ischemia (PMI) and insulin-independent diabetes (IID), were randomized into two groups. The first group included 18 patients, who received conventional mono mac therapy in a dose of 20 mg twice a day, the second--42 patients, whose treatment consisted in mono mac chronotherapy, i.e. they were administered a single dose of 10 to 20 mg of the drug 30 minutes before a PMI episode, revealed by means of Holter ECG-monitoring, before the beginning of the treatment. All the patients underwent examination, which consisted in Holter ECG-monitoring and Echo-CG, before and after a 15-day mono mac therapy course and adequate IID treatment. The study demonstrated that the total length and number of PMI episodes within a 24-hour interval, as well as the average episode length, were significantly less in the second group, compared with conventionally treated patients. The chronotherapy allowed a 2-fold reduction in mono mac doses.

Aged↗
PubMed2005

[ECG and BP monitoring in patients with stable angina and essential hypertension on therapy with monocinque].

The authors studied ECG and arterial pressure (AP) parameters in 24 patients with stable angina and arterial hypertension aged 57.9 +/- 1.6 years, receiving 14-day complex therapy including administration of monocinque in a dose of 20 mgs 2 times a day. A portable Digitrak-Plus Zymed Holter 1810 device (USA) was used to monitor ECG, and a portable Meditech ABPM-04 device (Hungary)--to monitor AP. The therapy substantially reduced episode frequency as well as total length and amplitude of ST segment depression. At the same time, the patients displayed decrease of day and night systolic and diastolic AP, as well as of their mean daily values.

Adult↗
PubMed2004

[Effects of nebuliser treatment with berotec on external respiratory function, bronchial permeability, hemodynamics, acid-alkaline balance, oxygen saturation, and their circadian structure in elderly patients with chronic obstructive pulmonary disease].

AIM: To study the effects of nebuliser therapy with berotek on clinical symptoms, external respiration function (ERF), bronchial permeability, hemodynamics and their temporal organisation in elderly patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: The study enrolled 20 COPD patients (mean age 64.9 +/- 1.9 years) with obstructive respiratory insufficiency of the second-third degree given nebuliser therapy with berotek as adjuvant to conventional treatment (the study group) and 12 COPD patients (mean age 69.7 +/- 2.5 years) given only conventional treatment (the control group). The following parameters were examined: ERF, BP, HD, AAB, OS (SaO2) in venous blood before and after treatment. Chronobiological studies of BP and HD were performed for 7 days at the beginning and end of the study. RESULTS: Berotek efficacy manifested on the treatment day 3 as improvement in the symptoms, IRF, BP, a rise in SaO2 and PaCO2 and a fall in PaCO2 in venous blood. Circadian chronostructure of peakflowmetry, systolic and diastolic blood pressure, mean arterial pressure persisted. Circaseptal and circasemiseptal rhythms of BP and HD disappeared. CONCLUSION: Nebuliser therapy with berotek has a positive effect on clinical symptoms, ERF, BP, gas exchange in the lungs, SaO2, HD and their circadian chronostructure.

Acid-Base Equilibrium↗
PubMed2004

[Pharmacodynamics of nonessential amino acids in elderly patients with post-infarction cardiac sclerosis].

We studied pharmacodynamics of an amino acids complex (AAC) in 60 elderly patients (a mean age 71.6 years) with ischemic heart disease, postinfarction cardiosclerosis (PIC), circulatory insufficiency stage I-II. The patients were randomized into 3 groups, 20 persons each. Group 1 received standard therapy (ST) and placebo, group 2--ST + AAC (one tablet of 70 mg 3 times a day), group 3--ST + AAC sublingually in the same dose. Clinical symptoms, results of ECG Holter monitoring and echocardiography were assessed before the treatment and on treatment day 18. Positive effects of AAC used in combination with ST in relation to clinical symptoms, myocardial contractility and ischemia. No differences in efficacy were observed with oral and sublingual AAC administration.

Administration, Oral↗
PubMed2004

[Temporal organization of external respiratory function in elderly patients with chronic obstructive lung disease].

The clinical course and the circadian, circaseptan, and circasemiseptan chronostructure of external respiratory function (ERF) were studied in 26 elderly patients with chronic obstructive lung diseases before and after routine therapy (RT). ERF was studied on a meta-test spirograph (Russia) and a Ferraris medical peak flowmeter (UK). The values of ERF and bronchial patency were measured every 4 hours within 7 days before and after 10-day RT. The latter included euphylline, expectorants, and antibacterial drugs, if indicated. The patients also use "on-demand" dosage aerosol inhalators not more than 3-5 times a day. The chronobiological data were analyzed by the averaged group cosinor test described by F. Halberg. The results of the study made it possible to detect the impaired temporary organization of ERF and bronchial patency, the phenomena of external and internal desynchronism both prior to and following RT. It clinical effect occurred on day 5.5 after RT. Before RT, circadian variations were found in respiratory volume (RV), respiratory minute volume (RMV), vital capacity (VC), forced expiratory value per sec (FEV1), the Tiffeneau test, and peakflowmetry. After RT, they remained other than variations in RV. The average daily values of VC, FEV1, Tiffeneau test, PO2, and KIO2 statistically significantly increased. The increases of MESORs and other indices tended to be significant. Circasemiseptan variations were found in RV, VC, and FEV1 before RT. After treatment, these were detected in respiration rate (RR), RMV, VC, and KIO2. The MESORs of RMV, VC, FEV1, and KIO2 statistically significantly increased. Prior to and following RT, there were virtually no 7-day (circaseptan) variations, other than those in RR before therapy. The MESORs of VC, FEV1, MVL, and RD statistically significantly increased. The MESORs of other parameters of ERF tended to be significant. Thus, RT led to the improved circadian and circasemiseptan organization of ERF and, to a lesser degree, to that of circaseptan chronostructure of the parameters of ERF.

Aged↗
PubMed2004

[Efficacy of emoxypine in combined therapy for elderly patients with postinfarct cardiosclerosis and heart failure].

Forty-four patients with coronary heart disease, angina pectoris, prior myocardial infarction, and NYHA Functional Class II-IV heart failure were examined. Group 1 patients received emoxypine during combined therapy (CT). Group 2 patients took CT alone (a control group). The results of the study suggest that emoxypine significantly improves the clinical symptomatology and shows marked antianginal and antiischemic effects. As compared with the control group, Group 1 shows a more significant hemodynamic improvement. Moreover, the inclusion of emoxypine into CT for elderly patients with prior myocardial infarction produces a normalizing effect on oxidative stress. By taking into account the foregoing, it should be stated that it is expedient to include emoxypine into CT for this category of patients.

Adrenergic beta-Antagonists↗
PubMed2003

[Effects of altiazem PP and dilren on clinical symptoms, hemodynamic parameters and their chronologic structure in patients with stable angina].

Effects of altiazem PP-180 ("Berlin Chemie", Germany; "Menarini Group". Italy) and dilren-300 ("Sanofi", France) on clinical symptoms and circadian hemodynamic chronostructure were studied in 22 patients with coronary heart disease (CHD) with stable angina pectoris of functional class II-III. Tetrapolar chest rheography (TCR), echocardiography (Echo-CG), ECG, arterial pressure measurement (APM) by N. S. Korotkov were used for examination. TCR, ECG and APM were made 6 times a day: at 10.00, 14.00, 18.00, 22.00, 02.00 and 06.00. The drugs were given in a single daily dose at 08.00 for 10 days. The information was processed statistically and by F. Halberg's cluster analysis. The results showed that altiazem PP and dilren had an antianginal activity which is stronger in dilren administration. The drugs produced moderate hypotensive and vasodilating effects. Altiazem PP raised mean daily level of stroke and minute volumes and their indices. Dilren raised ejection fraction and reduced the double product. Dilren normalized chronostructure of hemodynamic circadian rhythms.

Adult↗
PubMed2003

[Optimization of sanatorium treatment of patients with essential hypertension stage II by chronotherapy].

A comprehensive chronodiagnostic examination and treatment were performed in 45 patients with essential hypertension stage II aged 37 to 68 years taking 21-day treatment at sanatorium Osetia. The patients were divided into 2 groups: 20 patients of group 1 received basic antihypertensive treatment (enap, hypothiaside) and sulfurated hydrogen balneotherapy not adjusted to individual biorhythm; 25 patients of group 2 received the same treatment by adjusted to biorhythmic phases of basic cardiovascular indices and chronotype established according to Estberg's questionnaire. Estimation of the rhythms of the integral indices of physiological functions (systolic and diastolic arterial pressure, heart rate, body temperature) and "individual minute" was made within 3 days in 4-h intervals. Hemodynamics was studied before and in the end of the treatment with echocardiography, dopplerechocardiography and rheoencephalography. Positive shifts were registered in both groups: a significant fall in arterial pressure, total peripheral vascular resistance, double product and cardiac performance. Patients of group 2 had greater number of significant rhythms of physiological function parameters, primarily circadian, more frequent recovery of amplitude and phase parametric characteristics, better improvement of cerebral circulation, contractile and diastolic functions of the myocardium, reduction of the required medication doses and 2-fold lowering of side effects rate.

Adult↗
PubMed2002

[Advantages of capoten chronotherapy of patients with hypertension in an outpatient setting].

AIM: To compare the efficiency of a short course of preventive chronotherapy and traditional therapy with capoten in an outpatient setting. MATERIAL AND METHODS: Forty-two patients with stage II essential hypertension were divided into 2 groups: 20 controls were treated with capoten in a dose of 12.5-50 mg 3 times a day and 22 received capoten once a day in the same single dose 1.5-2 h before arterial pressure (AP) acrophase. Central hemodynamics was studied by echocardiography, regional hemodynamics by reheoencephalography before and at the end of therapy. RESULTS: In the control group AP normalized after capoten therapy in 3 patients, decreased by at least 10% but did not normalize in 9, and did not change in 8 patients. The results in the chronotherapy group were as follows: AP normalized in 5, decreased by at least 15% in 13, and did not change in 4 patients. Normalization of daily profiles of hemodynamic values and more favorable shifts in the cerebral bloodflow were more often seen in patients who received chronotherapy. CONCLUSION: Capoten chronotherapy of patients with essential hypertension, carried out in an outpatient setting, is obviously preferable to traditional treatment: no side effects were observed and a better hypotensive effect was attained with lower total dose.

Adult↗
PubMed2002

[Effects of aspirin standard therapy and chronotherapy on circadian organization of hemocoagulation in patients with insulin-dependent diabetes mellitus].

24-h profile of hemocoagulation was assessed in 30 patients with insulin-dependent diabetes mellitus type 1 aged 17-37 years. The patients were randomized into 2 groups, 15 patients each. Patients of group 1 received aspirin by conventional scheme: 125 mg 3 times a day for 16 days. Patients of group 2 received aspirin as preventive chronotherapy: once a day in a dose 125 mg for 16 days two hours before the acrophase of platelet aggregation rhythm--at 22 p.m. Parameters of plasmic and platelet hemostasis in blood samples were measured at 3.00, 7.00, 11.00 a.m., 15.00, 19.00, 23.00. The above chronobiological information was processed by Kosinor-analysis according to F. Halberg. Before the treatment, hypercoagulation with night rise as well as external and internal desynchronism of the hemostasis circadian rhythms were observed. Conventional aspirin treatment improved hemostasis but influenced acrophases minimally. Aspirin chronotherapy promoted normalization of circadian organization of hemocoagulation.

Adolescent↗
PubMed2002

[Assessment of time-dependent effects of long-acting altiazem in patients with hypertension stage II].

A chronodiagnostic examination covered 27 patients with hypertension stage II of indifferent chronotype. The patients were divided into 3 groups by the time of intake of a single daily dose of altiazem--at 8 a.m., 14 p.m., 20 p.m. Chronological organization of the cardiovascular system was studied with autorhythmometry for 3 days in 4-h intervals including night before and in the end of the treatment. Echo-CG, doppler echocardiography and rheoencephalography investigated hemodynamics once daily also before and in the end of the treatment. The findings show advantage of chronotherapeutic prescription of altiazem PP in a mean dose 220 mg/day at evening hours in non-chronodependent patients with hypertension stage II because such a regimen brought about more adequate restoration of the cardiovascular system time organization both by the spectrum of significant rhythms and their parameters; by better improvement of left ventricular diastolic function and pulse cerebral flow. Faster achievement of the therapeutic effect in the evening intake of altiazem supports its chronotherapeutic administration. This leads to reduction of the drug course dose and, therefore, treatment duration.

Adult↗
PubMed2002

[Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].

Effects of amino acid composition MP-33 in combination with trimetazidine were studied in metabolic therapy of elderly patients (age 63.3 +/- 1.7 years) with ischemic heart disease (angina pectoris functional class II-III). MP-33 (100 mg 3 times a day subling.), trimetazidine (20 mg 3 times a day per os), trimetazidine + amino acid composition MP-33 in the above doses in addition to basic therapy were given to 30, 15 and 15 patients, respectively. Combined therapy with trimetazidine and MP-33 significantly activated antioxidant enzymes and depressed lipid peroxidation due to GSH-dependent regulation of cellular redox status by MP-33.

Adult↗
PubMed2002

[Cilazapril in the treatment of patients with arterial hypertension].

Effects of monotherapy with cilazapril, cilazapril in combination with hydrochlorothiazide and the latter two drugs combination with verapamil (or obsidan) were studied in 20 patients with mild arterial hypertension (AH), moderate AH (n = 23) and severe AH (n = 22). Cilazapril was administered in a single daily dose of 2.5-5 mg for 24 weeks. Four measurements of arterial pressure, echocardiography, estimation of total cholesterol, triglycerides, glucose tolerance tests were made before the treatment and on its weeks 4, 12 and 24. Mono- and combined therapy with cilazapril proved effective in the above patients as it optimally lowered blood pressure and induced a reverse development of left ventricular hypertrophy. 24 week therapy with this drug has a positive effect on the level of triglycerides and postprandial glycemia.

Adult↗
PubMed2001

[Chrono-pharmacodynamics of capoten in patients with ischemic heart disease, postinfarction cardiosclerosis with cardiac failure].

Hemodynamic parameters were measured before and 30 min, 1, 2 and 3 hours after intake of 12.5 mg capoten in acute pharmacological test at 7.00, 10.00, 13.00, 16.00, 19.00 and 22.00 in 70 patients with ischemic heart disease, postinfarction cardiosclerosis with heart failure stage I-II. The patients were randomized into 6 groups according to the time of the pharmacological test. As shown by tetrapolar chest rheography, the lowest peripheral vascular resistance and the highest cardiac ejection occurred if capoten was used at 10.00. In contrast, vascular resistance rose and cardiac ejection fell in capoten intake at 13.00. At the other hours circulation responded more favourably than at 13.00 but not so strongly as at 10.00. Different hemodynamic reaction to capoten within 24 hours demands further studies.

Aged↗
PubMed2000

[Effects of metabolic therapy on intracellular level of antioxidant system in elderly patients with ischemic heart disease].

Patients with ischemic heart disease (angina pectoris of functional class II and III) whose mean age was 67.4 +/- 1.67 years were divided into 3 randomized groups. 15 control patients received standard treatment. 30 and 15 patients of group 1 and 2, respectively, received standard treatment plus amino acid composition (100 mg 3 times a day sublingually) or preductal (20 mg 3 times a day)--groups 1 and 2, respectively. The treatment lasted 21 days. Before the treatment and on its day 1, 7 and 21 measurements were made of glutathione level, activity of glutathion-dependent enzymes, catalase, Cu, Zn-superoxide dismutase and malonic dialdehyde in red cells. The amino acid composition was found to raise the level of antioxidant system and suppress lipid peroxidation. Preductal raised the activity of Cu, Zn-superoxide dismutase and had an unbalanced effect on the antioxidant system.

Aged↗
PubMed2000

[Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension].

Fifty patients (mean age 53.8 +/- 3.45) with arterial hypertension were examined. They were divided into 2 randomized groups, 25 patients each. One group received moxonidine, 40 mg, alone in the morning, the other had moxonidine in the same dose in combination with melatonin, 3 mg, overnight. The treatment lasted 14 days. Monitoring of blood pressure (BP), heart rate (HR), EchoCG was made before and after treatment. The studies indicated that moxonidine had a pronounced antihypertensive effect by slightly lowering BP overnight and that the chronostructure of BP and HR rhythms was impaired. Addition of melatonin to the moxonidine therapy with greater antihypertensive effects made the chronostructure of circadian BP and HR rhythms normal.

Antihypertensive Agents↗