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Biomedical subjects

R Möllmann

Publications and source records attributed to R Möllmann.

7 recordsLinked to original sources
PubMed1989

[Therapeutic study of the effect of selective decontamination on microbial overgrowth syndrome of the small intestine].

The microbial overgrowth syndrome of the small bowel (MOS) is characterized by clinically found symptoms of increased metabolic activities of microorganisms existing in a great number in the intestinal juice of these patients. We treated 15 patients who suffered from MOS following a modified scheme of selective intestinal decontamination (SID) with oral doses of BerlocombinR (trimethoprim/sulfamerazin) and polymyxin for three weeks. Comparative investigations of duodenal juices before and after treatment showed unchanged high germ-counts (total aerobes and total anaerobes up to 10(7) germs/ml juice). Only the increase of Clostridium (up to 10(6)/ml) was statistically significant which has to be disapproved. In most of the patients there was no subjective improvement. SID in the examined manner is not able to cure a microbial overgrowth in the upper gastrointestinal tract or to reduce facultatively pathogenic microorganisms.

Adult↗
PubMed1987

[Whipple's disease, an example of interactions between gastrointestinal flora and the macroorganism?].

Morbus Whipple is known as a systemic disease caused by bacteria and inducing the formation of mucopolysaccharides which is absorbed by macrophages. In a mucosal bioptate of a 60 years old patient suffering from this disease we could prove numerous rod-shaped bacteria (Propionibacterium) by electronmicroscopy. In the duodenal secretion aerobic and strictly anaerobic bacteria were to be found. Therapy with tetracycline was followed by a fast and distinct improvement of the clinical symptoms of the absorption disturbances but not so clear of the histological findings.

Digestive System↗
PubMed1986

[Microbial pathogenesis of Whipple's disease].

In a case of Whipple's disease with electron microscopic demonstration of rod-shaped bacteria we could isolate Propionibacterium acnes (former name: Corynebacterium anaerobium), Actinomyces, and Lactobacillus from duodenal biopsies by the aid of modern anaerobic culture technique. Simultaneously we found a dysbiosis (increase of anaerobic coca and anaerobes) in du odenal juice. After antibiotic treatment Propionibacterium and Lactobacillus disappeared and an other type of dysbiosis (appearance of Bacteroides) was to be seen. In discussion is a change of immunologic state and following disturbed regulation of microbial colonization in the small bowel of patients with Whipple's disease.

Bacteria↗
PubMed1983

[Results of sonographic kidney diagnosis].

In a prospective study of the examination of the accuracy of the ultrasound tomography in the renal diagnostics the kidneys of 361 patients could be demonstrated as at 100% sufficiently to be judged. Tumours, congestion kidneys, cystic kidneys/renal cysts and cirrhoses of the kidney were diagnosed with an efficiency of 0.92-0.96-0.97-1.0. The sensitivity was in the same order 0.90-0.96-0.99-1.0 and the specificity 0.94-1.0-0.95-1.0. Insufficient results were obtained by the sonographic search for renal calculi. As non-invasive and rapid method of diagnostics the sonography in a valuable way contributes to the differentiation of the symptom "quiescent kidney" and oligo-anuria.

Humans↗
PubMed1979

[Automatic regeneration of capillary dialysers].

First results of an automatically working regeneration apparatus for capillary dialysators in 200 dialyses allow the on an average tenfold use of the dialysator CDAK 4. In this case a reduction of the effective surface to 70% of the initial value must be taken into bargain. Pyrogenic reactions or bacterial contamination of the regenerated dialysators were not taken into consideration. This method is recommended as transitional solution up to the industrial production of cheap dialysators for a single use.

Kidneys, Artificial↗
PubMed1975

[Measurement of kidney function using combined PAH-inulin clearance before and after bactericide treatment of chronic pyelonephritis].

On account of the solution of the problem, whether already after a four weeks' therapy with antibiotics in chronic progressing pyelonephritis a measurable increase of function may develop, the combined PAH-inulin-clearance was performed 35 times. 9 patients did not show a clear restriction of the clearance, wherefore in these cases a control examination was not necessary. In 10 patients of 12 an increase was present, in 7 patients a significant increase of the renal function existed after the therapy carried out. Therefore already after antibiotic impact therapy in patients with chronic pyelonephritis without provable acute episode an improvement of the function can occur, which is to be increased or kept by means of the long-term treatment.

Aminohippuric Acids↗