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Biomedical subjects

R Mach

Publications and source records attributed to R Mach.

32 records · Page 2Linked to original sources
PubMed1992

[Treatment of climacteric syndrome using Estraderm TTS and premarin in a comparative study].

In an open-label, multicentric randomized trial the efficacy and tolerability of Estraderm TTS, a 17 beta-estradiol, and Premarin, consisting of conjugated estrogens, were compared in the treatment of the climacteric syndrome. 84 patients with manifest menopausal complaints were randomized into two groups of 42 women each. The duration of treatment was 11 weeks or 3 cycles, each with 3 weeks of estrogen treatment followed by a therapy-free week. Therapeutic efficacy was assessed with a questionnaire recording frequency and intensity of hot flushes and of sweating episodes during the night, changes in psychic well-being, frequency of micturition and dryness of the vagina. Systemic and local tolerability was also evaluated. Both substances proved almost equivalent in the treatment of menopausal complaints, although Estraderm TTS was markedly superior in suppressing vasomotor symptoms.

Administration, Cutaneous↗
PubMed1992

[Steroid glaucoma in severe atopic keratoconjunctivitis. A reminder for possible therapy with plasmapheresis].

In 1989 in the authors' hospital four plasmaphereses were performed in a patient treated with steroids on account of severe atopic keratoconjunctivitis with suspicion of hyperimmunoglobulinaemia IgE. As a result of treatment of the basic disease the patient developed steroid glaucoma. The authors recommended as alternative treatment plasmapheresis in order to discontinue corticoid therapy. Three months after the fourth plasmapheresis the intraocular tension improved and is still within a normal range.

Adult↗
PubMed1992

[Thrombolysis of arterial retinal occlusion using urokinase].

The authors present an account on possible aimed thrombolytic treatment of occlusion of the retinal artery by urokinase. Aimed thrombolysis can be performed at ophthalmological departments with an available radiodiagnostic department, which performs angiographies of carotid arteries. The authors discuss the necessary dose of 200,000 to 300,000 i.u. of urokinase. One-hour infusion with an initial booster dose is best. Early administration of the preparation is considered most important by the authors. The authors present the case-history of a 34-year-old patient with complete occlusion of the central retinal artery with haemodynamically severe aortal stenosis with a congenital background. Urokinase was administered six hours after occlusion of the artery. Gradually reperfusion of the retina occurred and improvement of the visual acuity from 0.01 to 0.17 with a residual relative wedge-shaped loss of the visual field and paleness of the disc of the optic nerve.

Adult↗
PubMed1989

[The use of disposable draping materials in the operating room and its effect on the postoperative wound infection rate].

In a consecutive study we analyzed the influence of gown and drape material on the postoperative wound infection rate. 1033 operations were included in this study. In 354 operations conventional cotton gowns and drapes were used, while in 679 operations, a disposable gown and drape system was utilized. The use of disposable gown and drape material reduced the postoperative wound infection rate in our surgical department. The greatest reduction -43% - was seen in clean wounds. Within this group gallbladder operations showed a reduction of 59% and hernia operations showed a reduction of 46%. A slight reduction was also seen in clean-contaminated and contaminated wounds, while in dirty wounds there was no difference. However, due to the relatively low numbers involved the results were not of statistical significance. An analysis of the costs over a 12-month period showed a reduction of 7.5% when the disposable gown and drape system was used. With respect to ease of handling and wear the disposable material was preferred by the operating-staff, both doctors and nurses.

Bedding and Linens↗
PubMed1989

[Occlusion of the central retinal vein in hemodialyzed patients].

The authors describe the acute development of an occlusion of the main retinal vein in six patients enlisted in a chronic dialyzation programme. It is a very serious ophthalmological complication which caused substantial diminution of visual acuity, and where haemorrhagic glaucoma developed (4 patients), loss of the eye. In investigations of these patients enlisted in chronic dialyzation programmes pathological findings on the ocular fundus are decisive. Patients with hypertonic neuroretinopathy on the ocular fundus run the greatest risk of occlusion of retinal vessels, in particular in the first year after enlistment in the programme. Impaired blood clotting in these patients certainly also plays a part in the development of the occlusion.

Adult↗
PubMed1989

[Combination therapy of the retina in diabetic retinopathy].

Authors refer experiences with the complex therapy of diabetic retinopathy combining laser photocoagulation with cryocoagulation. Various indications and techniques of treatment were described. Equatorial cryocoagulation is advantageous with respect for its rapid performance without excessive loading of the patient and has similar effects as photocoagulation. Cryocoagulation is recommended as the operation of first choice in cases of the partial intravitreal hemorrhage. Cryocoagulation was performed in 51 eyes, 43 of them was followed for the mean period 7.2 months, with additional photocoagulation. After the cryocoagulation, which was preceeded or followed by photocoagulation, the visual acuity was measured one month after the operation and in 18 patients (42%) was improved, in 6 patients (14%) worsened. After one year in 12 followed patients 3 of them were improved, 7 patients worsened. Partial intravitreal hemorrhage with vision 6/60 and better was during one month sufficiently absorbed as to perform the further photocoagulation.

Combined Modality Therapy↗