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Biomedical subjects

R Maerker

Publications and source records attributed to R Maerker.

At least 19 recordsLinked to original sources
PubMed1996

[Indications for various reconstruction and osteosynthesis methods in surgical management of subcondylar fractures of the mandible].

We do not advocate routine open reduction in subcondylar fractures, but there are some indications for surgical treatments. If we have decided for open reduction, the risks must be weighed against the benefits. If we are not sure, that the condyle is in a correct position, we avoid rigid internal fixation and we prefer only a temporary stabilization with resorbable Polydioxanone, Polylactide or autologous bone-pins. In non oblique fractures, we recommend only open reduction without further internal fixation. The advantage is that the condyle has the ability to move into a physiologic position and there is no need to remove metal implants in a second operation, the disadvantage is that we cannot avoid MMF and functional therapy, but our experience shows that the functional therapy can be shortened. Resorbable- and bone-pins could not take place of miniplates or traction-screws, but in selected cases, they could enlarge the surgical treatment in subcondylar fractures.

Adolescent↗
PubMed1982

Late results following different methods of cleft lip repair.

This is a review of the cleft lip repair of 232 patients. Three groups were compared, one repaired according to the Hagedorn-Le Mesurier-Steffensen technique, another by the Tennison method and a third using the Pfeifer wave-line procedure. Muscular union was best following Pfeifer's wave-line procedure. Both the Hagedorn-Le Mesurier-Steffensen and the Tennison lips were often too long, while the Pfeifer lips were more often too short. Reconstruction of Cupid's bow was somewhat more harmonious following Tennison's method. There was a trend towards fewer disturbing scars with the Pfeifer's procedure. We feel that these findings support our 1970 decision to operate all cleft lips according to the wave-line procedure.

Child↗
PubMed1978

[Surgical technic in the treatment of mandibular osteomyelitis].

Our experience with operative treatment of 70 patients with osteomyelitis of the mandible showed that the incision and drainage of soft-tissue abcesses combined with antibiotic therapy led to healing in 22 patients. More extensive measures, such as sequestectomy, decortication, resection of whole areas of the mandible, and transplantation of autologous cancellous bone, however were necessary with 48 of the patients. A detailed description of the various operative techniques was presented; the respective indications were mentioned.

Abscess↗
PubMed1976

[Intraarterial bleomycin therapy on squamous cell carcinomas of the oral cavity. Clinico-pathological investigations (author's transl)].

The mode of action of bleomycin after intraarterial perfusion in 53 patients with advanced squamous cell carcinoma of the oral cavity is reported on the basis of clinical results and pathologico-anatomic findings. In 29 out of 32 cases not previously treated a clinically complete remission could be achieved by primary chemotherapy. In 8 cases these findings were histomorphologically confirmed and 7 patients have shown a persistant remission for 9 to 61 months. The chances of success are much less favorable in the treatment of recurrences. No clinical advantages were observed when combining bleomycin with other chemotherapeutics.

Antineoplastic Agents↗
PubMed1976

[Central giant cell granuloma. Histochemical and ultrastructural study on giant cell function (author's transl)].

Multinucleated giant cells in giant cell granuloma are formed by cell fusion of capillary pericytes. In our present study we tried to analyze cell function and activity by histologic, histochemical, and electronmicroscopic examination of giant cells. Lysosomal enzymes such as acid phosphatase and amino-peptidase were found in giant cells which is in agreement with former work. By their lysosomal system giant cells are proved phagocytic. In addition, giant cells being localized at trabecular surfaces of newly formed woven bone may develop osteoclastic functions. The enzymatic and funcational resemblance of giant cells and multinucleated osteoclasts points to the possibility of a similar cytogenesis of both cell types.

Bone Resorption↗
PubMed1976

[Central giant cell granuloma: histochemical and ultrastructural study on its histogenesis (author's transl)].

Until now numerous studies on central giant cell granuloma of jawbones have not been able to reveal the histogenesis of this tumourlike lesion. The aim of the present investigation in two surgically proven cases was to study this question by means of histochemical and electron-microscopic methods. Rather similar histochemical properties were shown in giant cells and pericytes of capillary sproute penetrating the granuloma. Cell fusion occurred between both cell types as was observed by electron microscopy. The process of cell fusion is defined by characteristic interdigitations of cell membranes. Therefore pericytes are believed to be the stem cells of multinucleated giant cells in giant cell granuloma. The abundance of giant cells usually occurring in the granuloma might be explained by plenty of capillary sprouts made up by clusters of pericytes. The factors inducing the pericytic cell fusion process are still unknown. The question arises whether cytogenesis of giant cells in giant cell granuloma might be similar in other giant cell lesions or even in the development of multinucleated osteoclasts.

Adult↗