The Canadian drug regulatory process.
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Biomedical subjects
Publications and source records attributed to R Mailhot.
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In a double-blind, parallel trial which lasted 1 week and comprised eighty-eight patients, a study of the response to topical therapy of the infected component of four common eczematous processes showed that the treatment outcome with corticosteroid antimicrobial creams was not influenced by the type of dermatitis. The cream with fluocinonide 0.05% was significantly better than the cream with triamcinolone 0.1%. Both creams were clinically superior to a cream containing only the antimicrobial agents but exerted a similar antimicrobial activity.
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1. Doses of cocaine which cause specific or unspecific supersensitivity in cat spleen did not alter the blocking effect of phenoxybenzamine on the responses of isolated cat spleen strips to noradrenaline.2. The same doses of cocaine did not increase the protection of alpha-adrenoceptors given by noradrenaline during a standard exposure to phenoxybenzamine.3. It is concluded that cocaine does not change the affinity of the alpha-adrenoceptor for noradrenaline, and therefore changes in affinity are not responsible for the potentiating action of cocaine.
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