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Biomedical subjects

R Malik

Publications and source records attributed to R Malik.

At least 19 recordsLinked to original sources
PubMed1992

Total venous inflow occlusion in the normothermic dog: a study of haemodynamic, metabolic and neurological consequences.

The acute haemodynamic and metabolic repercussions of total venous inflow occlusion were evaluated in six normal dogs, each of which underwent two four minute occlusions and one eight minute occlusion at normothermia. A further three dogs underwent a single eight minute period of occlusion and were allowed to recover from anaesthesia. Total venous inflow occlusion was well tolerated by all animals. They remained in sinus rhythm at the completion of occlusion, and unassisted haemodynamic recovery occurred rapidly. Recovery was quicker after four minutes than after eight minutes. There was no clinically detectable neurological impairment in three dogs which were allowed to recover.

Animals↗
PubMed1992

A new technique for surgery of the caudal vena cava in dogs using partial venous inflow occlusion.

The haemodynamic and metabolic effects of caudal vena cava occlusion were evaluated in six normal anaesthetised dogs. Each animal underwent a single eight minute episode of caudal vena cava occlusion. The procedure was well tolerated by all the dogs. Systolic arterial pressure was reduced by 62 +/- 5 per cent and the heart rate increased by 11 +/- 3 per cent. There was rapid haemodynamic recovery after the release of occlusion, all cardiovascular parameters returning to normal spontaneously within five minutes. Caudal vena cava occlusion is therefore safe for periods of up to eight minutes in normal dogs. This technique allows repair of caudal vena caval lesions without necessitating systemic heparinisation and the use of cavoatrial conduits.

Animals↗
PubMed1992

Epidermoid cyst in association with subcutaneous meningioma.

A 17-year-old female presented with a non-tender, firm and fixed swelling in the right frontal region. Skull x-rays revealed soft tissue shadow and mild hyperostosis of the underlying frontal bone. Histopathological examination after excision showed it to be a meningioma with an epidermoid cyst.

Adolescent↗
PubMed1992

Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole.

Twenty-nine cats with naturally occurring cryptococcosis were evaluated prior to commencing oral fluconazole therapy (25-100 mg every 12 h). Affected cats ranged from 2 to 15 years-of-age. Male cats (19; 66%) and Siamese cats (5; 21%) appeared to be over-represented in comparison to the hospital's cat population. Mycotic rhinitis was observed in 24 (83%) of the cases, although nasal cavity involvement was subtle in four animals. Disease of the skin and subcutaneous tissues was present in 15 cases (52%) and amongst these the nasal plane (seven cats) and bridge of the nose (seven cats) were most commonly involved. Primary infection of the central nervous system was not encountered, although one cat developed meningoencephalitis and optic neuritis as a sequel to longstanding nasal cavity disease. Antibodies against the feline immunodeficiency virus (FIV) were detected in eight cats (28%), and these cats tended to have advanced and/or disseminated disease. There was a tendency for cats to develop cryptococcosis during the Australian summer. Organisms were cultured from 27 cases. Cryptococcus neoformans var. neoformans was isolated from 21 cats, while C. neoformans var. gattii was identified in the remaining six. The response to oral fluconazole was excellent in this series, which included many cats with advanced, longstanding or disseminated disease. The fungal infection resolved in all but one advanced case which died after only 4 days of therapy. A dose of 50 mg per cat, given every 12 h, produced a consistently good response without side effects. Lower doses were effective in some cases, while 100 mg every 12 h was required to control the infection in one cat. Serum fluconazole levels obtained during chronic dosing (50 +/- 18 mg l-1, mean +/- SD; 50 mg per cat every 12 h) were highly variable (range 15-80 mg l-1). Concurrent FIV infection did not impart an unfavourable prognosis, although affected cats often required prolonged courses of therapy.

Animals↗
PubMed1991

Structure and expression of the beta-platelet-derived growth factor receptor gene in human tumor cell lines.

Southern digests of DNA from 15 human connective tissue tumor-derived cell lines (and cell strains) and from peripheral blood lymphocytes from normal volunteers were prepared to compare structure of the beta-platelet-derived growth factor receptor gene in normal and tumor-derived cells. The tumor-derived samples had no alterations in gene structure, nor was gene amplification evident. Two restriction fragment length polymorphisms were detected within the beta-receptor gene. Expression of the alpha- and beta-platelet-derived growth factor receptor was quantified using Northern blots. Expression was not tumor-type specific. For example, one rhabdomyosarcoma cell line expressed only the alpha-receptor, whereas two others expressed the beta. In contrast, a human fibroblast cell strain expressed both receptor types. Alterations in receptor expression may be a result of the tumorigenic process.

Alleles↗
PubMed1991

Suspected cranial migration of two sewing needles from the stomach of a dog.

Thoracic radiographs demonstrated a needle-like foreign body within the myocardium of a three-year-old male labrador retriever examined for an unrelated illness. Six months later the dog became lethargic and inappetent. The original foreign body had not moved, and a second needle was present in the stomach. Laparotomy and gastrotomy revealed a sewing needle which had perforated the lesser curvature of the stomach and was migrating cranially. An organised fibrous band extended through the diaphragm, and it is suspected that the original myocardial foreign body had migrated from the stomach by this route.

Animals↗
PubMed1991

Tick paralysis in North America and Australia.

The pathophysiology and clinical manifestations of tick paralysis in North America and Australia are reviewed. Clinical and electrodiagnostic findings in tick paralysis are contrasted with those that occur in other diffuse lower motor neuron disorders, and the disease in North America is compared with the more severe form of the disease that occurs along the east coast of Australia. A detailed account of the treatment of animals afflicted with tick paralysis is presented.

Animals↗
PubMed1991

An unusual case of plasma cell granuloma involving lung and brain.

A young male aged 20 years had resection of the upper lobe of right lung for plasma cell granuloma. Five years later he developed three lesions in the brain, one of which was resected. Brain lesion showed similar histopathological picture. A unique case of plasma cell granuloma involving more than one organ is reported.

Adult↗
PubMed1990

Congenital obstruction of the caudal vena cava in a dog.

A 16-week-old female Rottweiler was examined because of labored breathing and abdominal distention. Ascites, hepatomegaly, and pleural effusion were detected during physical and radiographic examinations. Selective angiography revealed a stenotic lesion at the junction of the caudal vena cava and the right atrium. A fibrous diaphragm with a pin-hole orifice was observed at surgery. Clinical signs of disease resolved after successful removal of the membranous obstruction.

Animals↗