PubMed Health⌕ Search

Biomedical subjects

R Manchanda

Publications and source records attributed to R Manchanda.

77 records · Page 5Linked to original sources
PubMedDate not supplied

15O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients.

Positron emission tomography with oxygen-15 was used to compare regional cerebral blood flow and the regional cerebral metabolic rate of oxygen in a group of predominantly never-treated, acute schizophrenic patients and in matched controls. The results of this study did not support the hypothesis that schizophrenics have reduced frontal blood flow and/or metabolism; and only equivocal support was obtained for the hypothesis that metabolism within the basal ganglia is reduced in schizophrenics. However, support was obtained for the hypothesis that an abnormality in hemisphere laterality may underlie schizophrenic illness.

Acute Disease↗
PubMedDate not supplied

Influence of postdatism and meconium on fetal erythropoietin.

OBJECTIVE: To determine whether fetal erythropoietin (Epo) concentrations are increased in pregnancies extending beyond 41 weeks' gestation and whether this is influenced by the presence of meconium-stained amniotic fluid. METHODS: Epo concentrations were measured in 116 fetal umbilical cord blood samples from otherwise uncomplicated pregnancies between 37 to 43 weeks' gestation during the period of October 1996 to October 1997. An enzyme-linked immunosorbent assay kit was used to measure Epo. Maternal demographics and birth outcomes including Apgar score, cord blood pH, and base deficit were obtained. Fetuses born between 41 and 43 weeks' gestation (post-term) were compared with matched controls born between 37 and 40 weeks' gestation (term). In addition, both post-term and term fetuses with meconium-stained amniotic fluid were compared with matched controls without meconium. RESULTS: Post-term fetuses without meconium had significantly higher Epo levels compared with term fetuses (mean +/- SEM: 50.6 +/- 6.5 versus 29.5 +/- 3.3 mIU/ml, p = 0.002). When matched for gestational age, fetuses with meconium-stained amniotic fluid had significantly greater Epo concentrations compared with controls without meconium (post-term, 80.7 versus 50.6 mIU/ml; term, 61.4 versus 29.5 mIU/ml; p < 0.05). However, no significant difference in Epo levels was found between post-term fetuses with meconium and term fetuses with meconium (80.7 +/- 15.7 mIU/ml versus 61.4 +/- 12.8 mIU/ml, respectively). Mean cord blood pH and base deficit values for all groups were within normal clinical range. CONCLUSION: Cord blood Epo concentrations were significantly increased in pregnancies extending beyond 41 weeks. Irrespective of gestational age, meconium-stained amniotic fluid was associated with a significant rise in Epo. High Epo levels in these pregnancies imply subacute or chronic fetal hypoxia. Close clinical monitoring of post-term fetuses and those with meconium-stained amniotic fluid is warranted.

Adult↗
PubMedDate not supplied

Giant malignant ovarian tumor: a case report.

Massive ovarian tumors are rare and occur less frequently today. The management of a patient with a large ovarian tumor weighing 74 kg is described. Preoperative paracentesis was resorted to. A multidisciplinary team approach helped combat the various associated complications of supine hypotension, technically difficult surgery, massive blood and fluid replacement, postoperative ventilatory failure, and wound dehiscence.

Adenocarcinoma↗