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Biomedical subjects

R Manni

Publications and source records attributed to R Manni.

81 records · Page 5Linked to original sources

[Vascular cysts of the adrenals. Association with aneurysm of the abdominal aorta].

A rare case of an adrenal vascular cyst associated to an abdominal aorta aneurysm is reported. Adrenal cysts are an uncommon clinical finding, in most cases incidentally discovered for nonspecific abdominal pain, during US, TC or RM evaluation or at autopsy. Small adrenal mass are clinically silent. They may be symptomatic (lumbar tension, pain) for dimensions over 10 centimetres. Cysts of large size can cause displacement and compression of adjacent organs. They present a difficult problem of differentiation between benign and malignant lesions. Non-neoplastic adrenal cysts have been divided into four categories: parasitic (7%), epithelial (9%), endothelial (45%) and haemorrhagic or pseudocystic (39%). Vascular adrenal cysts may be a traumatic consequence of an hamartomatous vascular anomaly. The aim of this paper is to discuss, on the basis of the literature, the etiology, diagnosis and treatment of the adrenal mass. Surgical timing is discussed for the concomitant vascular lesion. The elective treatment was left adrenalectomy performed through transperitoneal approach. Surgery for abdominal aorta aneurysm was differed because the adrenal mass was suspected to be an infected neoplastic lesion and for the feasibility of endovascular procedure. The adrenal specimens contained a cystic structure with fluid blood, fibrin and calcifications. Normal adrenal cortical tissue was found in the cystic wall. This lesion (arising from vascular anomalies) require separation from haemorrhagic adrenal neoplasm. Awareness of adrenal pseudocysts and careful attention to the hystological features aids this distinction.

Adrenal Gland Diseases↗

[The non-recurrent inferior laryngeal nerve. Surgical experience].

During the performance of 1018 thyroid operations, 1497 recurrent laryngeal nerves were identified and exposed. Of the 773 visualized nerves on the right side, 2 were found to be non recurrent (0.26%). This abnormality may represent a pitfall during thyroidectomy even for very experienced thyroid surgeons. We emphasize that the exposure and preservation of this vital structure is the standard of care and an essential component of routine dissection in thyroid surgery.

Humans↗

Temporomandibular disorders and sleep disorders: which relationship?

AIM: The aim of this case-control study was to establish statistically significant associations between temporomandibular disorders (TMD) and obstructive sleep apnea (OSA) or excessive daytime sleepiness (EDS) using, respectively, the Douglass Sleep Disorders Questionnaire and the Epworth Sleepiness Scale. METHODS: A total of 100 patients affected by TMD and 100 age- and sex-matched controls randomly chosen from the general population, answered the 2 questionnaires, which investigated their sleep habits, sleep hygiene and sleep disorders. OSA was considered as present if the total Douglass questionnaire score reached or exceeded the cut-off point of 32 for women and 36 for men. The total score on the Epworth Sleepiness Scale was calculated for each subject, a total >10 considered to indicate the presence of EDS. The data were analysed by using the chi squared test. RESULTS: EDS was found in 19% of the patients and in 10% of the control subjects, and OSA in 6 patients and in 4 control subjects. No statistically significant association emerged between TMD and OSA. EDS was more frequent in patients with myofascial pain. On the basis of the results of the first questionnaire, we were able to develop a profile of OSA patients: they are predominantly smokers, middle-aged (40-60 years old), overweight men. CONCLUSIONS: Although most TMD patients complain of poor sleep quality, the age and sex prevalence of OSA was lower than that of TMD, and EDS was found to be present in only a few cases.

Adult↗

[Correlations between EEG and CT in 79 cases of dementia].

An EEG and CT study was carried out on 79 patients affected by dementia (24 SDAT and 55 MID). The EEG and CT patterns were compared with those of an age-matched control group. Statistical analysis of the CT findings between the demented and normal subjects showed significant differences only for severe atrophy. As far as EEG findings are concerned, no EEG pattern indicative of a specific type of dementia was observed even though a greater number of abnormal EEGs occurred in demented patients than in the control group. Finally, a poor EEG-CT correlation was found in demented patients.

Aged↗

[EEG-CT correlates in a group of patients with acute and focal cerebral vascular disorders].

A retrospective study was performed on 120 patients with cerebrovascular accidents in order to correlate EEG, CT and clinical data. A high degree of correlation was found between EEG and CT findings and between these laboratory tests and clinical picture in those subjects with ischemia in the carotid territory. Furthermore the combined use of EEG and CT testing improves the diagnostic validity of both methods.

Adult↗

Epileptic seizures and alcoholism. Clinical and pathogenetic aspects.

The term "alcoholic epilepsy" has had controversial interpretations and has been applied to different alcohol syndromes. In the present study, a homogeneous population of alcohol abusers was retrospectively studied with the aim of clarifying the relationship between alcohol and epilepsy. If subjects who present with potentially epileptogenic lesions are excluded, strictly alcohol-related seizures seem to be withdrawal symptoms from a pathogenetic point of view. They, even if repeated, do not deserve the term "epilepsy" and probably should not be chronically treated with antiepileptic drugs. Finally, no characteristic interictal EEG pattern was found in alcoholics with seizures.

Adult↗

Epileptic seizure during aspirin and caffeine withdrawal in a drug induced headache.

A 45-year-old female migraineur with a long-standing history of drug-induced headache is described. She had been abusing caffeine (250 mg/day) and aspirin (5 gr/day). On the third day after discontinuation a withdrawal syndrome characterized by headache and a generalized tonic-clonic seizure occurred. The temporal association makes it likely that the convulsion episode in an integral component of the withdrawal syndrome in this patient. This extra feature of the withdrawal syndrome has never been described after caffeine and/or aspirin interruption. Possible pathogenetic mechanisms are discussed.

Anti-Inflammatory Agents, Non-Steroidal↗

Nocturnal partial seizures and arousals/awakenings from sleep: an ambulatory EEG study.

The architecture of nocturnal sleep in twenty subjects (9 males, 11 females, mean age 27 years) affected by partial cryptogenic epilepsy was investigated by means of ambulatory EEG (A-EEG) recording performed at home. The study aimed in particular to ascertain the immediate effects of nocturnal partial epileptic seizures on sleep stability and continuity. Data for a total of 49 recorded seizures indicate that 72% of the partial seizures which occurred during sleep were followed by arousal and awakening, and that sleep interruption lasted significantly longer when the seizure occurred between 4 and 7 a.m.

Adolescent↗

Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy.

Serum levels of sex-hormones, sex-hormone binding globulin, gonadotropin, and prolactin were evaluated during the follicular and the luteal phases in 65 women with epilepsy and in 20 healthy controls. Twenty-one patients were treated with sodium valproate (VPA), 21 with phenobarbital (PB), and 23 with carbamazepine (CBZ). VPA does not stimulate liver microsome enzymes, whereas PB and CBZ do. Patients on VPA therapy showed higher body weight and body mass index, but no significant differences in hirsutism score, or in ovary volume or polycystic ovary prevalence (at ultrasound examination). Estradiol levels were lower in all patient groups than in healthy controls in the follicular but not in the luteal phases. VPA affected luteal progesterone surge in 63.6% of cases. This effect was significantly lower in the CBZ and PB groups. Furthermore, increases in testosterone and delta 4-androstenedione levels and in free androgen index, along with a higher luteinizing hormone-follicle-stimulating hormone ratio in the luteal phase, were observed in women treated with VPA. Although sex-hormone binding globulin levels were higher in CBZ and PB than in VPA-treated patients, the differences were not significant because of the wide dispersion of the carrier protein levels. Inducer antiepileptic drugs decreased dehydroepiandrosterone sulfate levels, which remained unchanged during VPA treatment. No significant differences occurred in basal gonadotropin and prolactin levels.

Adolescent↗