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Biomedical subjects

R Marcolongo

Publications and source records attributed to R Marcolongo.

At least 199 records · Page 11Linked to original sources
PubMed1975

An improved method for the determination of 5-phosphoribosyl 1-pyrophosphate.

A spectrophotometric method for the determination of 5-phosphoribosyl 1-pyrophosphate (PRPP) is presented which shows several advantages in comparison to the radiochemical techniques, such as a relatively simple, rapid and less expensive procedure. This technique has been used to evaluate PRPP content in erythrocytes, leukocytes and lymphocytes of normal subjects and individuals with partial hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.8) deficiency. The results obtained proved to be completely reliable in both groups of subjects examined, with values of PRPP similar to those observed by radiochemical techniques.

Adult↗
PubMed1975

Evidence for purine biosynthesis in human leukocytes.

Human leukocytes and lymphocytes have shown to be equipped with 5-phosphoribosyl-1-pyrophosphate amidotransrease, the enzyme which catalyzes the synthesis of the first intermediate of the purine pathway, thus providing evidence that these cells have the capacity for de novo purine biosynthesis.

Amidophosphoribosyltransferase↗
PubMed1975

Hl-A antigens associated with rheumatoid arthritis and ankylosing spondylitis in an ethnic homogeneous population.

The HL-A phenotypes of 52 patients with rhematoid arthritis and 26 patients with ankylosing spondylitis from an ethnic homogeneous population have been determined. No definite association has been established with rheumatoid arthritis, while a very significant association has been found between ankylosing spondylitis and HL-A 27 antigen. This finding suggests that certain patients with ankylosing spondylitis have a genetically determined susceptibility to their disease which could be due to a cross-tolerance mechanism enabling infectious agent antigens to mimic certain histo-compatibility antigens, or to a linkage between HL-A genes and those controlling immune responsiveness.

Arthritis, Rheumatoid↗
PubMed1975

Incidence of hepatitis associated antigen HAA and homologous antibody in patients with rheumatoid arthritis.

The authors have studied the incidence of hepatitis associated antigen (HAA) and the homologous antibody in sera of patients with rheumatoid arthritis on the basis of (1) arthritis sometimes associated with viral hepatitis, (2) the possible infectious etiology of rheumatoid arthritis, and (3) observation on the possible pathogenetic role of HAA in some cases of polyarteritis nodosa. The presence of HAA and antibody titer gave constantly negative results in all subjects examined with the exception of one case which showed no signs of serological or histological hepatic involvement. On the basis of the results obtained, the negligible role of HAA in the etiopathogenesis of rheumatoid arthritis is underlined. However, the authors emphasize as suggestive the hypothesis that the characteristic histopathological alterations of rheumatoid arthritis may be mediated by an immunological reaction toward an infectious agent other than HAA, but operating through mechanisms similar to those of HAA in polyarteritis nodosa.

Antibodies↗
PubMed1975

Serum IgD and IgE in rheumatoid arthritis.

Serum immunoglobulins IgD and IgE have been determined by a single radial immunodiffusion technique and a radioimmunoassay method in serum samples from 95 rheumatoid patients, 5 subjects with Sjögren's syndrome and 50 healthy controls, and compared with levels of IgG, IgM and IgA fractions measured in the same subjects. The IgD and IgE serum content resulted similar in the rheumatoid, Sjögren's and control sera. No correlation of IgD and IgE values with changes of other immunoglobulins or with the activity and the duration of the rheumatoid disease was observed.

Arthritis, Rheumatoid↗