Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-microm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal tissue (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.

Animals↗

PubMedDate not supplied

A retrospective look at long-term adolescent recovery: clinicians talk to researchers.

The purpose of the present article is to identify factors associated with long-term recovery for adolescents. A group of 14 young adults were given semistructured in-depth (one to two hour) interviews. The subjects had been in recovery for two to 16 years. Length of stay in treatment, involvement with self-help groups, psychotropic medication, family support, peer support, spirituality, and other factors were identified as helpful for long-term recovery. A major limitation of this inquiry is that it does not meet minimum standards for research. It is hoped, however, that this inquiry can inform directions for further research.

Adolescent↗