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Biomedical subjects

R Markus

Publications and source records attributed to R Markus.

43 records · Page 3Linked to original sources
PubMed1981

[Risk of hepatitis B in endoscopy personnel].

By anamnestic inquiry and investigation for HBsAg and anti-HBs (RIA) of 120 staff members from 18 endoscopic centers, we found reference to remarkable spread of hepatitis B. Its incidence in endoscopic staff is unambiguously higher than in personal of internal wards. So, 8.3 per cent of endoscopic workers were positive for HBsAg, and anti-HBs was found in 29.7 per cent of them. This study accentuates the high danger by gastro-enterologic patients, who not rarely are HBsAg-positive and infectious. Preventive measures are recommended.

Endoscopy↗
PubMedDate not supplied

Muramyl dipeptide does not induce slow-wave sleep or fever in rats.

The synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), is reported to increase slow-wave sleep and body temperature in cats, rabbits, and squirrel monkeys. The present study examined the ability of MDP to induce sleep and fever in rats. MDP was administered IP at 50, 250 and 500 micrograms/kg. Sleep and body temperature were monitored for 12 hr. MDP failed to affect the duration of wakefulness, S1, S2, or total (S1 + S2) slow-wave sleep. There was also no change in the latency to the first episode of S2 sleep. In contrast, rapid-eye-movement (REM) sleep was significantly suppressed for the first 6 hr after 250 and 500 microgram/kg doses of MDP. There was, however, a rebound increase in REM sleep after the initial period of suppression which resulted in no overall change in the amount of REM sleep. Body temperature was unaffected by MDP. Thus, we conclude that MDP has neither sleep-promoting nor pyrogenic actions in the rat when administered systemically at doses reported to be effective in several other species.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMedDate not supplied

Effects of food on cortisol and mood in vulnerable subjects under controllable and uncontrollable stress.

The aim of this study was to investigate whether in stress-prone subjects, carbohydrate-rich, protein-poor food (CR/PP) diminished depressive mood and a cortisol response under controllable as well as uncontrollable laboratory stress. Twenty-two subjects with high stress proneness (HS) and 23 subjects with low stress proneness (LS) participated in a controllable- and uncontrollable-stress experiment during either a CR/PP or protein-rich, carbohydrate-poor (PR/CP) diet. Both controllable and uncontrollable laboratory stress significantly increased pulse rate and skin conductance in HS and LS subjects, whereas uncontrollable stress increased feelings of depression, anger, tension, and fatigue and decreased feelings of vigor. Only in HS subjects, a cortisol response and feelings of depression became lower under the CR/PP diet condition, irrespective of the controllability of the laboratory stressor, suggesting an increased ability to cope with stress. Because the CR/PP diet compared with the PR/CP diet previously has been found to cause a 42% increase in plasma tryptophan/SigmaLNAA, seen as an indirect measure of increases in brain serotonin levels, the present results suggest that an enhanced serotonin function in HS subjects may be involved.

Adult↗
PubMedDate not supplied

Nasal airway volumetric measurement using segmented HRCT images and acoustic rhinometry.

Semiautomatic segmentation methods using High Resolution Computed Tomography (HRCT) or Magnetic Resonance Imaging give accurate and reproducible volumetric measurements in various intracranial diseases. In this prospective study, for the first time in literature, with the help of a new semiautomatic segmentation technique and coronal HRCT, we correlated the volumes and cross-sectional areas of the nasal cavity with those obtained by clinical acoustic rhinometry in 14 patients with chronic sinusitis. The measurements obtained by both techniques showed statistically significant correlations between volumes in the anterior and middle parts, but statistically poor correlations between the volumes in the posterior part of the nasal cavity. Coronal HRCT and our new microcomputer applicable semiautomatic segmentation software proved compatible with daily clinical practice. Based on the promising results of our study, we recommend the use of this technique in the validation studies of acoustic rhinometry and in complicated cases as a complementary examination in the evaluation of nasal cavity.

Acoustics↗