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Biomedical subjects

R Matheny

Publications and source records attributed to R Matheny.

6 recordsLinked to original sources
PubMed1986

The incidence of colon carcinoma complicating ulcerative colitis.

The tendency for development of cancer in patients with ulcerative colitis is well documented. Each physician must take into account the clinical presentation of the patient and the known risk factors and must adapt follow-up and consultation to the patient and family accordingly. Presently, after a 5- to 7-year history of ulcerative colitis, it is reasonable to document mucosal changes with air-contrast barium enema examination and laboratory assessment with carcinoembryonic antigen levels being obtained. If the extent of disease is more limited to the distal colon, then the surveillance should be modified accordingly because the relative risk is reduced. In the future, the addition of histochemical and immunohistologic analysis of mucosal biopsies will result in better criteria for patient selection for surgical intervention. Because of the delay in recognition of a cancerous lesion in patients with ulcerative colitis, a total proctocolectomy is recommended by some after the first decade of disease. Most prefer, however, to continue surveillance of some type. During surveillance, if moderate or severe dysplasia is found, a proctocolectomy should be performed. This mode of surveillance and treatment of patients at risk for developing colonic carcinoma subsequent to ulcerative colitis remains an evolving process. There will be further changes in management following better classification of the neoplastic changes and the discovery of the etiology of the disease process itself.

Colitis, Ulcerative↗
PubMed1986

Feeding and growth characteristics of human milk-fed infants.

Anthropometric measurements, milk intake, and nursing frequency data of 50 exclusively breast-fed infants were analyzed to determine the existence, extent, and nature of relationships among nursing frequency, quantity of milk consumed, and growth characteristics. In comparison with the National Center for Health Statistics growth standards, anthropometric measures for all infants fell within the 10th and 95th standard percentiles for the following growth parameters: Mean lengths ranged from 54 +/- 2.5 cm at 2 weeks to 64 +/- 1.6 cm at 16 weeks; mean weights ranged from 3,735 +/- 526 gm to 6,326 +/- 633 gm; mean head circumferences ranged from 36 +/- 1.2 cm to 41 +/- 1.0 cm. Significant associations were observed for milk intake with weight and length measures. Strength of association, however, was highly variable across age categories, ranging from 0.32 to 0.71 for weight and 0.16 to 0.70 for length. The coefficients indicate that 10% to 50% of the total variance in weight and 3% to 49% of total variance in length could be ascribable to milk intake. Average milk intakes were significantly correlated with infant length and weight at 2, 6, and 12 weeks. Average frequency of nursing was positively associated with infant weight at 12 weeks. Increases in average milk intakes between 2 and 4 weeks were significantly related to increases in length for the same period. Likewise, an increase in average milk intake between 8 and 12 weeks was associated with a corresponding change in mean length.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Weight↗
PubMed1984

The stability and antitumor activity of recycled (intravesical) mitomycin C.

Although intravesical mitomycin C (MMC) is effective in the treatment of superficial bladder cancer, its expense is a major factor limiting its use. These authors have analyzed the antitumor activity and stability of MMC following 2-hour intravesical instillation in consideration of recycling the drug or using a smaller dose over a longer retention time. The first voided urine samples from 11 patients who received 40 mg MMC intravesically were measured for MMC content by high performance liquid chromatography (HPLC). An average of 50% of the parent drug was recovered. MMC from the urine samples inhibited the growth of a transplantable murine transitional cell carcinoma as effectively as stock drug. Moreover, MMC is relatively stable in human urine at body temperature. These findings suggest that recovery and reuse of the intravesically administered drug is possible and if sterility and appropriate concentrations can be established for the initial and subsequent doses, the drug may be able to be recycled.

Animals↗