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Biomedical subjects

R Matoba

Publications and source records attributed to R Matoba.

66 records · Page 4Linked to original sources
PubMed1989

A statistical study of sudden cardiac death for past five years in Osaka medical, investigated at the Osaka Medical Examiner's Office.

From 1982 to 1986, there were 1230 sudden death cases autopsied in Osaka Medical Examiner's Office. Among them, 810 cases were classified cardiac deaths (SCDs) such as coronary heart disease (77%), cardiomyopathy (7%), valvular disease (3%). All SCD cases were dead within 24 hours after the appearance of the fatal symptoms, and most of them (72%) were supposed to be instantaneous death. Many of the fatal symptoms began in bed (31%), at bath (17%), at toilet (8%) or at work (8%). 34% of them were thought to be healthy by themselves or by their family members before their deaths. Hypertension (38%), coronary heart disease (13%) and diabetes mellitus (11%) were their major past histories recorded. Cardiac lesions such as myocardial hypertrophy, fibrosis and atherosclerosis of coronary artery were frequently admitted in SCD. SCD has been vigorously studied for a long time in various fields including legal medicine, and it has also attracted a great deal of public attention recently. To clarify the causes and the mechanisms of SCD, investigations of the actual situation of SCD cases is essential. Therefore, 1230 autopsy cases of SCD in Osaka Medical Examiner's Office for recent five years were statistically investigated.

Age Factors↗
PubMed1988

Paradoxical effects of amiloride analogs on protein phosphorylation and serotonin release induced by agonists in human platelets.

We examined the effects of newly exploited amiloride analogs on protein phosphorylation and serotonin secretion induced by various agonists in human platelets. 3', 4'-dichlorobenzamil (DCB) and to a lesser extent, 2', 4'-dimethylbenzamil (DMB), which in many cells highly specific inhibitors of Na+/Ca2+-pump, inhibited the phosphorylation of 47K- and 20K-dalton proteins and serotonin secretion in human platelets independently of the action on the pump. DCB also induced dephosphorylation of 47K and 20K after the phosphorylation of these proteins by thrombin and released serotonin by itself.

Amiloride↗
PubMed1988

A patient with hypogonadotropic hypogonadism successfully treated by long-term pulsatile administration of luteinizing hormone-releasing hormone.

A male patient with hypogonadotropic hypogonadism has been treated by pulsatile administration lf luteinizing hormone-releasing hormone (LHRH) (20-25 micrograms, every 2 hours, sc) for 4 years 6 months. His plasma testosterone (T) concentration began to increase after 4 weeks of treatment and reached the normal range in week 5. He showed complete secondary sexual development after 1 year of treatment. His sperm count was normalized after 1 year of treatment. He was married after 29 months of therapy, and has a healthy male child. Blood type tests showed his paternity of the child. During the long duration of pulsatile LHRH therapy, his gonadotropin secretion has been stimulated by LHRH and his T level has been maintained with no observable side effects. There are no other reports of patients treated by pulsatile LHRH injection for such a long duration, but finding in this patient indicated that long-term pulsatile LHRH therapy is a useful and safe method for treatment of hypothalamic hypogonadotropic hypogonadism.

Adult↗
PubMed1987

Plus acceptance in hard contact lens wearers.

Hyperopes fitted with contact lenses often exhibit more plus acceptance compared to full spectacle correction beyond that accounted for by vertex distance considerations. The objective of this investigation was to attempt to identify the possible factors involved with this phenomenon. Eight hyperopes, one myope, and one control hyperope between 20 and 30 years of age were fitted with polymethyl methacrylate lenses, and over-refractions performed on different days with and without corneal anesthesia. The result was that every test hyperope accepted more plus without anesthetic than with anesthetic, by an average of 0.725 D, which was significant (p = 0.0000). One possible mechanism appears to be neurosensory feedback between corneal sensation and the level of accommodative tonus of the ciliary body.

Adult↗
PubMed1986

An autopsy case of acute selenium (selenious acid) poisoning and selenium levels in human tissues.

A case of fatal suicidal ingestion of "Super Blue (Gun Blue)" (gun-blueing) is presented. Post-mortem examination of the patient revealed pulmonary edema with pleural effusion and congestion of the kidney. Necrosis of proximal tubules was found in the kidney by histological examination. "Super Blue" contains 4% selenious acid and 2.5% cupric sulfate in HCl. Levels of selenium and copper in tissues of the toxic case and normal individuals were determined. The selenium levels of tissues of the patient were 9-90-fold higher than that of normal subjects, whereas concentrations of copper were about 2-fold compared to that of control levels. The highest levels of selenium in the tissues of the patient were found in the lung, kidney and stomach contents.

Adult↗
PubMedDate not supplied

Effect of sulfhydryl group modification on age-associated alteration of actomyosin ATPase activity in human myocardium.

Cardiac ventricular actomyosin was prepared from autopsy samples from humans ranging in age from one to 83 years, and its Ca2(+)-ATPase and K(+)-EDTA-ATPase activities were determined in the presence or absence of a sulfhydryl reagent, N-ethylmaleimide (NEM). The Ca2(+)-ATPase activity increased in the presence of appropriate concentrations of NEM. The extent of the stimulation of Ca2(+)-ATPase activity by NEM decreased significantly with age. The ratio of K(+)-EDTA-ATPase activity to Ca2(+)-ATPase activity also decreased with age. This suggests that there is an age-related modification of sulfhydryl groups in the myosin molecule.

Adenosine Triphosphatases↗