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R Matsuyama

Publications and source records attributed to R Matsuyama.

29 records · Page 2Linked to original sources
PubMed1975

[Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)].

The results of clinical studies on OE-7 (erythromycin stearate, enteric coated granule) were as follows. (1) Thirty-two cases with respiratory infections were treated OE-7 by the oral route of 300 mg every 6 hours in 5 cases and 400 mg every 8 hours in 27 cases. In 28 of 32 cases (87.5%) OE-7 was effective. Gram-positive cocci, namely pneumococcus, alpha- and beta-streptococcus, staphylococcus etc. are the most important pathogens in acute respiratory infections statistically and the most of them are susceptible to many chemotherapeutic agents, especially to erythromycin and penicillin. This is the case also with our studies. Acute exacerbation of asthmatic patients are frequently complicated with secondary respiratory infections caused by those pathogens and sometimes this condition in turn exacerbate asthmatic states. In our studies OE-7 displayed a good effect to such cases. (2) As the side effect gastrointestinal disturbances were slightly observed in 8 of 32 cases and allergic reactions in none. Hepatic and renal function test examined in 17 cases revealed no change after treatment. (3) The mean serum concentration of OE-7 by the oral route of 300 mg every 6 hours revealed about two times higher levels than by the same route of 400 mg every 8 hours, the peak was both reached after 3 hours after ingestion 1.96 mcg/ml and 0.97 mcg/ml respectively. This experiment was done for 5 healthy persons in the condition of free food ingestion and cross over in one week interval.

Acute Disease↗
PubMedDate not supplied

Immunoblot analysis of antibodies in human strongyloidiasis.

An electrophoretic transfer technique was used to investigate qualitatively the production of antibodies to Strongyloides stercoralis larvae in 56 patients with strongyloidiasis. SDS-PAGE analysis of the larval extract revealed the presence of at least 33-39 polypeptide bands under either reducing or non-reducing condition. In the immunoblot analysis, almost all patients showed positive reactivity to the polypeptide bands. The reactivity, however, revealed significant variation among the patients, ranging in number of bands from only one to more than 18. Among the bands, 4 with molecular sizes of 97, 66, 41 and 26 kDa were frequently recognized by the patients' sera, indicating that these antigenic components may form an available antigen for immunological testing for strongyloidiasis. On the other hand, the reactivities were very faint in cases of overwhelming strongyloidiasis.

Adult↗