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Biomedical subjects

R Maurus

Publications and source records attributed to R Maurus.

At least 37 records · Page 2Linked to original sources
PubMed1978

Clinical trial of peptichemio in solid tumors of childhood.

Peptichemio (PTC) was utilized in various advanced and disseminated tumors in children. With the schedule that was used, toxicity was mild. Immediate side effects included anaphylactoid reactions which required close supervision of the patient during infusion of the drug. PTC proved efficacious in advanced neuroblastoma. In patients with bone metastases, PTC has a prompt analgesic effect which seems to occur independently of any antitumor action.

Adolescent↗
PubMed1975

Thin-layer chromatography for diagnosis of secreting neuroblastoma.

A thin-layer chromatographic technique for separation and identification of urinary phenolic acids is described. The method is simple enough to be used in the clinical laboratory and from it, an easy biochemical diagnosis of secreting neuroblastoma. The technique is also of interest for research in catabolism of catecholamines. Results obtained in 125 patients, including 8 patients with neuroblastoma are reported.

Adolescent↗
PubMed1975

Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and X-rays.

The authors present the case of a child aged 7 years who suffered from relapsing acute lymphocytic leukemia. Treatment consisting mainly of oral and intrathecal methotrexate and x-ray therapy produced remission of the hematologic symptoms. Three years after the onset of the leukemia, mental deterioration gradually appeared. Radiography of the skull revealed diffuse bilateral calcium deposits in both cerebral and cerebellar hemispheres. Four years after the onset of the disease, a hematologic relapse occurred. Behavioral disorders became more severe and the child died after a period of seizures and unconsciousness. The main pathologic data obtained by the study of a brain biopsy and after a complete postmortem examination consisted of calcifications located bilaterally in the cerebral and cerebellar cortex. No signs of leukemia were present. Cerebral calcification is an extremely rare complication in the course of the therapy of lymphocytic leukemia. Its possible causes are discussed.

Administration, Oral↗
PubMed1975

Brain calcification in a case of acute lymphoblastic leukaemia.

Cortical calcifications, ween on X-ray in the brain of achild suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low teperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared and structure of both types of calcification were similar, but the Mn concentration washigher in case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite..

Brain↗