Chlorozotocin, 120 mg/m2 every 4 weeks, was administered to 22 patients with advanced soft tissue sarcoma. All patients had received extensive prior chemotherapy and had measurable progressive disease at the time of entry in the study. No objective responses were observed. The best individual results were in three patients with disease stabilization lasting 2--4 months. Toxic effects included nausea in one half of the patients and sweating episodes in one. One patient developed temporary leukopenia and three had thrombocytopenia that lasted for 3 weeks, 4 weeks, and 4 months. Blood sugar levels were unaffected by the treatment. No renal or hepatic toxicity was recorded.

Adult↗

PubMedDate not supplied

[Regeneration of myelinated nerve fibers in autologous and homologous transplants: light and electron microscopy studies].

Explore the source record for details and available documents.

Animals↗

PubMedDate not supplied

[Treatment of 95 non-seminomatous germinal tumors of the testis].

A retrospective analysis of 95 treated nonseminomatous germinal testicular tumors is made. The primary treatment consisted of orchidectomy with high ligation of the cord. A histological study disclosed 53 embryonal cell carcinomas (56%), 21 chorioepithelionas (22%), 7 teratocarcinomas (7%) and 14 complex composite tumors which were predominantly dysembryomatous (15%). Forty-three patients were classified as stage I, 13 as stage II and 39 as stage III. Retroperitoneal pelvic and peri-aortic lymphadenectomy performed in patients with a testicular dysembryoma classified as stage I, had a survival of 70% 5 years postoperatively versus only 46 when treated solely with radiotherapy. Stage III cases with choriocarcinoma did not survive 3 years. These results are compared with those reported in the literature. The presently applied therapeutic scheme is described.

Adolescent↗

PubMedDate not supplied

[Treatment of malignant dysembryomas of the ovary. Apropos of 14 cases].

Fourteen cases with a malignant dysembroma of the ovary were treated by resection, postoperative radiotherapy and/or chemotherapy. Eight of the 14 patients survived 2 years and 2 out of 7 are still alive 5 years later. The prognosis depends mainly on the initial stage of the disease. Radiotherapy but most of all chemotherapy may improve the survival rate even in the advanced forms of the disease. The proposed therapy is initial extensive surgery followed by chemotherapy in all cases. Also radiotherapy in those cases in which the resection was considered incomplete.

Adolescent↗

PubMedDate not supplied

Studies on the effect of aurintricarboxylic acid (ATA) on cell proliferation of renewable epithelial tissues in the mouse.

The effect of a three-week treatment regimen with 2, 4 or 6 mg aurintricarboxylic acid (ATA) per kg body weight on the cell proliferation of jejunal crypts and dorsal epidermis of the nude mouse was studied using standard autoradiographic methods after in vivo pulse labelling with 3H-thymidine. ATA was slightly toxic to the animals in a dose-dependent manner (p < 0.01), as measured by the decrease of the rate of weight gain of the treated animals. In the small intestine, ATA led to a shrinkage of crypt length by a factor of 10-15% (p < 0.05), mainly by inhibiting cell proliferation in a dose-dependent manner (p < 0.05) and only secondarily and at higher doses by additionally increasing the cell loss. On the contrary, both the 3H-thymidine labelling index and the mitotic index of the basal cell layer of the epidermis are found to be increased under treatment with ATA. Thus, the present findings indicate that ATA may differentially affect the tissue homeostasis of different renewable epithelia in vivo.

Animals↗