Isolation of infectious measles virus in measles encephalitis.
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Acute Disease↗
Biomedical subjects
R Meyermann
Publications and source records attributed to R Meyermann.
Subacute sclerosing panencephalitis. Transmission of the virus to calves and lambs.
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Animals↗
Brain metastasis in renal cell carcinoma: clinical data and neuropathological differential diagnoses.
Beside lung and skeleton, renal cell carcinoma (RCC) can also metastasize to the brain. In order to collect clinical and histopathological data on these tumors, we studied the local distribution of 50 metastases of RCC in different brain regions (frontal, parietal, temporal occipital lobe and brain stem/cerebellum) and found frequencies ranging from 18.4% to 22.4% in each region. This indicates that there is no preferable site of renal cell carcinoma metastases in the brain. In 46 (92%) of the cases the primary tumor or metastases in other organs had already been diagnosed before operation of a brain metastasis. This shows that the latter mostly is a late manifestation at an advanced stage of disease. 44 (88%) of the metastases showed the typical clear cell pattern. In case of unknown primary tumor, these have to be distinguished from other potentially intracranial neoplasms with similar histologic features. These are chordoma, germinoma, paraganglioma, alveolar sarcoma of soft tissue and the epitheloid variant of malignant peripheral nerve sheath tumor.
Brain Neoplasms↗
Heat shock protein expression in human gliomas.
BACKGROUND: Heat shock proteins (HSP) are cytoprotective, antiapoptotic proteins which may predict clinical prognosis in various types of cancer. Here, we asked whether the differential response to radiochemotherapy and different overall prognosis for astrocytic and oligodendroglial tumours can be accounted for by differences in HSP expression. MATERIAL AND METHODS: We examined aB-crystallin, HSP27, HSP70, HSC70 (HSP73) and HSP90 expression in 44 human gliomas (5 anaplastic and 5 low-grade astrocytomas, 5 anaplastic and 5 low-grade oligodendrogliomas and 24 glioblastomas) by immunohistochemistry. RESULTS: HSP were expressed in the tumour parenchyma of all high-grade and most low-grade gliomas, including oligodendrogliomas. Endothelial cells were more often positive for HSC70 and HSP90, but more often negative for HSP27, in glioblastomas than in the other tumours. HSP were also observed in macrophages/microglial cells, but not in a tumour-specific pattern. CONCLUSION: Different patterns of HSP expression seem not to account for the differential response of these tumours to adjuvant cytotoxic therapy.
Astrocytoma↗
Radioimmunodetection of human glioma xenografts by radiolabelled monoclonal antibodies.
Radiolabelled monoclonal antibodies (131I-MUC 8-22, 131I-MUC 2-63) were used for external scintigraphy of human glioma xenografts. To induce transplantation tumors. 5 x 10(6) cells (85HG-66) of an in vitro established human malignant astrocytoma (N66/85) were inoculated s.c. in BALB/c-nu/nu mice. The labelling of the immunoglobulins with 131iodine was carried out according to the iodogen method, the nude mice, bearing xenograft, received 30 m. 131I-labelled intact monoclonal immunoglobulins (200mCi: 7,4MBq) and the imaging was performed on days 4, 8 and 12 after the application. After 4 days, a clear tumor accumulation of iodinated MUC 2-63 antibodies recognizing surface determinants was visible. This enrichment of monoclonal antibodies (MAbs) led to a characteristic tumor presentation on day 8. Obviously, the MUC 2-63 antibodies remain in the tumor tissue for a long time, so that even on day 12 satisfactory tumor imaging is possible. On the other hand, neither with normal mouse IgG nor with MUC 8-22 antibodies - which react with intracellular structures - could a tumor localization be achieved. The result of the studies on the distribution of 131I-MUC 2-63 on day 19 was that the activity in the tumor tissue was about 4.4 times higher than in the blood and even more times higher than in solid organs.
Animals↗
Demonstration of mercury in the human brain and other organs 17 years after metallic mercury exposure.
A male subject became exposed to metallic mercury vapor at work in 1973. He excreted 1,850 mg Hg/l urine initially. Controls of urine mercury excretion after D-penicillamine administration led to the assumption of a total body clearance of mercury latest since 1976. Subsequently he developed an organic psychosyndrome without detectable signs of classical mercurialism. He never returned to work again and died of lung cancer in 1990. In different organs (brain, kidney, and lung) which were sampled at autopsy elevated levels of mercury were documented by atomic absorption analysis. Histological examination of the tissue by the Danscher and Schroder method, which is specific for mercury, showed a highly positive staining in the majority of nerve cells and cells of other organs. Ultrastructurally mercury could be demonstrated by elemental x-ray analysis within lipofuscin deposits. The lipofuscin content was increased in the mercury positive nerve cells as demonstrated by a strong positive autofluorescence.
Cerebellar Cortex↗
Giant cell tumor of the occipital bone in a case of von Recklinghausen neurofibromatosis.
Von Recklinghausen neurofibromatosis (NF1) is the most common hereditary syndrome predisposing to neoplasia. The most common symptomatic manifestation of NF1 is the plexiform neurofibroma. We describe the case of a patient with classical von Recklinghausen neurofibromatosis presenting with a giant cell tumor (GCT) of the occipital bone infiltrating a surrounding plexiform neurofibroma.
Adult↗