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Biomedical subjects

R Miething

Publications and source records attributed to R Miething.

8 recordsLinked to original sources
PubMed1998

[Pulmonary hemosiderosis and gastroesophageal reflux in an infant].

Pulmonary hemosiderosis (PH) has been described in association with a variety of immunological and non-immunological diseases. It is characterised by iron-deficiency anaemia, hemoptysis and diffuse pulmonary infiltrates based on recurrent intraalveolar hemorrhages. We present the case of a child with pulmonary hemosiderosis and a pathological gastroesophageal reflux activity. The child suffered from recurrent anaemic episodes the age of three months (hemoglobin level up to 5.4 g/dl). The symptoms decreased after removal of the gastroesophageal reflux and accompanying steroid therapy. There has been one relapse of pulmonary hemorrhage seven months later (hemoglobin level 6.1 g/dl). Since then the patient has been in good general condition and the steroid was slowly reduced. No more anaemic episodes occurred. We discuss a possible association of pathological gastroesophageal reflux activity in pulmonary hemosiderosis.

Bronchoalveolar Lavage Fluid↗
PubMed1983

[Cefotaxime and desacetylcefotaxime in cerebrospinal fluid of newborn and premature infants].

On the occasion of clinically indicated lumbar of cisternal punctures in 19 newborn and premature babies treated with Cefotaxime 33 CSF-levels of Cefotaxime (CTX) and it's metabolite Desacetyl-Cefotaxime (D-CTX) were measured by means of HPLC. 6 of the 19 infants suffered from meningitis. The highest CTX-levels were found 2 to 4 hours after the last infusion of CTX (50 or 100 mg/kg within 20 min, each 12 hours). Patients with meningitis showed CTX-levels between 20 mg/l and less than 0.5 mg/l (limit of detection), those without meningitis between 11 mg/l and less than 0.5 mg/l. Because of the widely scattered CTX-levels any dependence from CTX-dosage or from degree of meningeal inflammation is not to be shown. With two exceptions D-CTX-levels ranged from 2 to 20 mg/l. Up to 9 1/2 hours after the last CTX-dose no clear decrease of the D-CTX-concentration in CSF may be seen. On the other hand, D-CTX-levels are also widely scattered. Nevertheless D-CTX apparently stays significantly longer in the CSF than CTX does. An influence of meningeal inflammation on the D-CTX-levels can not be observed. In E. coli- and in Klebsiella-spp. The geometrical means of MIC are found to range below 0.5 mg/l for CTX and below 2 mg/l for D-CTX. Therefore CTX might be recommended for treatment of meningitis caused by these germs. This recommendation may be supported by some reports about good clinical results, from our unit and from the literature as well.

Bacterial Infections↗
PubMed1981

[Transient hypothyroidism after amniofetography in preterm and newborn infants (author's transl)].

Excessive iodine application before delivery produces a transient hypothyroidism in preterm and newborn babies. We report about 6 preterm and newborn babies, who developed a transient hypothyroidism after amniofetography with a combined water and fat soluble radiopaque dye. Two preterm babies died with severe cardio-respiratory insufficiency and in five babies' pulmonary function was inadequate at birth. Since we presume a relation between pulmonary function disorder and hypothyroidism in preterm babies especially, and with regard to the hazards for normal brain development, amniofetography should be avoided in pregnancy. Treatment with l-thyroxine was started on the 1 to 12th day of life and discontinued after a period of three to six weeks.

Contrast Media↗
PubMed1981

[Dyssegmental dwarfism--report on two cases (author's transl)].

Report on 2 cases of dyssegmental dwarfism, a rare lethal form of dwarfism. Both male newborns died from asphyxia immediately after delivery. Its features are malformations of the first visceral arch (Pierre-Robin-Syndrome) malformations of all extremities (Camptomicromelia) and severe malformations of the spine (Anisospondyly), with the vertebral changes serving as the main differential diagnostic feature. Among other things, these malformations are due to defective enchondral ossification; and the disease is presumably autosomal recessive.

Abnormalities, Multiple↗
PubMed1980

[Metatropic dysplasia. A rare skeletal anomaly (author's transl)].

Metatropic dwarfism is a rare form of bone dysplasia which is manifest already at birth. One feature is an early manifestation of progressive kyphoscoliosis, causing a reversal of body proportions. The radiological changes permit classification by establishing the presence of anisospondylia, a "halberd shaped" pelvis and epimetaphyseal ossification disorders. Inheritance is probably autosomal-recessive or dominant.

Dwarfism↗