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Biomedical subjects

R Mittleman

Publications and source records attributed to R Mittleman.

13 recordsLinked to original sources
PubMed2001

Inappropriate ICD therapy due to lead-related noise in an active fixation ICD lead.

INTRODUCTION: Despite advances in technology, problems with effective ventricular endocardial sensing continue to arise and to result in inappropriate implantable cardioverter defibrillator (ICD) therapies. METHODS AND RESULTS: The patient is a 79-year-old man with ischemic cardiomyopathy and ventricular tachycardia (VT) who received inappropriate ICD therapies due to lead-related noise detection. Noise was created by the distal helix, which was not fully deployed, intermittently contacting the internal guidepost of the lead (CPI, Guidant, model 0155). After the complete deployment of the helix the problem resolved and the pacing parameters remained stable. CONCLUSION: To our knowledge, this is the first confirmed case report of non-physiologic sensing secondary to the incompletely deployed helix of an active fixation defibrillation lead. A design flaw with this lead led to its redesign to avoid noise over-sensing.

Aged↗
PubMed1992

Monitoring electron spin by running geonium atom as microaccelerator.

Following the classic work of McMillan and of Bohm and Foldy, we have developed a phase equation describing the microsynchrocyclotron acceleration process in geonium. By computer integration of this equation, we are able to confirm that, by making use of the slight relativistic spin dependence of the zero-energy cyclotron frequencies, the acceleration process can be made selective enough to distinguish between spin-up and spin-down states. Quantum effects have been allowed for approximately.

Journal Article↗
PubMed1992

Ventricular lead transection and atrial lead damage in a young softball player shortly after the insertion of a permanent pacemaker.

We report a case in which permanent pacemaker implantation using a conventional subclavian approach on the throwing side of an avid softball player resulted in complete transection of the ventricular lead and severe damage to the atrial lead. The site of the lead fracture suggested that both leads were crushed between the clavicle and the first rib as a result of the frequent and repetitive arm movement. This case illustrates the importance of the selection of the correct approach for permanent pacing lead insertion.

Adult↗
PubMed1991

Geonium "K" experiment using spin dependency of cyclotron frequency supports g data of earlier geonium "S" work.

By substituting the relativistic spin state dependence of the cyclotron frequency for the continuous Stern-Gerlach effect and running the geonium atom as a microsynchrocyclotron accelerator we have detected spin flips of the individual trapped electron. In our initial efforts we have been able to obtain a simple symmetric spin resonance about 4-fold narrower instead of a complex asymmetric one and also to support but not as yet seriously test the result of the earlier geonium "S" work, g/2 = 1. 001 159 652 185 5(40).

Journal Article↗
PubMed1988

Relativistic cyclotron resonance shape in magnetic bottle geonium.

The thermally excited axial oscillation of the electron through the weak magnetic bottle needed for the continuous Stern-Gerlach effect modulates the cyclotron frequency and produces a characteristic approximately 12-kHz-wide vertical rise-exponential decline line shape of the cyclotron resonance. At the same time the relativistic mass shift decreases the frequency by approximately 200 Hz per cyclotron motion quantum level n. Nevertheless, our analysis of the complex line shape shows that it should be possible to produce an abrupt rise in the cyclotron quantum number n from 0 to approximately 20 over a small fraction of 200 Hz, when the 160-GHz microwave drive approaches the n = 0 --> 1 transition, and a jump of 14 levels over a frequency increment of 200 Hz has already been observed in preliminary work. This realizes an earlier proposal to generate a very sharp cyclotron resonance feature by quasithermal excitation with a square noise band and should provide a way to detect spin flips when a weak bottle is used to reduce the broadening of the g - 2 resonance by a factor of 20.

Journal Article↗
PubMed1978

Determination of drugs of abuse in body fluids by radioimmunoassay.

Only recently has radioimmunoassay been used for the detection of drugs of abuse in body fluids. The radioimmunoassay method is rapid, sensitive, specific, and can be performed with a minimum of sample, while conventional assay methods are time-consuming, relatively insensitive, and require a larger sample volume. Performance of individual radioimmunoassays is identical, and requires about one hour to complete. The radioimmunoassays which have been developed for measurement of drugs of abuse in humans are reviewed in this paper. These new techniques are of importance in individual and/or emergency testing, in screening, and in further research into the effect of these drugs on the functions of the human body.

Amphetamines↗